PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35353287-6 2022 DSF/Cu shows stronger cytotoxicity to adenocarcinoma cell lines with higher malignant behavior, and valosin-containing protein (VCP) is its potential target. Disulfiram 0-3 valosin containing protein Homo sapiens 100-126 35353287-6 2022 DSF/Cu shows stronger cytotoxicity to adenocarcinoma cell lines with higher malignant behavior, and valosin-containing protein (VCP) is its potential target. Disulfiram 0-3 valosin containing protein Homo sapiens 128-131 33402676-5 2021 Recently, the anti-alcohol abuse drug disulfiram was found to target cancer through Npl4, a cofactor of p97, but the molecular mechanism remains elusive. Disulfiram 38-48 valosin containing protein Homo sapiens 104-107 33402676-8 2021 In vitro and cell-based assays showed that the disulfiram derivative bis-(diethyldithiocarbamate)-copper (CuET) can bypass the copper transporter system and inhibit the function of p97 in the cytoplasm by releasing cupric ions under oxidative conditions, which disrupt the zinc finger motifs of Npl4, locking the essential conformational switch of the complex. Disulfiram 47-57 valosin containing protein Homo sapiens 181-184 32085572-0 2020 Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway. Disulfiram 51-61 valosin containing protein Homo sapiens 30-33 30112292-0 2018 Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4. Disulfiram 0-10 valosin containing protein Homo sapiens 40-66 30112292-0 2018 Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4. Disulfiram 0-10 valosin containing protein Homo sapiens 67-70