PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20598931-1 2010 Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism. Pyruvic Acid 95-103 pyruvate carboxylase Homo sapiens 0-20 20598931-1 2010 Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism. Pyruvic Acid 95-103 pyruvate carboxylase Homo sapiens 22-24 18686030-2 2009 PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain. Pyruvic Acid 30-38 pyruvate carboxylase Homo sapiens 0-2 12437512-3 2003 The mutation is located in the highly conserved pyruvate-binding domain of PC. Pyruvic Acid 48-56 pyruvate carboxylase Homo sapiens 75-77 18613815-1 2008 PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO(3)(-)- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate. Pyruvic Acid 4-12 pyruvate carboxylase Homo sapiens 0-2 16929648-4 2006 The addition of individual electron donors (acetate, pyruvate, and lactate) enhanced the dechlorination of PCB congeners under methanogenic and sulfate-reducing conditions but delayed the dechlorination of PCB congeners under nitrate-reducing conditions. Pyruvic Acid 53-61 pyruvate carboxylase Homo sapiens 107-110 16929648-4 2006 The addition of individual electron donors (acetate, pyruvate, and lactate) enhanced the dechlorination of PCB congeners under methanogenic and sulfate-reducing conditions but delayed the dechlorination of PCB congeners under nitrate-reducing conditions. Pyruvic Acid 53-61 pyruvate carboxylase Homo sapiens 206-209 14660628-6 2004 The reason was continued metabolism of pyruvate through pyruvate carboxylase (V(max), 83% of control) and diversion of flux through the pyruvate-malate shuttle. Pyruvic Acid 39-47 pyruvate carboxylase Homo sapiens 56-76 16505973-1 2006 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 71-79 pyruvate carboxylase Homo sapiens 0-20 16505973-1 2006 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 71-79 pyruvate carboxylase Homo sapiens 22-24 10229653-1 1999 Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 132-140 pyruvate carboxylase Homo sapiens 0-20 10229653-1 1999 Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 132-140 pyruvate carboxylase Homo sapiens 22-24 1980584-7 1990 Net synthesis of citric acid cycle intermediates is dependent on carbon dioxide fixation to pyruvate, catalyzed by pyruvate carboxylase (EC 6.4.1.1). Pyruvic Acid 92-100 pyruvate carboxylase Homo sapiens 115-135 9467236-3 1997 Gluconeogenesis from lactate and pyruvate is mediated through pyruvate carboxylase (PC) and phosphoenolpyruvate carboxykinase (PEPCK) activity. Pyruvic Acid 33-41 pyruvate carboxylase Homo sapiens 62-82 9467236-3 1997 Gluconeogenesis from lactate and pyruvate is mediated through pyruvate carboxylase (PC) and phosphoenolpyruvate carboxykinase (PEPCK) activity. Pyruvic Acid 33-41 pyruvate carboxylase Homo sapiens 84-86 9467236-4 1997 The PC mediated pathway depends on substrate supply and on the downregulation of the oxidative pathway for pyruvate. Pyruvic Acid 107-115 pyruvate carboxylase Homo sapiens 4-6 1415529-6 1992 Pyruvate was a more potent stimulator of ureagenesis than lactate and its effect less sensitive to pyruvate carboxylase inhibition. Pyruvic Acid 0-8 pyruvate carboxylase Homo sapiens 99-119 9585002-1 1998 Pyruvate carboxylase (PC) is a biotinylated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate. Pyruvic Acid 98-106 pyruvate carboxylase Homo sapiens 0-20 8884571-2 1996 Inborn deficiencies are known of each of the four enzymes of the glycolytic-gluconeogenic pathway that ensure a unidirectional flux from pyruvate to glucose: pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase, and glucose-6-phosphatase. Pyruvic Acid 137-145 pyruvate carboxylase Homo sapiens 158-178 34931827-1 2022 Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. Pyruvic Acid 72-80 pyruvate carboxylase Homo sapiens 101-121 3985180-1 1985 A mitochondrial model of gluconeogenesis and the tricarboxylic acid cycle, where pyruvate is metabolized via pyruvate carboxylase and pyruvate dehydrogenase, and pyruvate kinase is examined. Pyruvic Acid 81-89 pyruvate carboxylase Homo sapiens 109-129 34136384-5 2021 Pyruvate carboxylase (PC) is a major anaplerotic enzyme that catalyzes the carboxylation of pyruvate to form oxaloacetate, which has been suggested to be involved in the tumorigenesis of several cancers, including PTC. Pyruvic Acid 92-100 pyruvate carboxylase Homo sapiens 0-20 34150393-1 2021 Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis. Pyruvic Acid 35-43 pyruvate carboxylase Homo sapiens 0-20 34150393-1 2021 Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis. Pyruvic Acid 35-43 pyruvate carboxylase Homo sapiens 22-24 35122182-0 2022 Long noncoding RNA RP11-241J12.3 targeting pyruvate carboxylase promotes hepatocellular carcinoma aggressiveness by disrupting pyruvate metabolism and the DNA mismatch repair system. Pyruvic Acid 127-135 pyruvate carboxylase Homo sapiens 43-63 35122182-5 2022 The results showed that RP11-241J12.3 not only accelerated DNA synthesis and upregulated the expression of pyruvate carboxylase (PC) and MSH3, which is a key protein in pyruvate metabolism and DNA mismatch repair (MMR), but also promoted tumor growth in vitro and in vivo, thus promoting HCC aggressiveness. Pyruvic Acid 169-177 pyruvate carboxylase Homo sapiens 107-127 3091918-7 1986 Oxaloacetate is primarily generated by the carboxylation of pyruvate catalysed by pyruvate carboxylase. Pyruvic Acid 60-68 pyruvate carboxylase Homo sapiens 82-102 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Pyruvic Acid 102-110 pyruvate carboxylase Homo sapiens 0-20 8990-9 1976 The PC preparation was shown to have an absolute requirement for CoASAc, contained biotin, was not inhibited by lipoate, and had an apparent Km approximately equal to 3.6 X 10(-4) M for pyruvate. Pyruvic Acid 186-194 pyruvate carboxylase Homo sapiens 4-6 939224-1 1976 Kinetic methods have been used to determine the interrelationship between HCO-3, pyruvate and acetyl-CoA and their effect on pigeon kidney pyruvate carboxylase (pyruvate: CO2 ligase [ADP], EC 6.4.1.1). Pyruvic Acid 81-89 pyruvate carboxylase Homo sapiens 139-159 1147984-0 1975 Pyruvate carboxylase: affinity labelling of the pyruvate binding site. Pyruvic Acid 48-56 pyruvate carboxylase Homo sapiens 0-20 19396987-7 1974 (3) p-Chlorophenyl pyruvate, an inhibitor of pyruvate carboxylase (pyruvate: carbondioxide ligase, ADP, EC 6.4.1.1), also inhibited lactate production from pyruvate. Pyruvic Acid 19-27 pyruvate carboxylase Homo sapiens 45-65 19396987-8 1974 (4) It is postulated that with pyruvate as substrate, recycling of carbon via pyruvate carboxylase, phosphoenolpyruvate carboxylase and pyruvate kinase (ATP: pyruvate phosphotransferase, EC 2.7.1.40) is an important, energy-requiring, mechanism for the transfer of the proportion of NADH not directly associated with gluconeogenesis. Pyruvic Acid 31-39 pyruvate carboxylase Homo sapiens 78-98 4348015-0 1973 Interaction of pyruvate with pyruvate carboxylase and pyruvate kinase as studied by paramagnetic effects on 13 C relaxation rates. Pyruvic Acid 15-23 pyruvate carboxylase Homo sapiens 29-49 34057673-2 2021 Astrocytes synthesize glutamate de novo owing to the pyruvate entry to the citric/tricarboxylic acid cycle via pyruvate carboxylase, an astrocyte specific enzyme. Pyruvic Acid 53-61 pyruvate carboxylase Homo sapiens 111-131 7362856-2 1980 These mitochondria have a large capacity to flux pyruvate through the pyruvate carboxylase reaction causing an accumulation of malate, citrate and phosphoenolpyruvate. Pyruvic Acid 49-57 pyruvate carboxylase Homo sapiens 70-90 7362856-3 1980 As much as 70% of the pyruvate utilized during state 3 respiration can flux through the pyruvate carboxylase reaction. Pyruvic Acid 22-30 pyruvate carboxylase Homo sapiens 88-108 14162694-0 1964 PYRUVATE METABOLISM AND CONTROL: FACTORS AFFECTING PYRUVIC CARBOXYLASE ACTIVITY. Pyruvic Acid 0-8 pyruvate carboxylase Homo sapiens 51-70 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Pyruvic Acid 102-110 pyruvate carboxylase Homo sapiens 22-24 33880999-1 2021 Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism. Pyruvic Acid 68-76 pyruvate carboxylase Homo sapiens 0-20 33880999-1 2021 Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism. Pyruvic Acid 68-76 pyruvate carboxylase Homo sapiens 22-24 30949058-7 2019 Pyruvate either enters the citric acid cycle through pyruvate dehydrogenase or is carboxylated by pyruvate carboxylase. Pyruvic Acid 0-8 pyruvate carboxylase Homo sapiens 98-118 31697914-1 2019 Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate. Pyruvic Acid 70-78 pyruvate carboxylase Homo sapiens 0-20 31697914-1 2019 Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate. Pyruvic Acid 70-78 pyruvate carboxylase Homo sapiens 22-24 31180060-1 2019 Pyruvate carboxylase (Pyc) catalyzes formation of oxaloacetic acid from pyruvic acid by fixing one mole of CO2. Pyruvic Acid 72-84 pyruvate carboxylase Homo sapiens 0-20 31180060-1 2019 Pyruvate carboxylase (Pyc) catalyzes formation of oxaloacetic acid from pyruvic acid by fixing one mole of CO2. Pyruvic Acid 72-84 pyruvate carboxylase Homo sapiens 22-25 27068034-9 2017 In astrocytes, pyruvate entered the TCA cycle mostly through pyruvate carboxylase (81%). Pyruvic Acid 15-23 pyruvate carboxylase Homo sapiens 61-81 30045381-1 2018 Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle. Pyruvic Acid 134-142 pyruvate carboxylase Homo sapiens 0-20 30045381-1 2018 Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle. Pyruvic Acid 134-142 pyruvate carboxylase Homo sapiens 22-24 30005601-4 2018 Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle. Pyruvic Acid 54-62 pyruvate carboxylase Homo sapiens 0-20 30005601-4 2018 Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle. Pyruvic Acid 54-62 pyruvate carboxylase Homo sapiens 22-24 27890529-9 2017 The data indicate that the major metabolic roles of PC in invasive breast cancer are primarily anaplerosis, pyruvate cycling and mitochondrial biosynthesis of precursors of cellular components required for breast cancer cell growth and replication. Pyruvic Acid 108-116 pyruvate carboxylase Homo sapiens 52-54 29643369-1 2018 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 71-79 pyruvate carboxylase Homo sapiens 0-20 29643369-1 2018 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 71-79 pyruvate carboxylase Homo sapiens 22-24 27732858-2 2016 The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to alpha-ketoglutarate. Pyruvic Acid 48-56 pyruvate carboxylase Homo sapiens 88-108 27732858-2 2016 The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to alpha-ketoglutarate. Pyruvic Acid 48-56 pyruvate carboxylase Homo sapiens 110-112 27732858-7 2016 Based on in vitro analysis and a mathematical model for the determination of compartment-specific metabolite concentrations, we found that mitochondrial pyruvate concentrations can promote PC-dependent anaplerosis via enzyme kinetics. Pyruvic Acid 153-161 pyruvate carboxylase Homo sapiens 189-191 27254467-4 2016 For example, pyruvate binding to the carboxyl transferase (CT) domain of pyruvate carboxylase (PC) increases the rate of product release in the biotin carboxylase (BC) domain. Pyruvic Acid 13-21 pyruvate carboxylase Homo sapiens 73-93 24363178-4 2014 Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux. Pyruvic Acid 14-22 pyruvate carboxylase Homo sapiens 157-177 27885626-5 2016 This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. Pyruvic Acid 63-71 pyruvate carboxylase Homo sapiens 99-119 26070193-1 2015 Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. Pyruvic Acid 87-95 pyruvate carboxylase Homo sapiens 0-20 26070193-1 2015 Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. Pyruvic Acid 87-95 pyruvate carboxylase Homo sapiens 22-24 25607840-2 2015 The major anaplerotic sources are pyruvate and glutamine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively. Pyruvic Acid 34-42 pyruvate carboxylase Homo sapiens 88-108 25607840-2 2015 The major anaplerotic sources are pyruvate and glutamine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively. Pyruvic Acid 34-42 pyruvate carboxylase Homo sapiens 110-112 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Pyruvic Acid 103-111 pyruvate carboxylase Homo sapiens 0-20 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Pyruvic Acid 103-111 pyruvate carboxylase Homo sapiens 22-24 25243911-7 2014 Flux of pyruvate via PC and via pyruvate dehydrogenase (PDH) was determined by using magnetic resonance spectroscopy to probe the labeling of [2-13C]glucose-derived 13C-labeled glutamate and glutamine. Pyruvic Acid 8-16 pyruvate carboxylase Homo sapiens 21-23 24476417-2 2014 Through initial velocity, product inhibition, isotopic exchange and alternate substrate experiments, early investigators established that PC catalyzes the MgATP-dependent carboxylation of pyruvate by HCO3 (-) through a nonclassical sequential Bi Bi Uni Uni reaction mechanism. Pyruvic Acid 188-196 pyruvate carboxylase Homo sapiens 138-140 23098296-1 2012 Pyruvate carboxylase [EC 6.4.1.1] plays an important anaplerotic role in many species by catalyzing the carboxylation of pyruvate to oxaloacetate. Pyruvic Acid 121-129 pyruvate carboxylase Homo sapiens 0-20 23698000-2 2013 Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. Pyruvic Acid 134-142 pyruvate carboxylase Homo sapiens 0-20 23698000-2 2013 Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. Pyruvic Acid 134-142 pyruvate carboxylase Homo sapiens 22-24 21454710-5 2011 In line with the lower PC, the percentage of glucose-derived pyruvate that entered mitochondrial metabolism via carboxylation in human islets was only 20-30% that in rat islets. Pyruvic Acid 61-69 pyruvate carboxylase Homo sapiens 23-25 21958016-1 2011 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. Pyruvic Acid 71-79 pyruvate carboxylase Homo sapiens 0-20 20807508-1 2010 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. Pyruvic Acid 88-96 pyruvate carboxylase Homo sapiens 0-20 20807508-1 2010 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. Pyruvic Acid 88-96 pyruvate carboxylase Homo sapiens 22-24