PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28715099-1	1997	Ethanol and its metabolite acetaldehyde have been shown to stimulate immunoreactive beta-endorphin (IR-beta-EP) secretion from hypothalamic neurons in primary cultures.	Acetaldehyde	27-39	proopiomelanocortin	Homo sapiens	84-98	
2723981-6	1989	With ACTH therapy, ACE may resolve early postoperatively, but it tends to recur in most patients, continuing for as long as 3 years after the initial operation.	Acetaldehyde	19-22	proopiomelanocortin	Homo sapiens	5-9	
9161608-1	1997	Ethanol and its metabolite acetaldehyde have been shown to stimulate immunoreactive beta-endorphin (IR-beta-EP) secretion from hypothalamic neurons in primary cultures.	Acetaldehyde	27-39	proopiomelanocortin	Homo sapiens	84-98	
9161608-1	1997	Ethanol and its metabolite acetaldehyde have been shown to stimulate immunoreactive beta-endorphin (IR-beta-EP) secretion from hypothalamic neurons in primary cultures.	Acetaldehyde	27-39	proopiomelanocortin	Homo sapiens	103-110	
9161608-6	1997	Acetaldehyde stimulated IR-beta-EP secretion from this culture for a period of 48 hr, but the IR-beta-EP secretory response to acetaldehyde reduced gradually with time during the first 48-hr period and reached the basal level at 72 hr.	Acetaldehyde	0-12	proopiomelanocortin	Homo sapiens	27-34	
9161608-6	1997	Acetaldehyde stimulated IR-beta-EP secretion from this culture for a period of 48 hr, but the IR-beta-EP secretory response to acetaldehyde reduced gradually with time during the first 48-hr period and reached the basal level at 72 hr.	Acetaldehyde	127-139	proopiomelanocortin	Homo sapiens	97-104	
9161608-8	1997	However, reduced IR- beta-EP secretory response to acetaldehyde with time was associated with the time-dependent increase in cell death.	Acetaldehyde	51-63	proopiomelanocortin	Homo sapiens	21-28	
9161608-11	1997	These results suggest that (i) chronic treatment with ethanol desensitizes beta-EP-secreting neurons due to reduced cellular functions and (ii) chronic acetaldehyde reduces beta-EP neurotransmission due to cell death.	Acetaldehyde	152-164	proopiomelanocortin	Homo sapiens	173-180	
7625566-0	1995	Effect of ethanol, propanol, butanol, and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons: evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release.	Acetaldehyde	175-187	proopiomelanocortin	Homo sapiens	214-228	
7625566-1	1995	Previously, we have shown that low doses of ethanol (12.5-100 mM) and acetaldehyde (12.5-50 microM), but not salsolinol, enhanced immunoreactive beta-endorphin (IR-beta-EP) secretion from fetal hypothalamic neurons in primary culture.	Acetaldehyde	70-82	proopiomelanocortin	Homo sapiens	145-159	
7704432-0	1994	Comparison of the effects of alcohol and acetaldehyde on proopiomelanocortin mRNA levels and beta-endorphin secretion from hypothalamic neurons in primary cultures.	Acetaldehyde	41-53	proopiomelanocortin	Homo sapiens	57-76	
7704432-1	1994	The effects of acute and chronic treatments with ethanol and acute treatments with an ethanol metabolite, acetaldehyde, on proopiomelanocortin (POMC) mRNA expression were compared with those of these agents on the secretion of a POMC gene product, beta-endorphin (beta-EP) peptide.	Acetaldehyde	106-118	proopiomelanocortin	Homo sapiens	123-142	
7704432-1	1994	The effects of acute and chronic treatments with ethanol and acute treatments with an ethanol metabolite, acetaldehyde, on proopiomelanocortin (POMC) mRNA expression were compared with those of these agents on the secretion of a POMC gene product, beta-endorphin (beta-EP) peptide.	Acetaldehyde	106-118	proopiomelanocortin	Homo sapiens	144-148	
7704432-3	1994	Treatment of hypothalamic cells with 25-, 50-, and 100-mM doses of ethanol or 12.5 and 25 microM acetaldehyde for 3 h increased POMC mRNA levels.	Acetaldehyde	97-109	proopiomelanocortin	Homo sapiens	128-132	
7704432-5	1994	Acute treatments with ethanol and acetaldehyde also elevated IR-beta-EP secretion from the cultured neurons for a period of 12 h, and the IR-beta-EP secretory response developed desensitization after 24 h of ethanol incubation.	Acetaldehyde	34-46	proopiomelanocortin	Homo sapiens	64-71