PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11805217-9 2002 Simultaneous inhibition of PDE5, 6, and 9 (zaprinast), purported to specifically elevate intracellular cGMP, reduced, in a dose-independent manner, IL-6 and TNF-alpha biosynthesis. zaprinast 43-52 interleukin 6 Homo sapiens 148-152 22561121-10 2012 LPS induced the mRNA expressions of IL-1beta, TNF-alpha, IL-6, CCL2, iNOS, and COX-2, and although zaprinast significantly induced the expressions of all except IL-6 and iNOS, these inductions were far less than those induced by LPS. zaprinast 99-108 interleukin 6 Homo sapiens 161-165