PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Acetyl Coenzyme A	110-120	acetone-cyanohydrin lyase	Arabidopsis thaliana	0-17	
15608338-0	2005	Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis.	Acetyl Coenzyme A	46-56	acetone-cyanohydrin lyase	Arabidopsis thaliana	71-88	
15608338-6	2005	These data indicate that ACL is required for normal growth and development and that no other source of acetyl-CoA can compensate for ACL-derived acetyl-CoA.	Acetyl Coenzyme A	145-155	acetone-cyanohydrin lyase	Arabidopsis thaliana	133-136	
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	112-122	acetone-cyanohydrin lyase	Arabidopsis thaliana	70-73	
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	112-122	acetone-cyanohydrin lyase	Arabidopsis thaliana	225-228	
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	267-277	acetone-cyanohydrin lyase	Arabidopsis thaliana	70-73	
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	267-277	acetone-cyanohydrin lyase	Arabidopsis thaliana	225-228	
12376641-11	2002	Taken together, these results indicate that ACL, encoded by the ACLA and ACLB genes of Arabidopsis, generates cytosolic acetyl-CoA.	Acetyl Coenzyme A	120-130	acetone-cyanohydrin lyase	Arabidopsis thaliana	44-47	
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Acetyl Coenzyme A	110-120	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22	
11171137-7	2000	Our results indicate that ACL generates the cytosolic pool of acetyl-CoA, which is the substrate required for the biosynthesis of a variety of phytochemicals, including cuticular waxes and flavonoids.	Acetyl Coenzyme A	62-72	acetone-cyanohydrin lyase	Arabidopsis thaliana	26-29	
28532507-4	2017	However, two enzymes acting upstream of HMGR have not been characterized in dandelion latex: ATP citrate lyase (ACL), which provides the acetyl-CoA utilized in the MVA pathway, and acetoacetyl-CoA thiolase (AACT), which catalyzes the first step in the pathway to produce acetoacetyl-CoA.	Acetyl Coenzyme A	137-147	acetone-cyanohydrin lyase	Arabidopsis thaliana	112-115	
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Acetyl Coenzyme A	10-20	acetone-cyanohydrin lyase	Arabidopsis thaliana	138-155	
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Acetyl Coenzyme A	10-20	acetone-cyanohydrin lyase	Arabidopsis thaliana	157-160	
24844815-2	2014	Plants over-expressing ACL were generated in an effort to understand the contribution of ACL activity to the carbon flux of acetyl-CoA to metabolic pathways occurring in the cytosol.	Acetyl Coenzyme A	124-134	acetone-cyanohydrin lyase	Arabidopsis thaliana	23-26	
24844815-2	2014	Plants over-expressing ACL were generated in an effort to understand the contribution of ACL activity to the carbon flux of acetyl-CoA to metabolic pathways occurring in the cytosol.	Acetyl Coenzyme A	124-134	acetone-cyanohydrin lyase	Arabidopsis thaliana	89-92	
24844815-7	2014	Synthesis of PHB and over-expression of ACL also changed the amount of the cutin monomer octadecadien-1,18-dioic acid, revealing an unsuspected link between cytosolic acetyl-CoA and cutin biosynthesis.	Acetyl Coenzyme A	167-177	acetone-cyanohydrin lyase	Arabidopsis thaliana	40-43	
24844815-8	2014	Together, these results reveal the complexity of ACL regulation and its central role in influencing the carbon flux to metabolic pathways using cytosolic acetyl-CoA, including wax and polyisoprenoids.	Acetyl Coenzyme A	154-164	acetone-cyanohydrin lyase	Arabidopsis thaliana	49-52