PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24764253-0	2015	The inhibition of acetylcholinesterase by dantrolene and ondansetron.	Dantrolene	42-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38	
34047061-2	2021	Herein, twenty-one novel dantrolene-like hydrazide and hydrazone analogues were synthesized with the aim of exploring structure-activity relationships (SARs) for the inhibition of human monoamine oxidases (MAOs) and acetylcholinesterase (AChE), two well-established target enzymes for anti-AD drugs.	Dantrolene	25-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	216-236	
31901380-0	2020	Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene.	Dantrolene	71-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-30	
31901380-2	2020	Recently, it has been reported that dantrolene has a weak inhibitory effect on acetylcholinesterase (AChE), which is a therapeutic drug target for Alzheimer"s disease.	Dantrolene	36-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99	
31901380-2	2020	Recently, it has been reported that dantrolene has a weak inhibitory effect on acetylcholinesterase (AChE), which is a therapeutic drug target for Alzheimer"s disease.	Dantrolene	36-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105	
31901380-3	2020	Thus, we focused on developing of AChE inhibitors with benzylpiperidine/piperazine moieties that are based on the dantrolene skeleton.	Dantrolene	114-124	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38	
34047061-2	2021	Herein, twenty-one novel dantrolene-like hydrazide and hydrazone analogues were synthesized with the aim of exploring structure-activity relationships (SARs) for the inhibition of human monoamine oxidases (MAOs) and acetylcholinesterase (AChE), two well-established target enzymes for anti-AD drugs.	Dantrolene	25-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	238-242	
24764253-1	2015	PURPOSE: A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE).	Dantrolene	84-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	170-190	
24764253-1	2015	PURPOSE: A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE).	Dantrolene	84-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196	
24764253-3	2015	METHODS AND FINDINGS: Using AChE from human erythrocytes as enzyme source, it is shown that dantrolene and ondansetron inhibit AChE with IC(50) values of 12.8 microM and 37.1 microM, respectively.	Dantrolene	92-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32	
24764253-3	2015	METHODS AND FINDINGS: Using AChE from human erythrocytes as enzyme source, it is shown that dantrolene and ondansetron inhibit AChE with IC(50) values of 12.8 microM and 37.1 microM, respectively.	Dantrolene	92-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131	
24764253-5	2015	By measuring the recoveries of enzyme activities after dilution of enzyme-inhibitor mixtures, it is further shown that dantrolene and ondansetron act as reversible AChE inhibitors.	Dantrolene	119-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168	
24764253-6	2015	CONCLUSIONS: By considering the typical plasma concentrations of dantrolene and ondansetron in humans at therapeutic doses, the pharmacological relevance of the AChE inhibitory potencies of these drugs is discussed.	Dantrolene	65-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	161-165	
24764253-9	2015	In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE.	Dantrolene	49-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-180	
24764253-9	2015	In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE.	Dantrolene	49-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	256-260	
24764253-9	2015	In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE.	Dantrolene	186-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-180	
24764253-9	2015	In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE.	Dantrolene	186-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	256-260	
24764253-10	2015	Further investigation is necessary to clarify the pharmacological relevance of the AChE inhibitory effect of dantrolene.	Dantrolene	109-119	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87