PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21941478-9	2011	In addition, considerable fluxes through pyruvate carboxylase [PC; PC/pyruvate dehydrogenase (PDH) ratio = 0.5], malic enzyme (5% of the total pyruvate production), and catabolism of branched-chained amino acids (contributing with ~40% to total acetyl-CoA produced) confirmed the significance of these pathways to astrocytic metabolism.	Acetyl Coenzyme A	245-255	pyruvate carboxylase	Homo sapiens	41-61	
21426897-0	2011	Probing the allosteric activation of pyruvate carboxylase using 2",3"-O-(2,4,6-trinitrophenyl) adenosine 5"-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA.	Acetyl Coenzyme A	172-182	pyruvate carboxylase	Homo sapiens	37-57	
21426897-2	2011	MgTNP-ATP was found to be an allosteric activator of pyruvate carboxylase that exhibits competition with acetyl CoA in activating the enzyme.	Acetyl Coenzyme A	105-115	pyruvate carboxylase	Homo sapiens	53-73	
18613815-5	2008	PC from most organisms is a tetrameric protein that is allosterically regulated by acetyl-CoA and aspartate.	Acetyl Coenzyme A	83-93	pyruvate carboxylase	Homo sapiens	0-2	
9597748-3	1998	Diabetes and hyperthyroidism increase the level of expression of pyruvate carboxylase in the long term, while its activity in the short term is controlled by the intramitochondrial concentrations of acetyl-CoA and pyruvate.	Acetyl Coenzyme A	199-209	pyruvate carboxylase	Homo sapiens	65-85	
8620009-0	1996	Effects of acetyl CoA on the pre-steady-state kinetics of the biotin carboxylation reaction of pyruvate carboxylase.	Acetyl Coenzyme A	11-21	pyruvate carboxylase	Homo sapiens	95-115	
8251494-0	1993	Locus of action of acetyl CoA in the biotin-carboxylation reaction of pyruvate carboxylase.	Acetyl Coenzyme A	19-29	pyruvate carboxylase	Homo sapiens	70-90	
1445229-1	1992	Preparations of pyruvate carboxylase catalyse the cleavage of MgATP in the absence of pyruvate and acetyl-CoA.	Acetyl Coenzyme A	99-109	pyruvate carboxylase	Homo sapiens	16-36	
2492793-7	1989	Depletion of acetyl CoA was sufficient to account for greater than 50% reduction in pyruvate carboxylase activity.	Acetyl Coenzyme A	13-23	pyruvate carboxylase	Homo sapiens	84-104	
2492793-8	1989	Competition between acetyl CoA and benzoyl CoA for the activator site on pyruvate carboxylase was insignificant.	Acetyl Coenzyme A	20-30	pyruvate carboxylase	Homo sapiens	73-93	
2492793-9	1989	Results support the interpretation that the observed inhibition of pyruvate carboxylase occurred primarily by depletion of the activator, acetyl CoA, through sequestration of coenzyme A during benzoate metabolism.	Acetyl Coenzyme A	138-148	pyruvate carboxylase	Homo sapiens	67-87	
412860-11	1977	This observation, coupled with the intermittent hypercholesterolemia and the increased tissue acetyl-CoA concentrations, suggests that pyruvate carboxylase is important in modulating the fractional distribution of intracellular acetyl-CoA between the tricarboxylic acid cycle, the beta-hydroxy-beta-methyl-glutaryl-CoA cycle (and the synthesis of cholesterol and ketone bodies), and fatty acid synthesis.	Acetyl Coenzyme A	94-104	pyruvate carboxylase	Homo sapiens	135-155	
412860-11	1977	This observation, coupled with the intermittent hypercholesterolemia and the increased tissue acetyl-CoA concentrations, suggests that pyruvate carboxylase is important in modulating the fractional distribution of intracellular acetyl-CoA between the tricarboxylic acid cycle, the beta-hydroxy-beta-methyl-glutaryl-CoA cycle (and the synthesis of cholesterol and ketone bodies), and fatty acid synthesis.	Acetyl Coenzyme A	228-238	pyruvate carboxylase	Homo sapiens	135-155	
939224-1	1976	Kinetic methods have been used to determine the interrelationship between HCO-3, pyruvate and acetyl-CoA and their effect on pigeon kidney pyruvate carboxylase (pyruvate: CO2 ligase [ADP], EC 6.4.1.1).	Acetyl Coenzyme A	94-104	pyruvate carboxylase	Homo sapiens	139-159	
11947089-0	1973	Apparent co-operative effect of acetyl-CoA on pigeon liver pyruvate carboxylase.	Acetyl Coenzyme A	32-42	pyruvate carboxylase	Homo sapiens	59-79	
11946875-0	1972	Apparent co-operative effect of acetyl-CoA on pigeon kidney pyruvate carboxylase.	Acetyl Coenzyme A	32-42	pyruvate carboxylase	Homo sapiens	60-80	
4354325-4	1972	Pyruvate carboxylase activity was present in all insect flight muscles that were investigated: in homogenates of bumble-bee flight muscle the activity was inhibited by ADP and activated by acetyl-CoA, and it was distributed mainly in the mitochondrial fraction.	Acetyl Coenzyme A	189-199	pyruvate carboxylase	Homo sapiens	0-20	
5938922-0	1966	The participation of acetyl-CoA in pyruvate carboxylase.	Acetyl Coenzyme A	21-31	pyruvate carboxylase	Homo sapiens	35-55