PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34482117-0	2021	Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis.	Disulfiram	104-114	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45	
34482117-9	2021	Notably, inhibition of NRF2 expression via RNA interference or pharmacological inhibitors significantly facilitated the accumulation of lipid peroxidation, and rendered HCC cells more sensitive to DSF/Cu induced ferroptosis.	Disulfiram	197-200	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27	
34482117-11	2021	Additionally, DSF/Cu could strengthen the cytotoxicity of sorafenib, and arrest tumor growth both in vitro and in vivo, by simultaneously inhibiting the signal pathway of NRF2 and MAPK kinase.	Disulfiram	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175	
34482117-12	2021	In summary, these results provide experimental evidence that inhibition of the compensatory NRF2 elevation strengthens HCC cells more vulnerable to DSF/Cu induced ferroptosis, which facilitates the synergistic cytotoxicity of DSF/Cu and sorafenib.	Disulfiram	148-151	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96	
34482117-12	2021	In summary, these results provide experimental evidence that inhibition of the compensatory NRF2 elevation strengthens HCC cells more vulnerable to DSF/Cu induced ferroptosis, which facilitates the synergistic cytotoxicity of DSF/Cu and sorafenib.	Disulfiram	226-229	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96	
28518151-0	2017	Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kappaB and Nrf2.	Disulfiram	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159	
28518151-8	2017	Mechanistically, DS/Cu-induced cytotoxicity was closely associated with activation of the stress-related ROS-JNK pathway as well as simultaneous inactivation of the pro-survival Nrf2 and nuclear factor-kappaB pathways.	Disulfiram	17-19	NFE2 like bZIP transcription factor 2	Homo sapiens	178-182	
24915933-0	2014	Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition.	Disulfiram	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89	
24915933-11	2014	After 24 h exposure, DS/Cu inhibits Nrf2 expression.	Disulfiram	21-23	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40	
24915933-13	2014	DS/Cu induced phosphorylation of JNK and inhibits p65 expression as well as Nrf2 expression both in vitro and in vivo.	Disulfiram	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80	
24915933-18	2014	Moreover, ROS-related activation of JNK pathway and inhibition of NF-kappaB and Nrf2 may also contribute to the DS/Cu induced apoptosis.	Disulfiram	112-114	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84