PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18556336-1	2008	OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate.	fructose-6-phosphate	245-265	glucokinase	Homo sapiens	32-35	
28516783-2	2017	Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate promote assembly of the GCK-GKRP complex, whereas fructose 1-phosphate and functionalized piperazines with potent in vivo antidiabetic activity disrupt the complex.	fructose-6-phosphate	20-40	glucokinase	Homo sapiens	90-93	
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase	Homo sapiens	53-64	
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase	Homo sapiens	32-35	
23957911-4	2013	Formation of the mammalian GCK-GKRP complex is stimulated by fructose 6-phosphate and antagonized by fructose 1-phosphate.	fructose-6-phosphate	61-81	glucokinase	Homo sapiens	27-30	
23957911-5	2013	Here we report the crystal structure of the mammalian GCK-GKRP complex in the presence of fructose 6-phosphate at a resolution of 3.50 A.	fructose-6-phosphate	90-110	glucokinase	Homo sapiens	54-57	
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	fructose-6-phosphate	124-144	glucokinase	Homo sapiens	15-26	
11076949-1	2001	Using overexpressed Escherichia coli sorbitol-6-phosphate dehydrogenase to monitor fructose 6-phosphate formation, we found that the stimulation of fructose phosphorylation by glucose was reduced in two human beta-cell glucokinase mutants with a low Hill coefficient or when the activity of wild type glucokinase was decreased by replacing ATP with poorer nucleotide substrates.	fructose-6-phosphate	83-103	glucokinase	Homo sapiens	219-230	
10620331-5	2000	In the presence of 0.2 mM d-fructose 6-phosphate, the glucokinase regulatory protein caused a concentration-related inhibition of d-glucose phosphorylation, such an effect fading out at high concentrations of either d-glucose or glucokinase relative to that of its regulatory protein.	fructose-6-phosphate	26-48	glucokinase	Homo sapiens	54-65	
10620331-5	2000	In the presence of 0.2 mM d-fructose 6-phosphate, the glucokinase regulatory protein caused a concentration-related inhibition of d-glucose phosphorylation, such an effect fading out at high concentrations of either d-glucose or glucokinase relative to that of its regulatory protein.	fructose-6-phosphate	26-48	glucokinase	Homo sapiens	229-240	
10620331-6	2000	The phosphorylation of alpha-d-glucose by liver glucokinase appeared more resistant than that of beta-d-glucose to the inhibitory action of d-fructose 6-phosphate, as mediated by the glucokinase regulatory protein.	fructose-6-phosphate	140-162	glucokinase	Homo sapiens	48-59	
10620331-6	2000	The phosphorylation of alpha-d-glucose by liver glucokinase appeared more resistant than that of beta-d-glucose to the inhibitory action of d-fructose 6-phosphate, as mediated by the glucokinase regulatory protein.	fructose-6-phosphate	140-162	glucokinase	Homo sapiens	183-194	
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	fructose-6-phosphate	124-144	glucokinase	Homo sapiens	28-30	
9230355-4	1997	Glucokinase regulatory protein gelled F-actin, and gelation was specifically inhibited by glucokinase and the regulatory protein effectors fructose-1-phosphate (F1P) and fructose-6-phosphate (F6P).	fructose-6-phosphate	192-195	glucokinase	Homo sapiens	90-101	
8280078-16	1993	Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase.	fructose-6-phosphate	65-85	glucokinase	Homo sapiens	122-133	
7733279-6	1995	The hypothesis that fructose 6-phosphate and a protein regulator modulate glucokinase activity was evaluated by simulation analysis, as was the possibility that glucose-6-phosphatase, working in concert with phosphofructokinase, can modulate the glucose-sensing system.	fructose-6-phosphate	20-40	glucokinase	Homo sapiens	74-85