PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15307192-5	2004	In contrast, the inflammatory response of recipients of adoptively transferred Tc2 cells (producing high levels of IL-4 but little IFN-gamma) was characterized by significantly increased numbers of eosinophils and induction of BHR to methacholine.	Methacholine Chloride	234-246	interleukin 4	Mus musculus	115-119	
20592486-6	2010	The present study showed that methacholine AHR and lung inflammation developed in allergen-challenged IL-4-deficient mice but not in allergen-challenged IL-13-deficient mice.	Methacholine Chloride	30-42	interleukin 4	Mus musculus	102-106	
18214922-6	2008	RESULTS: DEP induced significant increases in methacholine-induced Penh and IL-4 levels in BAL fluid relative to the control group.	Methacholine Chloride	46-58	interleukin 4	Mus musculus	76-80	
15356571-0	2004	IL-4-independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease.	Methacholine Chloride	37-49	interleukin 4	Mus musculus	0-4	
15356571-3	2004	OBJECTIVE: This study evaluates the effect of IL-4 on the severity of methacholine-induced AHR associated with mycoplasma pulmonary mycoplasma infection.	Methacholine Chloride	70-82	interleukin 4	Mus musculus	46-50	
15356571-7	2004	However, IL-4 KO mice had significantly higher methacholine-induced AHR after M pulmonis infection when compared with BALB/c mice.	Methacholine Chloride	47-59	interleukin 4	Mus musculus	9-13	
15356571-9	2004	CONCLUSION: In contrast to our hypothesis, IL-4-independent pathways exacerbate methacholine-induced AHR and promote airway obstruction during the pathogenesis of mycoplasma respiratory disease.	Methacholine Chloride	80-92	interleukin 4	Mus musculus	43-47	
10830775-6	2000	In contrast, interleukin-4-deficient mice exhibited no decrease in airway inflammation, but had significantly greater epithelial hypertrophy and subepithelial fibrosis, as well as exaggerated hyperreactivity to methacholine.	Methacholine Chloride	211-223	interleukin 4	Mus musculus	13-26	
12789240-9	2003	Moreover, goblet cell metaplasia and airway responsiveness to methacholine could be reduced significantly by the IL-4/IL-13 inhibitor.	Methacholine Chloride	62-74	interleukin 4	Mus musculus	113-117	
8755560-8	1996	Thus, the expression of IL-4 selectively within the lung elicits an inflammatory response characterized by epithelial cell hypertrophy, and the accumulation of macrophages, lymphocytes, eosinophils, and neutrophils without resulting in an alteration in airway reactivity to inhaled methacholine.	Methacholine Chloride	282-294	interleukin 4	Mus musculus	24-28