PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23195617-7 2013 RESULTS: Patients with SLC28A2 rs11854484 genotype TT had higher dosage- and body weight-adjusted RBV levels than those with genotypes TC or CC (p=0.02 and p=0.06 at weeks 4 and 8, respectively). Ribavirin 98-101 solute carrier family 28 member 2 Homo sapiens 23-30 24957263-0 2014 Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-alpha via up-regulation of the human concentrative nucleoside transporter (hCNT2). Ribavirin 0-9 solute carrier family 28 member 2 Homo sapiens 151-156 24957263-3 2014 hCNT2 is the best candidate to mediate ribavirin uptake into hepatocytes due to its high-affinity for purines and its capacity to concentrate its substrates intracellularly. Ribavirin 39-48 solute carrier family 28 member 2 Homo sapiens 0-5 24957263-6 2014 hCNT2 activity up-regulation was associated with increased ribavirin accumulation into cells. Ribavirin 59-68 solute carrier family 28 member 2 Homo sapiens 0-5 23195617-10 2013 CONCLUSIONS: The newly identified association between RBV serum levels and SLC28A2 rs11854484 genotype, as well as the replicated association of ITPA and SLC28A3 genetic polymorphisms with RBV-induced anemia and treatment response, may support individualized treatment of chronic hepatitis C and warrant further investigation in larger studies. Ribavirin 54-57 solute carrier family 28 member 2 Homo sapiens 75-82 17700367-6 2007 Expression of these variants in U-251 cells revealed that all except E385K can uptake various substrates of hCNT2: inosine, ribavirin and uridine. Ribavirin 124-133 solute carrier family 28 member 2 Homo sapiens 108-113 19369574-1 2009 Ribavirin is found to be absorbed in the intestine through the human concentrative nucleoside transporter 2 (hCNT2). Ribavirin 0-9 solute carrier family 28 member 2 Homo sapiens 69-107 19369574-1 2009 Ribavirin is found to be absorbed in the intestine through the human concentrative nucleoside transporter 2 (hCNT2). Ribavirin 0-9 solute carrier family 28 member 2 Homo sapiens 109-114 17140564-4 2007 In Xenopus oocytes, influxes of ribavirin mediated by hCNT2 (concentrative nucleoside transporter 2), hCNT3 (concentrative nucleoside transporter 3), hENT1 (equilibrative nucleoside transporter 1) and hENT2 (equilibrative nucleoside transporter 2) were saturable, and apparent K(m) values were 18.0 microM, 14.2 microM, 3.46 mM and 3.71 mM, respectively. Ribavirin 32-41 solute carrier family 28 member 2 Homo sapiens 54-59 17140564-5 2007 These data indicate that hCNT2 and hCNT3 have higher affinity for ribavirin than do hENT1 and hENT2. Ribavirin 66-75 solute carrier family 28 member 2 Homo sapiens 25-30 26952879-4 2016 As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. Ribavirin 3-12 solute carrier family 28 member 2 Homo sapiens 85-90 32864162-6 2020 We found several drug-gene variant pairs that may alter the pharmacokinetics of hydroxychloroquine/chloroquine (CYP2C8, CYP2D6, SLCO1A2, and SLCO1B1); azithromycin (ABCB1); ribavirin (SLC29A1, SLC28A2, and SLC28A3); and lopinavir/ritonavir (SLCO1B1, ABCC2, CYP3A). Ribavirin 173-182 solute carrier family 28 member 2 Homo sapiens 193-200 31810127-1 2020 PURPOSE: This study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) of genes involved in ribavirin (RBV) transport (SLC28A2 gene, ABCB1 gene and ABCB11 gene) on the clinical outcome and pharmacokinetics of ribavirin in HCV- 4 Egyptian patients. Ribavirin 115-124 solute carrier family 28 member 2 Homo sapiens 142-149 31810127-1 2020 PURPOSE: This study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) of genes involved in ribavirin (RBV) transport (SLC28A2 gene, ABCB1 gene and ABCB11 gene) on the clinical outcome and pharmacokinetics of ribavirin in HCV- 4 Egyptian patients. Ribavirin 126-129 solute carrier family 28 member 2 Homo sapiens 142-149 26071337-0 2015 Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment. Ribavirin 100-109 solute carrier family 28 member 2 Homo sapiens 17-24 25661337-1 2015 Ribavirin is phosphorylated by adenosine kinase 1 (AK1) and cytosolic 5"-nucleotidase 2 and it is transported into cells by concentrative nucleoside transporters (CNT) 2/3, coded by SLC28A2/3 genes, and equilibrative nucleoside transporters (ENT) 1/2, coded by SLC29A1/2 genes. Ribavirin 0-9 solute carrier family 28 member 2 Homo sapiens 182-189 25661337-5 2015 Concerning ribavirin pharmacokinetics, SLC28A2_rs11854488 TT was related to lower Ctrough levels; conversely patients with TC profile of SLC28A3_rs10868138 and SLC29A1_rs760370 GG genotype had higher ribavirin levels. Ribavirin 11-20 solute carrier family 28 member 2 Homo sapiens 39-46 25661337-5 2015 Concerning ribavirin pharmacokinetics, SLC28A2_rs11854488 TT was related to lower Ctrough levels; conversely patients with TC profile of SLC28A3_rs10868138 and SLC29A1_rs760370 GG genotype had higher ribavirin levels. Ribavirin 200-209 solute carrier family 28 member 2 Homo sapiens 39-46 25661339-3 2015 The aim of this retrospective study was the evaluation of the influence of some single nucleotide polymorphisms (SNPs) of genes (ABCB1, SLC28A2/3, SLC29A1) involved in TLV and RBV transport and their correlation with plasma TLV drug exposure at 1 month of therapy. Ribavirin 176-179 solute carrier family 28 member 2 Homo sapiens 136-145