PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31378764-0 2019 Disulfiram facilitates ataxin-3 nuclear translocation and potentiates the cytotoxicity in a cell model of SCA3. Disulfiram 0-10 ataxin 3 Homo sapiens 23-31 31378764-5 2019 Bearing this in mind, we treated cells expressing ataxin-3 with disulfiram to measure several pathogenic cascades of SCA3, including aggregate formation, soluble ataxin-3 expression and nuclear localization of ataxin-3 and the cytotoxicity, which assess the direct effect of disulfiram on SCA3 cell models. Disulfiram 64-74 ataxin 3 Homo sapiens 50-58 31378764-6 2019 To our knowledge, this is direct evidence that disulfiram elevated the nuclear localization of polyglutamine-expanded ataxin-3 and enhanced the cytotoxicity in a cell model of SCA3. Disulfiram 47-57 ataxin 3 Homo sapiens 118-126 31378764-8 2019 Our findings repurpose disulfiram as a modulator of ataxin-3 nuclear transport that aggravates the pathology of SCA3, which is a new target for disulfiram. Disulfiram 23-33 ataxin 3 Homo sapiens 52-60 31378764-8 2019 Our findings repurpose disulfiram as a modulator of ataxin-3 nuclear transport that aggravates the pathology of SCA3, which is a new target for disulfiram. Disulfiram 144-154 ataxin 3 Homo sapiens 52-60