PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7889288-2	1994	Contractions in human bronchial rings evoked by methacholine (10(-6) M) were reversed by single contractions of alpha-human atrial natriuretic peptide (10(-6) M), salbutamol (10(-6) M), sodium nitroprusside (10(-6) M) or isosorbide dinitrate (4.2 x 10(-5) M) and the extent of the relaxations compared.	Methacholine Chloride	48-60	natriuretic peptide A	Homo sapiens	124-150	
7889288-5	1994	ANP and salbutamol were equipotent in reversing methacholine-evoked contraction and, in combination these agonists evoked an additive response.	Methacholine Chloride	48-60	natriuretic peptide A	Homo sapiens	0-3	
7889288-9	1994	ANP (10(-6) M) and salbutamol (10(-6) M) each attenuated subsequent contractions evoked by methacholine, an ability not shared with sodium nitroprusside (10(-6) M) or isosorbide dinitrate (4.2 x 10(-5) M).	Methacholine Chloride	91-103	natriuretic peptide A	Homo sapiens	0-3	
7889288-12	1994	In combination, ANP and salbutamol attenuated contractions evoked by methacholine to a significantly greater degree than that seen with either agonist alone, whilst a combination of ANP and sodium nitroprusside evoked no greater effect than that seen with ANP alone.	Methacholine Chloride	69-81	natriuretic peptide A	Homo sapiens	16-19	
7889288-13	1994	By contrast, isosorbide dinitrate and ANP together evoked a greater inhibition than ANP alone.5 These results suggest that a combination of agents such as ANP and salbutamol evokes a greater effect than either alone, both in reversing and protecting against methacholine-evoked contractions.Such combinations may be of benefit in the treatment of patients, allowing lower doses of drug to be used.	Methacholine Chloride	258-270	natriuretic peptide A	Homo sapiens	38-41