PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21941478-9 2011 In addition, considerable fluxes through pyruvate carboxylase [PC; PC/pyruvate dehydrogenase (PDH) ratio = 0.5], malic enzyme (5% of the total pyruvate production), and catabolism of branched-chained amino acids (contributing with ~40% to total acetyl-CoA produced) confirmed the significance of these pathways to astrocytic metabolism. Acetyl Coenzyme A 245-255 pyruvate carboxylase Homo sapiens 41-61 21426897-0 2011 Probing the allosteric activation of pyruvate carboxylase using 2",3"-O-(2,4,6-trinitrophenyl) adenosine 5"-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA. Acetyl Coenzyme A 172-182 pyruvate carboxylase Homo sapiens 37-57 21426897-2 2011 MgTNP-ATP was found to be an allosteric activator of pyruvate carboxylase that exhibits competition with acetyl CoA in activating the enzyme. Acetyl Coenzyme A 105-115 pyruvate carboxylase Homo sapiens 53-73 18613815-5 2008 PC from most organisms is a tetrameric protein that is allosterically regulated by acetyl-CoA and aspartate. Acetyl Coenzyme A 83-93 pyruvate carboxylase Homo sapiens 0-2 9597748-3 1998 Diabetes and hyperthyroidism increase the level of expression of pyruvate carboxylase in the long term, while its activity in the short term is controlled by the intramitochondrial concentrations of acetyl-CoA and pyruvate. Acetyl Coenzyme A 199-209 pyruvate carboxylase Homo sapiens 65-85 8620009-0 1996 Effects of acetyl CoA on the pre-steady-state kinetics of the biotin carboxylation reaction of pyruvate carboxylase. Acetyl Coenzyme A 11-21 pyruvate carboxylase Homo sapiens 95-115 8251494-0 1993 Locus of action of acetyl CoA in the biotin-carboxylation reaction of pyruvate carboxylase. Acetyl Coenzyme A 19-29 pyruvate carboxylase Homo sapiens 70-90 1445229-1 1992 Preparations of pyruvate carboxylase catalyse the cleavage of MgATP in the absence of pyruvate and acetyl-CoA. Acetyl Coenzyme A 99-109 pyruvate carboxylase Homo sapiens 16-36 2492793-7 1989 Depletion of acetyl CoA was sufficient to account for greater than 50% reduction in pyruvate carboxylase activity. Acetyl Coenzyme A 13-23 pyruvate carboxylase Homo sapiens 84-104 2492793-8 1989 Competition between acetyl CoA and benzoyl CoA for the activator site on pyruvate carboxylase was insignificant. Acetyl Coenzyme A 20-30 pyruvate carboxylase Homo sapiens 73-93 2492793-9 1989 Results support the interpretation that the observed inhibition of pyruvate carboxylase occurred primarily by depletion of the activator, acetyl CoA, through sequestration of coenzyme A during benzoate metabolism. Acetyl Coenzyme A 138-148 pyruvate carboxylase Homo sapiens 67-87 412860-11 1977 This observation, coupled with the intermittent hypercholesterolemia and the increased tissue acetyl-CoA concentrations, suggests that pyruvate carboxylase is important in modulating the fractional distribution of intracellular acetyl-CoA between the tricarboxylic acid cycle, the beta-hydroxy-beta-methyl-glutaryl-CoA cycle (and the synthesis of cholesterol and ketone bodies), and fatty acid synthesis. Acetyl Coenzyme A 94-104 pyruvate carboxylase Homo sapiens 135-155 412860-11 1977 This observation, coupled with the intermittent hypercholesterolemia and the increased tissue acetyl-CoA concentrations, suggests that pyruvate carboxylase is important in modulating the fractional distribution of intracellular acetyl-CoA between the tricarboxylic acid cycle, the beta-hydroxy-beta-methyl-glutaryl-CoA cycle (and the synthesis of cholesterol and ketone bodies), and fatty acid synthesis. Acetyl Coenzyme A 228-238 pyruvate carboxylase Homo sapiens 135-155 939224-1 1976 Kinetic methods have been used to determine the interrelationship between HCO-3, pyruvate and acetyl-CoA and their effect on pigeon kidney pyruvate carboxylase (pyruvate: CO2 ligase [ADP], EC 6.4.1.1). Acetyl Coenzyme A 94-104 pyruvate carboxylase Homo sapiens 139-159 11947089-0 1973 Apparent co-operative effect of acetyl-CoA on pigeon liver pyruvate carboxylase. Acetyl Coenzyme A 32-42 pyruvate carboxylase Homo sapiens 59-79 11946875-0 1972 Apparent co-operative effect of acetyl-CoA on pigeon kidney pyruvate carboxylase. Acetyl Coenzyme A 32-42 pyruvate carboxylase Homo sapiens 60-80 4354325-4 1972 Pyruvate carboxylase activity was present in all insect flight muscles that were investigated: in homogenates of bumble-bee flight muscle the activity was inhibited by ADP and activated by acetyl-CoA, and it was distributed mainly in the mitochondrial fraction. Acetyl Coenzyme A 189-199 pyruvate carboxylase Homo sapiens 0-20 5938922-0 1966 The participation of acetyl-CoA in pyruvate carboxylase. Acetyl Coenzyme A 21-31 pyruvate carboxylase Homo sapiens 35-55