PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15551062-16 2005 ALDH1 is the predominant isoform in rat liver and skin cytosolic fractions that is selectively inhibited by disulfiram and responds to the amount of aldehyde formed by the ADH isoforms expressed in these tissues. Disulfiram 108-118 aldehyde dehydrogenase 2 family member Rattus norvegicus 0-5 9586946-16 1998 Thus, even if DETC-MeSO2 is formed in vivo from DETC-MeSO, it is the metabolite DETC-MeSO that is most likely responsible for the inhibition of ALDH2 after disulfiram administration. Disulfiram 156-166 aldehyde dehydrogenase 2 family member Rattus norvegicus 144-149 7840792-13 1995 In conclusion, thiocarbamate herbicides inhibit ALDH2, probably due to the formation of their sulfoxide, and therefore have the potential to produce a disulfiram-like ethanol reaction in an unsuspecting population. Disulfiram 151-161 aldehyde dehydrogenase 2 family member Rattus norvegicus 48-53 7978080-1 1994 S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO) is a potent inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase (ALDH2) both in vivo and in vitro, and has been proposed to be the metabolite responsible for ALDH2 inhibition by disulfiram. Disulfiram 250-260 aldehyde dehydrogenase 2 family member Rattus norvegicus 137-142 6870943-1 1983 The inhibition of the low-Km, rat-liver mitochondrial aldehyde dehydrogenase (ALDH) by the alcohol-sensitizing agents cyanamide, 1-aminocyclopropanol (ACP) and disulfiram was studied in vitro. Disulfiram 160-170 aldehyde dehydrogenase 2 family member Rattus norvegicus 40-76 10974203-0 2000 Role of disulfiram in the in vitro inhibition of rat liver mitochondrial aldehyde dehydrogenase. Disulfiram 8-18 aldehyde dehydrogenase 2 family member Rattus norvegicus 59-95 7853193-1 1995 Disulfiram is bioactivated through a series of intermediates, ultimately forming S-methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-Me sulfoxide), the metabolite proposed to be responsible for the in vivo inhibition of rat liver mitochondrial low Km aldehyde dehydrogenase (ALDH2). Disulfiram 0-10 aldehyde dehydrogenase 2 family member Rattus norvegicus 274-279 28017615-2 2017 Previously, we reported that an ALDH inhibitor, disulfiram caused bone loss in rats and among ALDHs, osteoblast expressed only ALDH2. Disulfiram 48-58 aldehyde dehydrogenase 2 family member Rattus norvegicus 127-132