PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31152816-7	2019	These outcomes support the hypothesis that the miR-143/IL-6/HIF-1alpha pathway functions to regulate Cr(VI)-induced carcinogenesis.	Chromium	101-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70	
18927491-7	2008	Moreover, CR 3294 inhibited both the DNA binding of HIF-1alpha and VEGF mRNA synthesis.	Chromium	10-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62	
18927491-10	2008	In particular, 3 methyladenine (3MA) and wortmannin, two macroautophagic inhibitors, prevented both the decrease of HIF-1alpha protein levels and LC3 processing in cells treated with CR 3294.	Chromium	183-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126	
12470896-8	2002	Age-related increases in redox-sensitive NF-kappaB, AP-1, and HIF-1 binding activities are concluded to be associated with increased ROS and CR to modulate their activations by suppressing oxidative stress.	Chromium	141-143	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67	
31432135-9	2019	In addition, CR, EM and WM raised the expression of angiogenesis-associated genes and HIF-1alpha, thereby promoting in vitro tube formation of primary endothelial cells.	Chromium	13-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96	
17382205-5	2007	Here we investigated the induction of HIF-1 by another metal, chromium, which cannot replace iron in the enzyme.	Chromium	62-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-43	
17382205-7	2007	In agreement with these data chromium(VI) stabilizes HIF-1alpha protein in cells only until it is reduced to chromium(III).	Chromium	29-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63	
17382205-11	2007	However, repeated (chronic) exposure to chromium(VI) can also lead to extended stabilization of HIF-1alpha.	Chromium	40-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106	
27226640-8	2016	Hypoxia-inducible factor-1alpha, pro-angiogenic protein matrix metalloproteinase 1, and VEGF are all highly expressed in Cr(VI)-transformed cells, in lung tissue from animals exposed to Cr(VI), and in lung tumor tissue from a non-smoking worker occupationally exposed to Cr(VI) for 19 years.	Chromium	121-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31	
27226640-8	2016	Hypoxia-inducible factor-1alpha, pro-angiogenic protein matrix metalloproteinase 1, and VEGF are all highly expressed in Cr(VI)-transformed cells, in lung tissue from animals exposed to Cr(VI), and in lung tumor tissue from a non-smoking worker occupationally exposed to Cr(VI) for 19 years.	Chromium	186-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31	
27226640-8	2016	Hypoxia-inducible factor-1alpha, pro-angiogenic protein matrix metalloproteinase 1, and VEGF are all highly expressed in Cr(VI)-transformed cells, in lung tissue from animals exposed to Cr(VI), and in lung tumor tissue from a non-smoking worker occupationally exposed to Cr(VI) for 19 years.	Chromium	186-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31