PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33035507-11 2020 Taken together, this study demonstrates that 3-DA inhibits AP-1 and NF-kappaB signaling by directly blocking MEK1/2 and IKKalpha/beta or indirectly mediating SAHH, resulting in anti-inflammatory activity. 3-da 45-49 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 59-63 33035507-5 2020 Moreover, 3-DA strongly blocked AP-1 and NF-kappaB luciferase activity under PMA-, MyD88-, and TRIF-stimulated conditions and decreased the translocation of c-Jun, c-Fos, p65, and p50 into the nucleus. 3-da 10-14 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 32-36 33035507-5 2020 Moreover, 3-DA strongly blocked AP-1 and NF-kappaB luciferase activity under PMA-, MyD88-, and TRIF-stimulated conditions and decreased the translocation of c-Jun, c-Fos, p65, and p50 into the nucleus. 3-da 10-14 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 157-162 33035507-6 2020 In addition, the p-ERK level in AP-1 signaling and the p-IkappaBalpha level in NF-kB signaling were diminished by 3-DA treatment. 3-da 114-118 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 32-36