PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6873202-3 1983 Since NADPH is primarily consumed by glutathione reductase, which in conjunction with glutathione peroxidase detoxifies H2O2 present in the aqueous humor, the cataractogenic role of sorbitol-induced osmotic pressure must therefore depend on the availability of NADPH for aldose reductase activity. Sorbitol 182-190 glutathione-disulfide reductase Homo sapiens 37-58 8052153-3 1994 The NADPH used by glutathione reductase for the reduction of oxidized glutathione (GSSG) to GSH is also used by aldose reductase for the reduction of glucose to sorbitol through the polyol pathway. Sorbitol 161-169 glutathione-disulfide reductase Homo sapiens 18-39