PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35636643-2 2022 As a continuation of our investigation into the toxicity and safety assessment of pyrrolizidine alkaloid (PA)-containing herbs, we generated a UGT1A4-humanized (hUGT1A4) transgenic mouse model to systematically study the toxicity, metabolism network, and toxicokinetic characteristics of senecionine (a representative toxic PA) and compared with that in the wide-type controls in parallel. Pyrrolizidine Alkaloids 324-326 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 143-149 35636643-2 2022 As a continuation of our investigation into the toxicity and safety assessment of pyrrolizidine alkaloid (PA)-containing herbs, we generated a UGT1A4-humanized (hUGT1A4) transgenic mouse model to systematically study the toxicity, metabolism network, and toxicokinetic characteristics of senecionine (a representative toxic PA) and compared with that in the wide-type controls in parallel. Pyrrolizidine Alkaloids 324-326 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 161-168