PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28357334-2 2016 This is due to concomitant relief of carbon catabolite repression (CCR) and activation of mitochondrial retrograde signaling, a mitochondria-to-nucleus communication pathway causing up-regulation of various nuclear target genes, such as CIT2, encoding peroxisomal citrate synthase, dependent on the positive regulator RTG2 in response to mitochondrial dysfunction. carbon catabolite 37-54 Rtg2p Saccharomyces cerevisiae S288C 318-322