PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22391558-2	2013	The TET2 gene is a bona fide tumor suppressor frequently mutated in leukemia, and TET enzyme activity is inhibited in IDH1/2-mutated tumors by the oncometabolite 2-hydroxyglutarate, an antagonist of alpha-KG, linking 5mC oxidation to cancer development.	tet	4-7	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	118-122	
32150688-2	2020	TET is an alpha-ketoglutarate (alpha-KG)-dependent enzyme, and the production of alpha-KG is catalyzed by isocitrate dehydrogenase (IDH).	tet	0-3	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	106-130	
21939466-5	2011	Specifically, 2-hydroxyglutarate, the oncometabolite produced by mutant IDH1 and IDH2 proteins, has been shown to function as a competitive inhibitor of various alpha-ketoglutarate (alpha-KG)-dependent dioxygenases, including histone demethylases and members of the ten-eleven-translocation (TET) family of 5-methylcytosine (5mC) hydroxylases.	tet	292-295	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	72-76	
32150688-2	2020	TET is an alpha-ketoglutarate (alpha-KG)-dependent enzyme, and the production of alpha-KG is catalyzed by isocitrate dehydrogenase (IDH).	tet	0-3	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	132-135	
31505989-0	2020	Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells.	tet	82-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	51-55	
30325321-9	2018	Correlation analysis revealed a significant positive correlation between TET and IDH gene expression in perilesional and lesional HS skin.	tet	73-76	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	81-84	
27980696-10	2016	CONCLUSIONS: Despite a slight deregulation in CLL cells compared with normal B cells, we identified a significant association between TET/IDH gene expression and prognosis, suggesting that epigenetic changes could potentially be associated with disease progression.	tet	134-137	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	138-141	
25040794-5	2014	The importance of the TET-mediated cytosine demethylation pathway is also underscored by a recurrent mutation of isocitrate dehydrogenase 1 (IDH1) and IDH2 in hematological malignancies, whose mutation inhibits TET function through a novel oncometabolite, 2-hydroxyglutarate.	tet	22-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	113-139	
25132561-5	2014	We also address the crosstalk between TET and two critical enzymes involved in cell metabolism: O-linked beta-N-acetylglucosamine transferase (OGT) and isocitrate dehydrogenase (IDH).	tet	38-41	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	178-181	
25040794-5	2014	The importance of the TET-mediated cytosine demethylation pathway is also underscored by a recurrent mutation of isocitrate dehydrogenase 1 (IDH1) and IDH2 in hematological malignancies, whose mutation inhibits TET function through a novel oncometabolite, 2-hydroxyglutarate.	tet	22-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	141-145	
25040794-5	2014	The importance of the TET-mediated cytosine demethylation pathway is also underscored by a recurrent mutation of isocitrate dehydrogenase 1 (IDH1) and IDH2 in hematological malignancies, whose mutation inhibits TET function through a novel oncometabolite, 2-hydroxyglutarate.	tet	211-214	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	113-139	
25040794-5	2014	The importance of the TET-mediated cytosine demethylation pathway is also underscored by a recurrent mutation of isocitrate dehydrogenase 1 (IDH1) and IDH2 in hematological malignancies, whose mutation inhibits TET function through a novel oncometabolite, 2-hydroxyglutarate.	tet	211-214	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	141-145