PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27118044-7 2016 Although there is no evidence that AML pathophysiology is related to hypoxia, leukemic blasts still show several distinct biological features when exposed to reduced pO2: they down- or upregulate membrane receptors such as CXCR4 or FLT3, activate or inhibit intracellular signaling pathways such as PI3K, and specifically secrete cytokines (IL-8). PO-2 166-169 fms related receptor tyrosine kinase 3 Homo sapiens 232-236