PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9585299-3	1998	In this study, we examined the effects of dantrolene on L-arginine transport and activity of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS) and interferon gamma (IFN-gamma) in rat alveolar macrophages.	Dantrolene	42-52	nitric oxide synthase 2	Rattus norvegicus	126-130	
9585299-8	1998	We conclude that the mechanisms by which dantrolene attenuated NO synthesis may be associated with the inhibition of availability of L-arginine by reducing the affinity for L-arginine, accompanied by a parallel decrease of the activity of iNOS.	Dantrolene	41-51	nitric oxide synthase 2	Rattus norvegicus	239-243	
9585299-7	1998	In addition, dantrolene also attenuated the activity of iNOS in a dose-dependent manner.	Dantrolene	13-23	nitric oxide synthase 2	Rattus norvegicus	56-60	
9579263-6	1998	RESULTS: In rats alveolar macrophages, (i) dantrolene (1 to 100 microM) caused a dose-dependent suppression of the production of nitrite and TNF-alpha induced by LPS (1 microgram.ml-1) plus IFN-gamma (100 u.ml-1) and (ii) dantrolene (100 microM) inhibited the activity (by 37 +/- 5%, P < 0.01) and protein expression (by 39 +/- 12%, P < 0.01) of iNOS in response to LPS plus IFN-gamma.	Dantrolene	43-53	nitric oxide synthase 2	Rattus norvegicus	352-356	
9579263-7	1998	CONCLUSION: Dantrolene inhibits NO production as well as the activity and expression of iNOS in alveolar macrophages treated with LPS plus IFN-gamma, which may be associated with the reduction of TNF-alpha production.	Dantrolene	12-22	nitric oxide synthase 2	Rattus norvegicus	88-92