PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16624439-7 2006 Addition of the aldose reductase inhibitor SNK-860 dose-dependently decreased the intracellular sorbitol concentration in HUVECs incubated in high glucose medium, and also significantly suppressed the increases in fragmented DNA, caspase-3 activity and 8-OHdG by conditioning with high glucose medium. Sorbitol 96-104 polo like kinase 2 Homo sapiens 43-46 12039395-0 2002 Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients. Sorbitol 83-91 polo like kinase 2 Homo sapiens 12-15 15531183-0 2004 Erythrocytic sorbitol contents in diabetic patients correlate with blood aldose reductase protein contents and plasma glucose levels, and are normalized by the potent aldose reductase inhibitor fidarestat (SNK-860). Sorbitol 13-21 polo like kinase 2 Homo sapiens 206-209 7648800-4 1995 The addition of 10 mumol l-1 SNK normalized the increased sorbitol levels in neutrophils exposed to 40 mmol l-1 glucose and improved, but did not normalize, the decrease in CL induced by 40 mmol l-1 glucose (p < 0.001). Sorbitol 58-66 polo like kinase 2 Homo sapiens 29-32