PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33203037-10 2020 Interestingly, termination of the BPA exposure restores the Ppargamma promoter methylation and inflammatory profile of the 3T3L1 cells. bisphenol A 34-37 peroxisome proliferator activated receptor gamma Mus musculus 60-69 32623698-0 2021 Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARgamma. bisphenol A 12-23 peroxisome proliferator activated receptor gamma Mus musculus 140-149 32623698-8 2021 We revealed abnormal expression of lipid regulators in the liver and that inhibition of peroxisome proliferator-activated receptor gamma (PPARgamma) repressed hepatic lipid accumulation induced by gestational BPA exposure. bisphenol A 209-212 peroxisome proliferator activated receptor gamma Mus musculus 88-136 32623698-8 2021 We revealed abnormal expression of lipid regulators in the liver and that inhibition of peroxisome proliferator-activated receptor gamma (PPARgamma) repressed hepatic lipid accumulation induced by gestational BPA exposure. bisphenol A 209-212 peroxisome proliferator activated receptor gamma Mus musculus 138-147 32623698-12 2021 Dysregulation of the HNF1b/PPARgamma pathway may be involved in gestational BPA exposure-induced NAFLD in male offspring. bisphenol A 76-79 peroxisome proliferator activated receptor gamma Mus musculus 27-36 32012803-6 2020 BPA, BPS, and BPF increased lipid accumulation, protein expressions of adipogenic transcription factors (PPAR-gamma, C/EBP-alpha, and aP2), and reactive oxygen species (ROS) production in 3T3-L1 cells. bisphenol A 0-3 peroxisome proliferator activated receptor gamma Mus musculus 105-115 31778932-0 2020 Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and metabolism disturbance induced by bisphenol A and its replacement analog bisphenol S using in vitro macrophages and in vivo mouse models. bisphenol A 110-121 peroxisome proliferator activated receptor gamma Mus musculus 0-48 31778932-0 2020 Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and metabolism disturbance induced by bisphenol A and its replacement analog bisphenol S using in vitro macrophages and in vivo mouse models. bisphenol A 110-121 peroxisome proliferator activated receptor gamma Mus musculus 50-59 31778932-1 2020 Bisphenol A (BPA) and its replacement analog, bisphenol S (BPS), have been proposed as environmental obesogen to disrupt the lipid metabolism through regulating peroxisome proliferator-activated receptor gamma (PPARgamma) receptor. bisphenol A 0-11 peroxisome proliferator activated receptor gamma Mus musculus 161-209 31778932-1 2020 Bisphenol A (BPA) and its replacement analog, bisphenol S (BPS), have been proposed as environmental obesogen to disrupt the lipid metabolism through regulating peroxisome proliferator-activated receptor gamma (PPARgamma) receptor. bisphenol A 13-16 peroxisome proliferator activated receptor gamma Mus musculus 161-209 31778932-6 2020 The underlying mechanisms were further investigated using an in vivo mouse model, and the results confirmed the induction of PPARgamma and its respective target genes in mice following exposure to BPA or BPS. bisphenol A 197-200 peroxisome proliferator activated receptor gamma Mus musculus 125-134 30566610-4 2019 Network modeling prioritized main molecular targets of BPA, including Pparg, Hnf4a, Esr1, Srebf1, and Fasn as well as numerous less studied targets such as Cyp51 and long noncoding RNAs across tissues, Fa2h in hypothalamus, and Nfya in adipose tissue. bisphenol A 55-58 peroxisome proliferator activated receptor gamma Mus musculus 70-75 30777689-11 2019 Treatment with bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor gamma inhibitor, diminished PVAT formation but increased plaque size and macrophage infiltration. bisphenol A 15-26 peroxisome proliferator activated receptor gamma Mus musculus 47-95 26944108-8 2016 The pure estrogen receptor agonist diethylstilbestrol (DES) played an opposite action to that of BPA inhibiting PPARgamma activity in adipocytes, preventing cell differentiation, activating ERalpha in preadipocytes and inhibiting ERalpha and ERbeta regulation in adipocytes. bisphenol A 97-100 peroxisome proliferator activated receptor gamma Mus musculus 112-121 29305999-10 2018 However, pretreatment of HFD mice with bisphenol A diglycidyl ether (BADGE), the PPAR-gamma antagonist, reversed the acute lethal toxicity and bone marrow suppression of 5-Fu and accelerated the recovery of HSCs and platelets. bisphenol A 39-50 peroxisome proliferator activated receptor gamma Mus musculus 81-91 27273607-0 2016 Bisphenol S- and bisphenol A-induced adipogenesis of murine preadipocytes occurs through direct peroxisome proliferator-activated receptor gamma activation. bisphenol A 17-28 peroxisome proliferator activated receptor gamma Mus musculus 96-144 29410257-8 2018 In line with this, TMCP, DiDP, DiNP and DEGDB were able to activate PPARgamma in transient transfection assays, while previous studies demonstrated that BPA acts mainly through other nuclear receptors. bisphenol A 153-156 peroxisome proliferator activated receptor gamma Mus musculus 68-77 27273607-13 2016 Co-treatment of cells with the selective PPARgamma antagonist GW9662 inhibits BPS-, BPA-, ROSI- but not dexamethasone-dependent adipogenic differentiation. bisphenol A 84-87 peroxisome proliferator activated receptor gamma Mus musculus 41-50 27273607-14 2016 CONCLUSIONS: Both BPA and BPS can enhance 3T3-L1 adipocyte differentiation in a dose-dependent manner and require PPARgamma to induce adipogenesis. bisphenol A 18-21 peroxisome proliferator activated receptor gamma Mus musculus 114-123 26996129-5 2016 BPA induced the mRNA and protein expression levels of PPARgamma, C/EBPalpha and adiponectin, and the induction was inhibited by miR-21a-5p mimics transfection. bisphenol A 0-3 peroxisome proliferator activated receptor gamma Mus musculus 54-63 19922793-5 2010 In this study we demonstrate that the PPARgamma antagonist Bisphenol A diglycidyl ether (BADGE) and 2-Chloro-5-nitro-N-(4-pyridyl)benzamide (T0070907) reverse the inhibition of ES cell proliferation by PPARgamma agonists. bisphenol A 59-70 peroxisome proliferator activated receptor gamma Mus musculus 38-47 24338020-7 2014 PPARgamma antagonists (bisphenol A diglycidyl ether or GW9662) blunted the effects of rosiglitazone on PHD regulation. bisphenol A 23-34 peroxisome proliferator activated receptor gamma Mus musculus 0-9 20854792-10 2010 Furthermore, KD-induced hepatic PAI-1 expression was significantly suppressed by supplementation with bisphenol A diglycidyl ether, a PPARgamma antagonist, in both WT and PPARalpha-null mice. bisphenol A 102-113 peroxisome proliferator activated receptor gamma Mus musculus 134-143 19922793-5 2010 In this study we demonstrate that the PPARgamma antagonist Bisphenol A diglycidyl ether (BADGE) and 2-Chloro-5-nitro-N-(4-pyridyl)benzamide (T0070907) reverse the inhibition of ES cell proliferation by PPARgamma agonists. bisphenol A 59-70 peroxisome proliferator activated receptor gamma Mus musculus 202-211 16972249-3 2006 Control and insulin-deficient diabetic BALB/c mice were chronically treated with a peroxisomal proliferator-activated receptor gamma (PPARgamma) antagonist, bisphenol-A-diglycidyl ether (BADGE), to block adipocyte differentiation. bisphenol A 157-168 peroxisome proliferator activated receptor gamma Mus musculus 83-132 18643838-5 2009 The peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonist bisphenol A diglycidyl ether significantly abrogated the induction of mRNA, but not protein levels of ATGL by rosiglitazone in differentiated 3T3-L1 adipocytes. bisphenol A 76-87 peroxisome proliferator activated receptor gamma Mus musculus 4-52 18643838-5 2009 The peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonist bisphenol A diglycidyl ether significantly abrogated the induction of mRNA, but not protein levels of ATGL by rosiglitazone in differentiated 3T3-L1 adipocytes. bisphenol A 76-87 peroxisome proliferator activated receptor gamma Mus musculus 54-63 11991651-0 2002 Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7. bisphenol A 0-11 peroxisome proliferator activated receptor gamma Mus musculus 92-101 16844232-4 2006 In this study, we show that the PPARgamma antagonists, Bisphenol A diglycidyl ether (BADGE) and 2-chloro-5-nitro-N-(4-pyridyl)benzamide (T0070907), reverse the inhibition of EAE by the PPARgamma agonists, Ciglitazone and 15-Deoxy-Delta(12,14)-Prostaglandin J2, in C57BL/6 wild-type and PPARgamma+/- mice. bisphenol A 55-66 peroxisome proliferator activated receptor gamma Mus musculus 32-41 11991651-1 2002 Bisphenol A diglycidyl ether (BADGE) is a newly described peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist in adipogenic cells. bisphenol A 0-11 peroxisome proliferator activated receptor gamma Mus musculus 58-106 11991651-1 2002 Bisphenol A diglycidyl ether (BADGE) is a newly described peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist in adipogenic cells. bisphenol A 0-11 peroxisome proliferator activated receptor gamma Mus musculus 108-117