PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24836403-13	2014	Only CYP3A4 and CYP3A5 activated otonecine-type PAs, while all 10 CYPs studied showed the ability to activate retronecine-type PAs.	Pyrrolizidine Alkaloids	48-51	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	16-22	
24836403-13	2014	Only CYP3A4 and CYP3A5 activated otonecine-type PAs, while all 10 CYPs studied showed the ability to activate retronecine-type PAs.	Pyrrolizidine Alkaloids	127-130	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	16-22	
34638760-5	2021	If consumed in error and in large emouns, plants with 1,2-unsaturated PAs induce metabolic breaking-off of the double bonds of the unsaturated PAs, generating PA radicals that may trigger severe liver injury through a process involving microsomal P450 (CYP), with preference of its isoforms CYP 2A6, CYP 3A4, and CYP 3A5.	Pyrrolizidine Alkaloids	143-146	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	313-320	
32798647-6	2020	DHP was also detected in CYP3A5- and 3A7-expressing cells after PA exposure, but to a much lesser extent.	Pyrrolizidine Alkaloids	64-66	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	25-31