PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25562170-0	2014	Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt.	Trimetazidine	0-13	AKT serine/threonine kinase 1	Homo sapiens	134-137	
35259050-0	2022	Trimetazidine mitigates high glucose-induced retinal endothelial dysfunction by inhibiting PI3K/Akt/mTOR pathway-mediated autophagy.	Trimetazidine	0-13	AKT serine/threonine kinase 1	Homo sapiens	96-99	
35259050-8	2022	In addition, TMZ intervention increased the expression of p-PI3K, p-AKT, and p-mTOR but decreased the expression of LC3I, LC3II, and Beclin 1, which were then partially reversed by P13 K inhibitor (LY294002).	Trimetazidine	13-16	AKT serine/threonine kinase 1	Homo sapiens	68-71	
35259050-10	2022	In summary, TMZ inhibited excessive autophagy by activating PI3K/Akt/mTOR pathway, thereby improving retinal endothelial dysfunction induced by HG.	Trimetazidine	12-15	AKT serine/threonine kinase 1	Homo sapiens	65-68	
35217815-12	2022	These results suggest that trimetazidine enhances myocardial angiogenesis through a direct interaction with Akt and promotion of nuclear translocation of HSF1, and that trimetazidine may be used for the treatment of myocardial angiogenic disorders in hypertensive patients.	Trimetazidine	27-40	AKT serine/threonine kinase 1	Homo sapiens	108-111	
35217815-12	2022	These results suggest that trimetazidine enhances myocardial angiogenesis through a direct interaction with Akt and promotion of nuclear translocation of HSF1, and that trimetazidine may be used for the treatment of myocardial angiogenic disorders in hypertensive patients.	Trimetazidine	169-182	AKT serine/threonine kinase 1	Homo sapiens	108-111	
34537816-9	2021	Mechanically, dexamethasone inhibited the phosphorylation of PI3K/AKT/FoxO3a, which could be attenuated by trimetazidine.	Trimetazidine	107-120	AKT serine/threonine kinase 1	Homo sapiens	66-69	
34537816-10	2021	Conversely, co-treatment with a PI3K/AKT inhibitor, picropodophyllin, remarkably increased the expression of NLRP3 and reversed the protective effects of trimetazidine against dexamethasone-induced C2C12 myotube pyroptosis and atrophy.	Trimetazidine	154-167	AKT serine/threonine kinase 1	Homo sapiens	37-40	
25562170-10	2014	RESULTS: TMZ had a significant protective effect against H/SD-induced apoptosis, accompanied by an increase in Bcl-2 and p-Akt.	Trimetazidine	9-12	AKT serine/threonine kinase 1	Homo sapiens	123-126	
25562170-13	2014	CONCLUSION: Trimetazidine protects human UC-MSCs from H/SD-induced apoptosis via the Akt pathway and may therefore be a potentially useful therapeutic adjunct for transplanting MSCs into damaged heart after myocardial infarction.	Trimetazidine	12-25	AKT serine/threonine kinase 1	Homo sapiens	85-88	
23953053-8	2013	In particular, we found that TMZ was able to activate the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin 2 pathway and to reduce the stress-induced transcriptional upregulation of atrogin-1, muscle ring finger protein 1, and myostatin, all of which are key molecules involved in muscle wasting.	Trimetazidine	29-32	AKT serine/threonine kinase 1	Homo sapiens	84-87	
23528356-0	2013	Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways.	Trimetazidine	44-57	AKT serine/threonine kinase 1	Homo sapiens	173-176	
23528356-4	2013	The results showed that pretreatment of EPCs with TMZ (10 microM) protected the proliferation, adhesion, migration, and apoptosis of EPCs against H2O2, accompanied by an increase in superoxide dismutase (SOD) activity, a decrease in malonaldehyde (MDA) content, and increases in eNOS, Akt phosphorylation, and NO production.	Trimetazidine	50-53	AKT serine/threonine kinase 1	Homo sapiens	285-288	
23528356-5	2013	These TMZ-mediated beneficial effects on EPCs could be attenuated by pre-incubation with the Akt inhibitor triciribine.	Trimetazidine	6-9	AKT serine/threonine kinase 1	Homo sapiens	93-96	
23528356-6	2013	In conclusion, the present study demonstrates that TMZ ameliorated H2O2-induced impairment of biological functions in EPCs with the involvement of antioxidation and Akt/eNOS signaling pathway.	Trimetazidine	51-54	AKT serine/threonine kinase 1	Homo sapiens	165-168