PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17855623-0 2008 Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. Pyruvic Acid 110-118 uncoupling protein 2 Homo sapiens 0-20 26642043-0 2015 Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier. Pyruvic Acid 195-203 uncoupling protein 2 Homo sapiens 151-171 26642043-10 2015 These data are compatible with a model in which high UCP2 levels, together with a reduction in pyruvate transport due to the down-regulation of MPC, promote a shift from pyruvate to fatty acid oxidation, and to an uncoupling of glycolysis and oxidative phosphorylation. Pyruvic Acid 95-103 uncoupling protein 2 Homo sapiens 53-57 26642043-10 2015 These data are compatible with a model in which high UCP2 levels, together with a reduction in pyruvate transport due to the down-regulation of MPC, promote a shift from pyruvate to fatty acid oxidation, and to an uncoupling of glycolysis and oxidative phosphorylation. Pyruvic Acid 170-178 uncoupling protein 2 Homo sapiens 53-57 17855623-5 2008 Altogether, these results suggest that UCP2 promotes mitochondrial fatty acid oxidation while limiting mitochondrial catabolism of pyruvate. Pyruvic Acid 131-139 uncoupling protein 2 Homo sapiens 39-43 30556651-4 2019 UCP2 overexpression in skin epidermal cells enhances the incorporation of 13 C label to pyruvate, tricarboxylic acid cycle intermediates, nucleotides, and amino acids, suggesting that UCP2 upregulation reprograms cellular metabolism toward macromolecule synthesis. Pyruvic Acid 88-96 uncoupling protein 2 Homo sapiens 0-4 35044239-7 2022 CRITICAL ISSUES: Potential functions of UCP2 and UCP3 in striated muscles include a role in protection against mitochondria-dependent oxidative stress, as transporter for pyruvate, fatty acids and protons into and out of the mitochondria, and in metabolic sensing. Pyruvic Acid 171-179 uncoupling protein 2 Homo sapiens 40-44