PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17424908-7	2006	CR protects the rat aorta from the age-related increase of both oxidative damage and fibrosis; as regards the possible mechanism/s of CR"s protection against fibrosclerosis, it is conceivable that, by decreasing oxidative stress, CR reduces HNE levels and consequently TGFbeta1 expression and collagen deposition, likely by down-regulating the activation of Jun-N terminal kinase and of AP-1.	Chromium	0-2	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	387-391	
19199090-8	2009	CR also inhibited upstream signaling cascades and DNA binding activity of NF-kB and AP-1, and thioredoxin/Ref-1 pathway.	Chromium	0-2	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-88	
19199090-9	2009	CR blocked expression of NF-kB-and AP-1-responsive gene COX-2, iNOS, VCAM-1 and ICAM-1.	Chromium	0-2	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-39	
19199090-10	2009	CONCLUSIONS: We report for the first time that 10-day CR can attenuate the altered signaling transduction for inflammatory processes which is mediated through RS-induced NF-kB and AP-1 in aged kidney.	Chromium	54-56	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	180-184	
17424908-7	2006	CR protects the rat aorta from the age-related increase of both oxidative damage and fibrosis; as regards the possible mechanism/s of CR"s protection against fibrosclerosis, it is conceivable that, by decreasing oxidative stress, CR reduces HNE levels and consequently TGFbeta1 expression and collagen deposition, likely by down-regulating the activation of Jun-N terminal kinase and of AP-1.	Chromium	134-136	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	387-391	
17424908-7	2006	CR protects the rat aorta from the age-related increase of both oxidative damage and fibrosis; as regards the possible mechanism/s of CR"s protection against fibrosclerosis, it is conceivable that, by decreasing oxidative stress, CR reduces HNE levels and consequently TGFbeta1 expression and collagen deposition, likely by down-regulating the activation of Jun-N terminal kinase and of AP-1.	Chromium	134-136	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	387-391	
23604908-8	2002	For CR"s action, we found that in the nucleus of aged rats, AP-1 activation was blunted by decreasing c-Jun and c-Fos levels and inhibiting c-Jun protein phosphorylation.	Chromium	4-6	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-64	
23604908-10	2002	Based on the data of these findings, we concluded that AP-1 activity increases in rat kidney with age and that CR reduces AP-1 activity.	Chromium	111-113	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-126