PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23635803-0 2013 ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Disulfiram 35-45 ankyrin repeat and kinase domain containing 1 Homo sapiens 0-5 23635803-2 2013 Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. Disulfiram 269-279 ankyrin repeat and kinase domain containing 1 Homo sapiens 129-174 23635803-6 2013 RESULTS: Patients with CT or TT ANKK1 genotypes dropped from 80 to 52% cocaine-positive urines on disulfiram (N=13; P<=0.0001), whereas those on placebo (N=20) showed no treatment effect. Disulfiram 98-108 ankyrin repeat and kinase domain containing 1 Homo sapiens 32-37 23635803-10 2013 CONCLUSION: A patient"s genotype for ANKK1, DRD2, or both, may be used to identify individuals for whom disulfiram may be an effective pharmacotherapy for cocaine dependence. Disulfiram 104-114 ankyrin repeat and kinase domain containing 1 Homo sapiens 37-42