PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9585299-3 1998 In this study, we examined the effects of dantrolene on L-arginine transport and activity of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS) and interferon gamma (IFN-gamma) in rat alveolar macrophages. Dantrolene 42-52 nitric oxide synthase 2 Rattus norvegicus 126-130 9585299-8 1998 We conclude that the mechanisms by which dantrolene attenuated NO synthesis may be associated with the inhibition of availability of L-arginine by reducing the affinity for L-arginine, accompanied by a parallel decrease of the activity of iNOS. Dantrolene 41-51 nitric oxide synthase 2 Rattus norvegicus 239-243 9585299-7 1998 In addition, dantrolene also attenuated the activity of iNOS in a dose-dependent manner. Dantrolene 13-23 nitric oxide synthase 2 Rattus norvegicus 56-60 9579263-6 1998 RESULTS: In rats alveolar macrophages, (i) dantrolene (1 to 100 microM) caused a dose-dependent suppression of the production of nitrite and TNF-alpha induced by LPS (1 microgram.ml-1) plus IFN-gamma (100 u.ml-1) and (ii) dantrolene (100 microM) inhibited the activity (by 37 +/- 5%, P < 0.01) and protein expression (by 39 +/- 12%, P < 0.01) of iNOS in response to LPS plus IFN-gamma. Dantrolene 43-53 nitric oxide synthase 2 Rattus norvegicus 352-356 9579263-7 1998 CONCLUSION: Dantrolene inhibits NO production as well as the activity and expression of iNOS in alveolar macrophages treated with LPS plus IFN-gamma, which may be associated with the reduction of TNF-alpha production. Dantrolene 12-22 nitric oxide synthase 2 Rattus norvegicus 88-92