PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33463481-7	2022	For example, glibenclamide exerts an anti-inflammatory effect in respiratory, digestive, urological, and central nervous system (CNS) diseases, as well as in ischemia-reperfusion injury associated with abnormal SUR1-Trpm4/TNF-alpha or SUR1-Trpm4/ Nos2/ROS signaling.	Glyburide	13-26	tumor necrosis factor	Homo sapiens	222-231	
16861224-4	2006	Moreover, TNF-alpha-mediated MIF release was blocked by glyburide and propenicide, both inhibitors of ATP-binding cassette-type transporters, suggesting that this transporter system is activated during neutrophil apoptosis.	Glyburide	56-65	tumor necrosis factor	Homo sapiens	10-19	
11676825-11	2001	In human dermal fibroblasts that were stimulated with tumor necrosis factor alpha to reach high interleukin-1 expression levels, glybenclamide similarly suppressed interleukin-8.	Glyburide	129-142	tumor necrosis factor	Homo sapiens	54-81	
17097222-7	2007	The C16:0 sulfatide has been shown to activate potassium channels in beta-cells, and glibenclamide, an ATP-sensitive K+-(KATP) channel blocker, reversed the C16:0-induced decrement in stimulated TNF-alpha, IL-6, and IL-8 release in adipocytes.	Glyburide	85-98	tumor necrosis factor	Homo sapiens	195-204	
21925514-5	2011	KEY FINDINGS: In heparinized blood, glibenclamide reduced LPS-induced release of IL-1 beta and TNF-alpha, tissue factor and PAI-2 mRNA in a concentration-dependent manner.	Glyburide	36-49	tumor necrosis factor	Homo sapiens	95-104	
30283449-7	2018	We found that glibenclamide significantly reduced M1 (HLA-DR+ and CD86+) surface markers and TNF-alpha production on primary human monocytes against mycobacterial infection.	Glyburide	14-27	tumor necrosis factor	Homo sapiens	93-102	
26581714-9	2015	At 30 days, the lumbar spinal cords of glibenclamide-treated WT/EAE and Abcc8-/-/EAE mice showed significantly fewer invading immune cells, including leukocytes (CD45), T cells (CD3), B cells (CD20) and macrophages/microglia (CD11b), and fewer cells expressing pro-inflammatory cytokines (TNF-alpha, IFN-gamma, IL-17).	Glyburide	39-52	tumor necrosis factor	Homo sapiens	289-298	
28740332-4	2017	Glibenclamide might block KATP channel, Sur1-Trpm4 channel, and NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation, decrease the production of proinflammatory mediators (TNF-alpha, IL-1beta, and reactive oxygen species), and suppress the accumulation of inflammatory cells.	Glyburide	0-13	tumor necrosis factor	Homo sapiens	195-204