PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26629747-3	2016	Moreover, the inhibitory intensity of GKRP-GK is suppressed by fructose 1-phosphate (F1P), and reinforced by fructose 6-phosphate (F6P).	fructose-6-phosphate	109-129	glucokinase regulator	Homo sapiens	38-42	
27174229-4	2016	Fructose 6-phosphate, a known enhancer of GKRP action, promotes formation of the initial encounter complex via a 2.6-fold increase in kon and stabilizes the complex through a 60-fold decrease in koff.	fructose-6-phosphate	0-20	glucokinase regulator	Homo sapiens	42-46	
28516783-2	2017	Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate promote assembly of the GCK-GKRP complex, whereas fructose 1-phosphate and functionalized piperazines with potent in vivo antidiabetic activity disrupt the complex.	fructose-6-phosphate	20-40	glucokinase regulator	Homo sapiens	94-98	
26629747-3	2016	Moreover, the inhibitory intensity of GKRP-GK is suppressed by fructose 1-phosphate (F1P), and reinforced by fructose 6-phosphate (F6P).	fructose-6-phosphate	131-134	glucokinase regulator	Homo sapiens	38-42	
18556336-1	2008	OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate.	fructose-6-phosphate	245-265	glucokinase regulator	Homo sapiens	188-218	
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase regulator	Homo sapiens	0-30	
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase regulator	Homo sapiens	32-36	
23621087-3	2013	GKRP in turn is activated by fructose 6-phosphate (F6P) and inactivated by fructose 1-phosphate (F1P).	fructose-6-phosphate	29-49	glucokinase regulator	Homo sapiens	0-4	
23621087-3	2013	GKRP in turn is activated by fructose 6-phosphate (F6P) and inactivated by fructose 1-phosphate (F1P).	fructose-6-phosphate	51-54	glucokinase regulator	Homo sapiens	0-4	
23957911-4	2013	Formation of the mammalian GCK-GKRP complex is stimulated by fructose 6-phosphate and antagonized by fructose 1-phosphate.	fructose-6-phosphate	61-81	glucokinase regulator	Homo sapiens	31-35	
23957911-5	2013	Here we report the crystal structure of the mammalian GCK-GKRP complex in the presence of fructose 6-phosphate at a resolution of 3.50 A.	fructose-6-phosphate	90-110	glucokinase regulator	Homo sapiens	58-62	
18809676-4	2008	In the presence of fructose-6-phosphate, GK-GKRP complex formation displayed a strong entropic driving force opposed by a large positive enthalpy; a negative change in heat capacity was observed (Kd = 45 nm, DeltaH = 15.6 kcal/mol, TDeltaS = 25.7 kcal/mol, DeltaCp = -354 cal mol(-1) K(-1)).	fructose-6-phosphate	19-39	glucokinase regulator	Homo sapiens	44-48	
18556336-1	2008	OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate.	fructose-6-phosphate	245-265	glucokinase regulator	Homo sapiens	220-224	
12739015-9	2003	Mutation Arg518Gln, replacing a conserved residue, led to a marked decrease in the affinity of GKRP for both fructose 6-phosphate and fructose 1-phosphate and to a destabilization of GKRP.	fructose-6-phosphate	109-129	glucokinase regulator	Homo sapiens	95-99	
14627435-3	2004	Human GKRP is a more potent inhibitor of glucokinase than rat GKRP in the absence of fructose 6-phosphate or sorbitol 6-phosphate, and has a higher affinity for these ligands.	fructose-6-phosphate	85-105	glucokinase regulator	Homo sapiens	6-10	
9230355-4	1997	Glucokinase regulatory protein gelled F-actin, and gelation was specifically inhibited by glucokinase and the regulatory protein effectors fructose-1-phosphate (F1P) and fructose-6-phosphate (F6P).	fructose-6-phosphate	170-190	glucokinase regulator	Homo sapiens	0-30	
9230355-4	1997	Glucokinase regulatory protein gelled F-actin, and gelation was specifically inhibited by glucokinase and the regulatory protein effectors fructose-1-phosphate (F1P) and fructose-6-phosphate (F6P).	fructose-6-phosphate	192-195	glucokinase regulator	Homo sapiens	0-30