PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15255937-0	2004	The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	20-26	mitogen-activated protein kinase 1	Homo sapiens	119-122	
15255937-4	2004	In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	62-68	mitogen-activated protein kinase 1	Homo sapiens	172-175	
15255937-6	2004	PD98059 and U0126, two distinct inhibitors of MEK, block the activation of ERK by GW5074 but have no effect on its ability to prevent cell death.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	82-88	mitogen-activated protein kinase 1	Homo sapiens	75-78	
26578388-10	2015	GW5074 (Raf-1 inhibitor) upregulated the expression of phospho-ERK, but had no effect on phospho-Akt.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	0-6	mitogen-activated protein kinase 1	Homo sapiens	63-66	
19288477-6	2009	US-induced MEK and ERK activation was inhibited by manumycin A, GW5074, and PD98059.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	64-70	mitogen-activated protein kinase 1	Homo sapiens	19-22	
23708800-7	2013	U0126 and GW5074 suppress the induction of Bag-1 by Chlamydia, implying that Chlamydia may up-regulate Bag-1 via the MAPK/ERK survival pathway.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	10-16	mitogen-activated protein kinase 1	Homo sapiens	122-125