PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16423372-9	2006	Western blot analysis revealed that telithromycin significantly decreased the protein levels of CYP1A2 and CYP3A2 in the liver, which could explain the observed decreases in the systemic clearance of theophylline and metabolic clearance of 1-methyluric acid and 1,3-dimethyluric acid.	Theophylline	200-212	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	107-113	
16423372-10	2006	The present study suggests that telithromycin at the dose used in this study alters the pharmacokinetics and metabolism of theophylline, due to reductions in the activity and expression of hepatic CYP1A2 and CYP3A2.	Theophylline	123-135	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	208-214	
15988118-0	2005	Prediction of theophylline clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test.	Theophylline	14-26	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	83-89	
15988118-6	2005	The qg value of CYP3A2 estimated with MDZ as a probe was used together with our previously reported value for CYP1A2 (theophylline metabolism in the liver is known to be almost entirely mediated by CYP3A2 and CYP1A2) to predict the total body clearance (CL(tot)) of theophylline in CCl4-treated rats.	Theophylline	118-130	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	16-22	
15988118-6	2005	The qg value of CYP3A2 estimated with MDZ as a probe was used together with our previously reported value for CYP1A2 (theophylline metabolism in the liver is known to be almost entirely mediated by CYP3A2 and CYP1A2) to predict the total body clearance (CL(tot)) of theophylline in CCl4-treated rats.	Theophylline	118-130	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	198-204	
15988118-6	2005	The qg value of CYP3A2 estimated with MDZ as a probe was used together with our previously reported value for CYP1A2 (theophylline metabolism in the liver is known to be almost entirely mediated by CYP3A2 and CYP1A2) to predict the total body clearance (CL(tot)) of theophylline in CCl4-treated rats.	Theophylline	266-278	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	16-22	
15988118-6	2005	The qg value of CYP3A2 estimated with MDZ as a probe was used together with our previously reported value for CYP1A2 (theophylline metabolism in the liver is known to be almost entirely mediated by CYP3A2 and CYP1A2) to predict the total body clearance (CL(tot)) of theophylline in CCl4-treated rats.	Theophylline	266-278	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	198-204	
15618669-0	2002	Simultaneous assessment of the in vivo amount of CYP1A2 and CYP3A2 by the PKCYP-test using theophylline in rats.	Theophylline	91-103	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	60-66	
29979512-2	2017	Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphanwere used as substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1, and CYP2D2 to test the depressionimpact on drug metabolism.	Theophylline	28-40	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	135-141