PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32145587-0	2020	Disulfiram/copper markedly induced myeloma cell apoptosis through activation of JNK and intrinsic and extrinsic apoptosis pathways.	Disulfiram	0-10	mitogen-activated protein kinase 8	Homo sapiens	80-83	
33792698-0	2021	The disulfiram/copper complex induces apoptosis and inhibits tumor growth in human osteosarcoma by activating the ROS/JNK signaling pathway.	Disulfiram	4-14	mitogen-activated protein kinase 8	Homo sapiens	118-121	
33792698-7	2021	The underlying mechanism of this process was explored, and DSF/Cu may mainly inhibit osteosarcoma by inducing apoptosis by activating the ROS/JNK pathway.	Disulfiram	59-62	mitogen-activated protein kinase 8	Homo sapiens	142-145	
32145587-8	2020	Additionally, activation of the c-Jun N-terminal kinase (JNK) signaling pathway was observed in DSF/Cu treated MM cells.	Disulfiram	96-99	mitogen-activated protein kinase 8	Homo sapiens	32-55	
32145587-8	2020	Additionally, activation of the c-Jun N-terminal kinase (JNK) signaling pathway was observed in DSF/Cu treated MM cells.	Disulfiram	96-99	mitogen-activated protein kinase 8	Homo sapiens	57-60	
21911303-0	2011	Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells.	Disulfiram	0-10	mitogen-activated protein kinase 8	Homo sapiens	36-39	
28518151-0	2017	Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kappaB and Nrf2.	Disulfiram	0-10	mitogen-activated protein kinase 8	Homo sapiens	119-122	
28518151-8	2017	Mechanistically, DS/Cu-induced cytotoxicity was closely associated with activation of the stress-related ROS-JNK pathway as well as simultaneous inactivation of the pro-survival Nrf2 and nuclear factor-kappaB pathways.	Disulfiram	17-19	mitogen-activated protein kinase 8	Homo sapiens	109-112	
24915933-0	2014	Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition.	Disulfiram	0-10	mitogen-activated protein kinase 8	Homo sapiens	59-62	
24915933-13	2014	DS/Cu induced phosphorylation of JNK and inhibits p65 expression as well as Nrf2 expression both in vitro and in vivo.	Disulfiram	0-2	mitogen-activated protein kinase 8	Homo sapiens	33-36	
24915933-18	2014	Moreover, ROS-related activation of JNK pathway and inhibition of NF-kappaB and Nrf2 may also contribute to the DS/Cu induced apoptosis.	Disulfiram	112-114	mitogen-activated protein kinase 8	Homo sapiens	36-39