PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19767525-0 2009 Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass. Pyruvic Acid 0-8 erythropoietin Sus scrofa 50-64 19767525-2 2009 Pyruvate reportedly suppresses degradation of the alpha-subunit of hypoxia-inducible factor-1 (HIF-1), an activator of the gene encoding the cardioprotective cytokine erythropoietin (EPO). Pyruvic Acid 0-8 erythropoietin Sus scrofa 167-181 19767525-2 2009 Pyruvate reportedly suppresses degradation of the alpha-subunit of hypoxia-inducible factor-1 (HIF-1), an activator of the gene encoding the cardioprotective cytokine erythropoietin (EPO). Pyruvic Acid 0-8 erythropoietin Sus scrofa 183-186 19767525-8 2009 Pyruvate-fortified cardioplegia stabilized arterial pressure post-CPB, induced myocardial EPO mRNA expression, and increased HIF-1alpha, EPO, and EPO-R protein contents by 60, 58, and 123%, respectively, vs. control cardioplegia (P < 0.05). Pyruvic Acid 0-8 erythropoietin Sus scrofa 90-93 19767525-8 2009 Pyruvate-fortified cardioplegia stabilized arterial pressure post-CPB, induced myocardial EPO mRNA expression, and increased HIF-1alpha, EPO, and EPO-R protein contents by 60, 58, and 123%, respectively, vs. control cardioplegia (P < 0.05). Pyruvic Acid 0-8 erythropoietin Sus scrofa 137-140 19767525-11 2009 Pyruvate-fortified cardioplegia induced myocardial EPO expression and mobilized the EPO-ERK-eNOS mechanism. Pyruvic Acid 0-8 erythropoietin Sus scrofa 51-54 19767525-11 2009 Pyruvate-fortified cardioplegia induced myocardial EPO expression and mobilized the EPO-ERK-eNOS mechanism. Pyruvic Acid 0-8 erythropoietin Sus scrofa 84-87 19767525-12 2009 By stabilizing HIF-1alpha, pyruvate-fortified cardioplegia may evoke sustained activation of EPO"s cardioprotective signaling cascade in myocardium. Pyruvic Acid 27-35 erythropoietin Sus scrofa 93-96