PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33460868-5 2021 After the QWOE evaluation, two potential estrogen receptor-related MOAs of BPA-induced testis dysfunction and learning-memory deficit were proposed. bisphenol A 75-78 estrogen receptor 1 Homo sapiens 41-58 34328988-1 2021 Complicated ligand-dependent signaling pathways of bisphenol A (BPA) and its analogues involve not only intranuclear estrogen receptor but also membrane receptor G protein-coupled estrogen receptor (GPER). bisphenol A 51-62 estrogen receptor 1 Homo sapiens 117-134 34328988-1 2021 Complicated ligand-dependent signaling pathways of bisphenol A (BPA) and its analogues involve not only intranuclear estrogen receptor but also membrane receptor G protein-coupled estrogen receptor (GPER). bisphenol A 64-67 estrogen receptor 1 Homo sapiens 117-134 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 184-187 estrogen receptor 1 Homo sapiens 66-83 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 184-187 estrogen receptor 1 Homo sapiens 85-92 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 184-187 estrogen receptor 1 Homo sapiens 94-100 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 184-187 estrogen receptor 1 Homo sapiens 268-274 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 230-233 estrogen receptor 1 Homo sapiens 66-83 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 230-233 estrogen receptor 1 Homo sapiens 85-92 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 230-233 estrogen receptor 1 Homo sapiens 94-100 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 230-233 estrogen receptor 1 Homo sapiens 259-266 34486460-6 2021 Additionally, our results considered that androgen receptor (AR), estrogen receptor (ERalpha, ERbeta), and NFKB1 gene expressions exhibited up-regulation in HPEpiC treated with 10-9 M BPA for 72 h. However, in HPrF, the identical BPA treatment could activate ERalpha, ERbeta, and NFKB1 gene expressions and down-regulated the expression of AR levels. bisphenol A 230-233 estrogen receptor 1 Homo sapiens 268-274 34438265-10 2021 Individuals with specific genotypes in ESR1/2, CAT, and eNOS might be more susceptible to the hypertensive effects of BPA. bisphenol A 118-121 estrogen receptor 1 Homo sapiens 39-45 34208714-8 2021 MD simulations showed that mitotane preserves the active conformation of ER-alpha more than both BPA and Bisphenol C, classifying it as an agonist. bisphenol A 97-100 estrogen receptor 1 Homo sapiens 73-81 34100320-4 2021 Here, we demonstrate that low dose BPA and fulvestrant (estrogen receptor antagonist) combination synergistically decrease proliferation, promote cell migration and mesenchymal transition, switching from E-cadherin to N-cadherin expression Hepg2 cells. bisphenol A 35-38 estrogen receptor 1 Homo sapiens 56-73 34602561-1 2021 Bisphenol A (BPA) has been shown to induce the activation of nuclear estrogen receptor alpha/beta (ERalpha/beta) in both in vitro and in vivo settings. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 69-97 34602561-1 2021 Bisphenol A (BPA) has been shown to induce the activation of nuclear estrogen receptor alpha/beta (ERalpha/beta) in both in vitro and in vivo settings. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 99-111 34602561-1 2021 Bisphenol A (BPA) has been shown to induce the activation of nuclear estrogen receptor alpha/beta (ERalpha/beta) in both in vitro and in vivo settings. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 69-97 34602561-1 2021 Bisphenol A (BPA) has been shown to induce the activation of nuclear estrogen receptor alpha/beta (ERalpha/beta) in both in vitro and in vivo settings. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 99-111 35489531-4 2022 BPA ability to induce oxidative stress through increased ROS production, altered activity of antioxidant enzymes, or accumulation of oxidation products of biomacromolecules is observed in a wide range of organisms - estrogen receptor-positive and -negative. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 216-233 35504317-7 2022 Besides estrogen receptor alpha and beta, BPA also uses non canonical membrane bound estrogen receptor and G-protein coupled estrogen receptor to confer its toxic effects. bisphenol A 42-45 estrogen receptor 1 Homo sapiens 8-31 35439536-8 2022 In summary, BPA may induce pyroptosis in neuroblastoma cells through NLRP3/caspase-1/GSDMD pathway, as mediated by ER; caspase-1-dependent pyroptosis may also contribute to BPA-induced apoptosis, an effect alleviated by EGCG. bisphenol A 12-15 estrogen receptor 1 Homo sapiens 115-117 35597549-5 2022 MAIN METHODS: Low metastatic ERalpha-positive human breast cancer cells (MCF-7) were exposed to nanomolar doses of BPA every 24 h (up to 200 days) to study the effect of repeated exposure on metastatic potential. bisphenol A 115-118 estrogen receptor 1 Homo sapiens 29-36 35597549-7 2022 KEY FINDINGS: A repeated exposure of low dose BPA induced stable epithelial-mesenchymal plasticity in MCF-7 cells to augment migration and invasion in the ERalpha-dependent pathway. bisphenol A 46-49 estrogen receptor 1 Homo sapiens 155-162 35597549-11 2022 SIGNIFICANCE: Repeated exposures of low dose BPA may induce metastatic aggression in ERalpha-positive breast cancer cells via PGC-1alpha-mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity. bisphenol A 45-48 estrogen receptor 1 Homo sapiens 85-92 35551214-4 2022 PCNA in D8 and D10 granulosa cells and ERalpha in D10 granulosa cells of follicles in BPA+Asta group were significantly higher. bisphenol A 86-89 estrogen receptor 1 Homo sapiens 39-46 35199272-6 2022 In this review, we analyzed certain researched effects of BPA, while focusing on its ability to alter the expression of various significant genes like GnRH, AdipoQ, ESR1, StAR, CYP11A1, CYP19A1, and many more involved in the pathways and endocrine regulation, whose disruption is commonly associated with the clinical manifestations of PCOS. bisphenol A 58-61 estrogen receptor 1 Homo sapiens 165-169 35263089-5 2022 mRNA and protein expression of ESR1 and ESR 2 were decreased by vincristine, while this decrease was reversed by DEHP and BPA. bisphenol A 122-125 estrogen receptor 1 Homo sapiens 31-35 35263089-6 2022 Both BPA and DEHP were able to interfere with the cytotoxic activity of vincristine against MCF-7 cells through ESR1 and ESR2. bisphenol A 5-8 estrogen receptor 1 Homo sapiens 112-116 35077665-2 2022 In the presented study, we have determined human estrogen receptor (hER)alpha agonist and antagonist activities with the validated OECD assay with the hERalpha-Hela9903 cell line for five different chemical classes of BPA and BPS analogs. bisphenol A 218-221 estrogen receptor 1 Homo sapiens 49-66 33836827-11 2021 Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4. bisphenol A 171-174 estrogen receptor 1 Homo sapiens 48-54 33836827-11 2021 Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4. bisphenol A 171-174 estrogen receptor 1 Homo sapiens 190-196 33558057-1 2021 OBJECTIVES: This study investigated the putative activation of estrogen receptor beta (ERbeta) and possible effects related on gene expression in oral mucosal cells in response to the endocrine disruptor Bisphenol A (BPA) and its analogues Bisphenol F (BPF) and Bisphenol S (BPS). bisphenol A 204-215 estrogen receptor 1 Homo sapiens 63-85 33558057-1 2021 OBJECTIVES: This study investigated the putative activation of estrogen receptor beta (ERbeta) and possible effects related on gene expression in oral mucosal cells in response to the endocrine disruptor Bisphenol A (BPA) and its analogues Bisphenol F (BPF) and Bisphenol S (BPS). bisphenol A 204-215 estrogen receptor 1 Homo sapiens 87-93 33558057-1 2021 OBJECTIVES: This study investigated the putative activation of estrogen receptor beta (ERbeta) and possible effects related on gene expression in oral mucosal cells in response to the endocrine disruptor Bisphenol A (BPA) and its analogues Bisphenol F (BPF) and Bisphenol S (BPS). bisphenol A 217-220 estrogen receptor 1 Homo sapiens 63-85 33558057-1 2021 OBJECTIVES: This study investigated the putative activation of estrogen receptor beta (ERbeta) and possible effects related on gene expression in oral mucosal cells in response to the endocrine disruptor Bisphenol A (BPA) and its analogues Bisphenol F (BPF) and Bisphenol S (BPS). bisphenol A 217-220 estrogen receptor 1 Homo sapiens 87-93 33558057-5 2021 RESULTS: The tested concentrations of BPA, BPF, BPS and E2 revealed distinct activation of ERbeta at all time periods, whereat 100 nM E2 induced the most pronounced activation. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 91-97 33683587-8 2021 The stimulatory effects of BPA on cancer cell proliferation and metastasis were reversed by treatment with an ERalpha inhibitor, but not by treatment with an ERbeta inhibitor. bisphenol A 27-30 estrogen receptor 1 Homo sapiens 110-117 33683587-9 2021 Together, these results suggest that BPA induces proliferation and metastasis of ovarian cancer cells through ERalpha signaling pathways. bisphenol A 37-40 estrogen receptor 1 Homo sapiens 110-117 33431410-2 2021 While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are unclear. bisphenol A 6-9 estrogen receptor 1 Homo sapiens 52-69 33431410-2 2021 While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are unclear. bisphenol A 6-9 estrogen receptor 1 Homo sapiens 71-73 33022573-0 2021 BPA modulates the WDR5/TET2 complex to regulate ERbeta expression in eutopic endometrium and drives the development of endometriosis. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 48-54 33022573-3 2021 This study aimed to explore the effects of bisphenol A (BPA) exposure on EM development from the perspective of the regulation of ERbeta expression in eutopic endometrium via the H3K4me3-related epigenetic pathway. bisphenol A 43-54 estrogen receptor 1 Homo sapiens 130-136 33022573-3 2021 This study aimed to explore the effects of bisphenol A (BPA) exposure on EM development from the perspective of the regulation of ERbeta expression in eutopic endometrium via the H3K4me3-related epigenetic pathway. bisphenol A 56-59 estrogen receptor 1 Homo sapiens 130-136 33022573-13 2021 In conclusion, our study suggests that BPA exposure promotes EM development by upregulating ERbeta expression in eutopic endometrium via the WDR5/TET2-mediated epigenetic pathway. bisphenol A 39-42 estrogen receptor 1 Homo sapiens 92-98 33181973-5 2020 Bisphenol A (BPA) is an endocrine disruptor compound (EDC) widely used in the manufacture of polycarbonates, and it has affinity for the estrogen receptor (ER). bisphenol A 0-11 estrogen receptor 1 Homo sapiens 137-154 33181973-5 2020 Bisphenol A (BPA) is an endocrine disruptor compound (EDC) widely used in the manufacture of polycarbonates, and it has affinity for the estrogen receptor (ER). bisphenol A 0-11 estrogen receptor 1 Homo sapiens 156-158 33181973-5 2020 Bisphenol A (BPA) is an endocrine disruptor compound (EDC) widely used in the manufacture of polycarbonates, and it has affinity for the estrogen receptor (ER). bisphenol A 13-16 estrogen receptor 1 Homo sapiens 137-154 33181973-5 2020 Bisphenol A (BPA) is an endocrine disruptor compound (EDC) widely used in the manufacture of polycarbonates, and it has affinity for the estrogen receptor (ER). bisphenol A 13-16 estrogen receptor 1 Homo sapiens 156-158 33181973-16 2020 MMP-14) were importantly increased by BPA and BPS in ER-positive breast cancer cells. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 53-55 33066495-4 2020 Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 171-178 33066495-4 2020 Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 183-189 33066495-4 2020 Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 171-178 33066495-4 2020 Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 183-189 32559890-6 2020 Using Western blotting and specific pharmacological inhibitors in the acute study, we have shown that direct BPA"s action in EA.hy926 cells involves activation of estrogen receptor (ER), phosphorylation of protein kinase B (PKB/Akt) and endothelial nitric oxide synthase (eNOS)-mediated production of NO. bisphenol A 109-112 estrogen receptor 1 Homo sapiens 163-180 32559890-6 2020 Using Western blotting and specific pharmacological inhibitors in the acute study, we have shown that direct BPA"s action in EA.hy926 cells involves activation of estrogen receptor (ER), phosphorylation of protein kinase B (PKB/Akt) and endothelial nitric oxide synthase (eNOS)-mediated production of NO. bisphenol A 109-112 estrogen receptor 1 Homo sapiens 182-184 32559890-7 2020 Collectively, these data indicate that BPA induces functional and molecular changes in EA.hy926 cells associated with the promotion of endothelial integrity through activation of the ER/Akt/eNOS pathway. bisphenol A 39-42 estrogen receptor 1 Homo sapiens 183-185 32334263-7 2020 Intriguingly, we observed for the first time that BPA-induced effects were associated to a sex specific modulation of ERalpha and ERbeta in human PBMC. bisphenol A 50-53 estrogen receptor 1 Homo sapiens 118-125 32334263-7 2020 Intriguingly, we observed for the first time that BPA-induced effects were associated to a sex specific modulation of ERalpha and ERbeta in human PBMC. bisphenol A 50-53 estrogen receptor 1 Homo sapiens 130-136 32348927-11 2020 In conclusion, exposure to high levels BPA may be associated with NSCLC and the relationship may be modified by genetic polymorphism in ESR1. bisphenol A 39-42 estrogen receptor 1 Homo sapiens 136-140 32753632-8 2020 These findings suggested that COX-2 and L-PGDS could mediate low-dose BPA-induced prostatic hyperplasia through pathways involved in cell proliferation and apoptosis, which might be related to the functions of ERalpha and AR. bisphenol A 70-73 estrogen receptor 1 Homo sapiens 210-217 32387340-3 2020 We applied next generation sequencing (NGS) with the estrogen receptor alpha (ERalpha) positive human breast cancer cell line MCF-7 treated with 17-beta-estradiol (E2), bisphenol A (BPA), bisphenol B (BPB), bisphenol Z (BPZ) and tetramethyl bisphenol A (4MeBPA). bisphenol A 169-180 estrogen receptor 1 Homo sapiens 53-76 32387340-3 2020 We applied next generation sequencing (NGS) with the estrogen receptor alpha (ERalpha) positive human breast cancer cell line MCF-7 treated with 17-beta-estradiol (E2), bisphenol A (BPA), bisphenol B (BPB), bisphenol Z (BPZ) and tetramethyl bisphenol A (4MeBPA). bisphenol A 182-185 estrogen receptor 1 Homo sapiens 78-85 32387340-7 2020 We further confirmed the binding, activation and proliferative effect of BPA, BPB, BPZ, and 4MeBPA on ERalpha. bisphenol A 73-76 estrogen receptor 1 Homo sapiens 102-109 32610363-6 2021 In addition, we found that BPA at environmentally relevant concentration (10-7 M) reduced Cx43 expression and GJIC in GCs through estrogen receptor and mitogen-activated protein kinase (MAPK) pathways. bisphenol A 27-30 estrogen receptor 1 Homo sapiens 130-147 32565931-6 2020 The pooled analysis indicated that the most significant pathway was G1/S checkpoint regulation, and the cyclin and cell cycle regulation pathway for BPA-associated ER-positive cancer. bisphenol A 149-152 estrogen receptor 1 Homo sapiens 164-166 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 49-66 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 68-70 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 123-129 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 111-114 estrogen receptor 1 Homo sapiens 68-70 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 111-114 estrogen receptor 1 Homo sapiens 123-129 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 111-114 estrogen receptor 1 Homo sapiens 68-70 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 111-114 estrogen receptor 1 Homo sapiens 123-129 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 111-114 estrogen receptor 1 Homo sapiens 68-70 32547491-2 2020 These endocrine-disrupting effects of BPA at the estrogen receptor (ER) occur despite the very low affinity of BPA for the ERbeta, which is 10,000 times lower than that of 17-beta estradiol, and despite the European regulatory authorities stating that BPA is safe, at usual exposure concentrations, the use of BPA in baby drink bottles was banned in 2011. bisphenol A 111-114 estrogen receptor 1 Homo sapiens 123-129 31995776-7 2020 Our results showed that BPA, BPS, and BPF (BPs) have estrogen agonist and androgen antagonist activities and decrease the ERalpha protein level. bisphenol A 24-27 estrogen receptor 1 Homo sapiens 122-129 31995776-7 2020 Our results showed that BPA, BPS, and BPF (BPs) have estrogen agonist and androgen antagonist activities and decrease the ERalpha protein level. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 122-129 32092037-11 2020 BPA reduced MAPK3/1 phosphorylation and ESR1 and ESR2 gene expression, effects that were not observed with BPS. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 40-44 32105160-12 2020 RESULTS: We measured higher proliferation in ER+ breast cancer cells treated with BPA or its replacement, BPS, accompanied by an ERalpha-dependent decrease in genomic DNA hydroxymethylation. bisphenol A 82-85 estrogen receptor 1 Homo sapiens 129-136 32105160-14 2020 On the other hand, we observed that TET2 was negatively regulated by the activation of ERalpha (dimerized and phosphorylated), which was also induced by BPA/BPS binding. bisphenol A 153-156 estrogen receptor 1 Homo sapiens 87-94 32105160-16 2020 CONCLUSIONS: We identified a new feedback circuit of ERalpha activation-DNMT-TET2-DNA hydroxymethylation in ER+ breast cancer cells and uncovered a pivotal role of TET2-mediated DNA hydroxymethylation in modulating BPA/BPS-stimulated proliferation. bisphenol A 215-218 estrogen receptor 1 Homo sapiens 53-60 31876196-9 2020 After BPA-exposure, expression of ERalpha increased significantly in pSS patients, while that of ERbeta remained unchanged. bisphenol A 6-9 estrogen receptor 1 Homo sapiens 34-41 31876196-11 2020 BPA increased HLA-DR on moDCs of pSS patients via ERalpha, and promoted the secretion of IL6 and IL12. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 50-57 31876196-12 2020 When co-cultured with BPA-treated moDCs, cytokines (IFN-gamma, IL4, IL17, IL10) and transcription factors (T-bet, Gata3, RoR-gammat, Foxp3) of CD4+ T cells showed imbalance of Th1/Th2/Th17/Treg polarization, with Th1 and Th17 dominating.Conclusions: BPA altered the function of moDCs through ERalpha, including antigen capture, secretion of inflammatory factors, and ability to stimulate T cells, as well as accelerated the progression and further deterioration of pSS. bisphenol A 22-25 estrogen receptor 1 Homo sapiens 292-299 31926947-0 2020 Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor alpha-dependent manner in perinatal brain. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 65-88 31926947-0 2020 Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor alpha-dependent manner in perinatal brain. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 65-88 31926947-3 2020 The present study utilizes a progesterone receptor (PR) expression bioassay to assess the estrogen receptor alpha (ERalpha)-dependent effects of BPA in fetal rodent brain following maternal exposure. bisphenol A 145-148 estrogen receptor 1 Homo sapiens 90-113 31926947-3 2020 The present study utilizes a progesterone receptor (PR) expression bioassay to assess the estrogen receptor alpha (ERalpha)-dependent effects of BPA in fetal rodent brain following maternal exposure. bisphenol A 145-148 estrogen receptor 1 Homo sapiens 115-122 31926947-7 2020 However, pretreatment with the ER antagonist, ICI 182,780 from P1-4 significantly attenuated the effects of BPA on PR expression, indicating an ERalpha-dependent mechanism. bisphenol A 108-111 estrogen receptor 1 Homo sapiens 144-151 31681507-0 2019 Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells. bisphenol A 24-35 estrogen receptor 1 Homo sapiens 47-70 31681507-7 2019 Laser confocal microscopy was performed to determine the cytolocalization of p53 and ERalpha upon treatment with BPA. bisphenol A 113-116 estrogen receptor 1 Homo sapiens 85-92 31614463-3 2019 Here we demonstrated that 17beta-estradiol (E2), as well as xenoestrogen bisphenol A and ERalpha agonist propyl pyrazole triol, led to HSF1 phosphorylation on S326 in ERalpha positive but not in ERalpha-negative mammary breast cancer cells. bisphenol A 60-84 estrogen receptor 1 Homo sapiens 167-174 31614463-3 2019 Here we demonstrated that 17beta-estradiol (E2), as well as xenoestrogen bisphenol A and ERalpha agonist propyl pyrazole triol, led to HSF1 phosphorylation on S326 in ERalpha positive but not in ERalpha-negative mammary breast cancer cells. bisphenol A 60-84 estrogen receptor 1 Homo sapiens 167-174 31601247-0 2019 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. bisphenol A 86-96 estrogen receptor 1 Homo sapiens 47-64 31601247-6 2019 RESULTS: The three bisphenols caused ER-dependent increased proliferation and migration of MCF-7 but not MDA-MB-231 cells, with BPS being 10 times less potent than BPA and BPF. bisphenol A 19-29 estrogen receptor 1 Homo sapiens 37-39 31601247-6 2019 RESULTS: The three bisphenols caused ER-dependent increased proliferation and migration of MCF-7 but not MDA-MB-231 cells, with BPS being 10 times less potent than BPA and BPF. bisphenol A 164-167 estrogen receptor 1 Homo sapiens 37-39 31601247-7 2019 Although they have similar chemical structures, the three bisphenols induced differential DNA methylation alterations at several genomic clusters of or single CpG sites, with the majority of these being ER-dependent. bisphenol A 58-68 estrogen receptor 1 Homo sapiens 203-205 31601247-9 2019 No pathways were enriched for BPF while BPA- and BPS-induced methylome alterations were enriched in focal adhesion, cGMP-PKG, and cancer pathways, which were also dysregulated in methylome-wide alterations comparing ER-positive breast cancer samples to adjacent normal tissues. bisphenol A 40-43 estrogen receptor 1 Homo sapiens 216-218 31278978-4 2019 At 50 nM, BPA induced ERVW-1, ERVFRD-1 and the corresponding syncytin proteins, ERV3-1, PPARgamma, ERalpha and ERbeta expression, increased beta-hCG secretion and BeWo cells fusion, thus promoting the syncytiotrophoblast phenotype. bisphenol A 10-13 estrogen receptor 1 Homo sapiens 99-106 31278978-4 2019 At 50 nM, BPA induced ERVW-1, ERVFRD-1 and the corresponding syncytin proteins, ERV3-1, PPARgamma, ERalpha and ERbeta expression, increased beta-hCG secretion and BeWo cells fusion, thus promoting the syncytiotrophoblast phenotype. bisphenol A 10-13 estrogen receptor 1 Homo sapiens 111-117 31551929-8 2019 BPA exposure activated ERalpha and ERbeta in the spleen 24 h after infection and phosphorylated ERalpha and ERbeta during myocarditis, but decreased ERalpha and increased ERbeta mRNA in the heart as measured by qRT-PCR. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 23-30 31551929-8 2019 BPA exposure activated ERalpha and ERbeta in the spleen 24 h after infection and phosphorylated ERalpha and ERbeta during myocarditis, but decreased ERalpha and increased ERbeta mRNA in the heart as measured by qRT-PCR. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 96-103 31551929-8 2019 BPA exposure activated ERalpha and ERbeta in the spleen 24 h after infection and phosphorylated ERalpha and ERbeta during myocarditis, but decreased ERalpha and increased ERbeta mRNA in the heart as measured by qRT-PCR. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 96-103 30980863-11 2019 Although BPA acts as an estrogen receptor (ER) agonist, mitotic defects caused by BPA occurred in an ER-independent manner. bisphenol A 9-12 estrogen receptor 1 Homo sapiens 24-41 30980863-11 2019 Although BPA acts as an estrogen receptor (ER) agonist, mitotic defects caused by BPA occurred in an ER-independent manner. bisphenol A 9-12 estrogen receptor 1 Homo sapiens 43-45 30980863-11 2019 Although BPA acts as an estrogen receptor (ER) agonist, mitotic defects caused by BPA occurred in an ER-independent manner. bisphenol A 82-85 estrogen receptor 1 Homo sapiens 101-103 31463084-2 2019 We have previously shown in vitro that exposures to 17beta-estradiol (E2) and the endocrine disrupting chemical bisphenol A, at concentrations relevant to human exposure, cause an elevation of estrogen receptor alpha (Esr1) mRNA in primary cultures of fetal mouse prostate mesenchymal cells; a similar result was observed in the fetal rat urogenital sinus. bisphenol A 112-123 estrogen receptor 1 Homo sapiens 193-216 31463084-2 2019 We have previously shown in vitro that exposures to 17beta-estradiol (E2) and the endocrine disrupting chemical bisphenol A, at concentrations relevant to human exposure, cause an elevation of estrogen receptor alpha (Esr1) mRNA in primary cultures of fetal mouse prostate mesenchymal cells; a similar result was observed in the fetal rat urogenital sinus. bisphenol A 112-123 estrogen receptor 1 Homo sapiens 218-222 31230753-5 2019 BPA at 1-100 muM also activate ERE-Luc reporter expression in the transfected cells, which was through the ERalpha, but not ERbeta or GPR30 binding. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 107-114 31195007-5 2019 The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERalpha, ERbeta, ERRgamma, and GR, with IC50 values of 3.3-73 nM. bisphenol A 34-37 estrogen receptor 1 Homo sapiens 162-169 31289329-3 2019 Here, we screen 127 BPA-related compounds by competitive-binding assay using [3H]oestradiol and find that 20 compounds bind to ERalpha with high affinity. bisphenol A 20-23 estrogen receptor 1 Homo sapiens 127-134 30951782-3 2019 It has been well published that BPA along with its analogs bind and activate estrogen receptors (ER) alpha and beta, estrogen related receptor (ERR) gamma and pregnan X receptor (PXR). bisphenol A 32-35 estrogen receptor 1 Homo sapiens 77-106 30831350-0 2019 Computational insights on agonist and antagonist mechanisms of estrogen receptor alpha induced by bisphenol A analogues. bisphenol A 98-109 estrogen receptor 1 Homo sapiens 63-86 30831350-4 2019 Thus, we adopted computational models combining molecular dynamics simulations and binding free energy calculations to explore the underlying molecular basis of BPA analogues binding to estrogen receptor alpha (ERalpha). bisphenol A 161-164 estrogen receptor 1 Homo sapiens 186-209 30831350-4 2019 Thus, we adopted computational models combining molecular dynamics simulations and binding free energy calculations to explore the underlying molecular basis of BPA analogues binding to estrogen receptor alpha (ERalpha). bisphenol A 161-164 estrogen receptor 1 Homo sapiens 211-218 30831350-7 2019 Moreover, antagonists of BPA analogues could indirectly induce the structural reposition of key helix 12 and produce an antagonistic conformation of ERalpha. bisphenol A 25-28 estrogen receptor 1 Homo sapiens 149-156 30851587-3 2019 In this study, we demonstrated the effects of bisphenol A (BPA), benzyl butyl phthalate (BBP), and di(2-ethylhexyl) phthalate (DEHP) on estrogen receptor alpha (ERalpha) expression under normoxia and hypoxia. bisphenol A 46-57 estrogen receptor 1 Homo sapiens 136-159 30851587-3 2019 In this study, we demonstrated the effects of bisphenol A (BPA), benzyl butyl phthalate (BBP), and di(2-ethylhexyl) phthalate (DEHP) on estrogen receptor alpha (ERalpha) expression under normoxia and hypoxia. bisphenol A 46-57 estrogen receptor 1 Homo sapiens 161-168 30851587-3 2019 In this study, we demonstrated the effects of bisphenol A (BPA), benzyl butyl phthalate (BBP), and di(2-ethylhexyl) phthalate (DEHP) on estrogen receptor alpha (ERalpha) expression under normoxia and hypoxia. bisphenol A 59-62 estrogen receptor 1 Homo sapiens 136-159 30851587-5 2019 Compared to the 100% activity induced by 1 nM 17-beta-estradiol (positive control), BPA and BBP exhibited 50% ERalpha activation at concentrations of 1.31 muM and 4.8 muM, respectively. bisphenol A 84-87 estrogen receptor 1 Homo sapiens 110-117 30677511-0 2019 Involvement of estrogen receptor and GPER in bisphenol A induced proliferation of vascular smooth muscle cells. bisphenol A 45-56 estrogen receptor 1 Homo sapiens 15-32 30677511-9 2019 Blocking the functions of ERalpha and GPER by their specific inhibitors can attenuate the BPA induced proliferation of VSMCs and expression of Ang II. bisphenol A 90-93 estrogen receptor 1 Homo sapiens 26-33 30677511-10 2019 Consistently, BPA induced expression of TNFalpha and IL-6 was also attenuated by inhibitors of ERalpha and GPER. bisphenol A 14-17 estrogen receptor 1 Homo sapiens 95-102 30677511-13 2019 Collectively, our present study suggested that BPA can trigger the proliferation of VSMCs via both ERalpha and GPER dependent manners. bisphenol A 47-50 estrogen receptor 1 Homo sapiens 99-106 30187510-0 2019 Effects of bisphenol A on gap junctions in HaCaT cells as mediated by the estrogen receptor pathway. bisphenol A 11-22 estrogen receptor 1 Homo sapiens 74-91 30187510-8 2019 Estrogen receptor (ER) antagonist ICI 182 780 at 5 nm partially blocked the above effects of BPA indicating involvement of the ER pathway with BPA exposure. bisphenol A 93-96 estrogen receptor 1 Homo sapiens 0-17 30187510-8 2019 Estrogen receptor (ER) antagonist ICI 182 780 at 5 nm partially blocked the above effects of BPA indicating involvement of the ER pathway with BPA exposure. bisphenol A 93-96 estrogen receptor 1 Homo sapiens 19-21 30187510-8 2019 Estrogen receptor (ER) antagonist ICI 182 780 at 5 nm partially blocked the above effects of BPA indicating involvement of the ER pathway with BPA exposure. bisphenol A 93-96 estrogen receptor 1 Homo sapiens 127-129 30187510-8 2019 Estrogen receptor (ER) antagonist ICI 182 780 at 5 nm partially blocked the above effects of BPA indicating involvement of the ER pathway with BPA exposure. bisphenol A 143-146 estrogen receptor 1 Homo sapiens 0-17 30187510-8 2019 Estrogen receptor (ER) antagonist ICI 182 780 at 5 nm partially blocked the above effects of BPA indicating involvement of the ER pathway with BPA exposure. bisphenol A 143-146 estrogen receptor 1 Homo sapiens 19-21 30187510-8 2019 Estrogen receptor (ER) antagonist ICI 182 780 at 5 nm partially blocked the above effects of BPA indicating involvement of the ER pathway with BPA exposure. bisphenol A 143-146 estrogen receptor 1 Homo sapiens 127-129 30187510-12 2019 In conclusion, our results indicate that BPA can promote human skin cell proliferation, inhibit skin cell GJIC function but not formation and downregulate Cx26 mRNA levels partially through the ER pathway. bisphenol A 41-44 estrogen receptor 1 Homo sapiens 194-196 30582956-2 2019 In this study, we characterized the agonistic and/or antagonistic activities of BPA and eight its analogues against human estrogen receptors (ERalpha/beta), androgen receptor (AR), glucocorticoid receptor (GR), pregnane X receptor (PXR), and constitutive androstane receptor (CAR). bisphenol A 80-83 estrogen receptor 1 Homo sapiens 142-149 30848227-3 2019 BPA exerts endocrine disruptor action due to its weak binding affinity for the estrogen receptors ERalpha and ERbeta. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 98-105 30848227-3 2019 BPA exerts endocrine disruptor action due to its weak binding affinity for the estrogen receptors ERalpha and ERbeta. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 110-116 30580332-9 2019 BPA resulted in an increase in the gene expression of Esr1 in the mPFC of females on both P10 and P90. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 54-58 30467747-4 2019 In the current study, low concentrations of BPA reduced TAM-induced cytotoxicity of MCF-7 cells, which was proved by the suppression of cell apoptosis, transition of cell cycle from G1 to S phase, and upregulation of cyclin D1 and ERalpha. bisphenol A 44-47 estrogen receptor 1 Homo sapiens 231-238 29643374-0 2019 BPA exposure is associated with non-monotonic alteration in ESR1 promoter methylation in peripheral blood of men and shorter relative telomere length in peripheral blood of women. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 60-64 29643374-1 2019 The aim of this study was to evaluate the potential association of urinary Bisphenol A (BPA) levels with estrogen receptor alpha (ESR1) promoter % methylation and relative telomere length in a sample of 482 participants. bisphenol A 75-86 estrogen receptor 1 Homo sapiens 130-134 29643374-1 2019 The aim of this study was to evaluate the potential association of urinary Bisphenol A (BPA) levels with estrogen receptor alpha (ESR1) promoter % methylation and relative telomere length in a sample of 482 participants. bisphenol A 88-91 estrogen receptor 1 Homo sapiens 130-134 29643374-5 2019 There was a potentially non-monotonic relationship between adjusted urinary BPA concentrations and ESR1 promoter % methylation in men. bisphenol A 76-79 estrogen receptor 1 Homo sapiens 99-103 30195206-1 2018 Bisphenol F (BPF), one of the alternatives to bisphenol A (BPA), can induce proliferation through the nuclear estrogen receptor ERalpha (estrogen receptor alpha) pathway in human breast cancer MCF-7 cells. bisphenol A 46-57 estrogen receptor 1 Homo sapiens 137-160 30195206-1 2018 Bisphenol F (BPF), one of the alternatives to bisphenol A (BPA), can induce proliferation through the nuclear estrogen receptor ERalpha (estrogen receptor alpha) pathway in human breast cancer MCF-7 cells. bisphenol A 59-62 estrogen receptor 1 Homo sapiens 128-135 30195206-1 2018 Bisphenol F (BPF), one of the alternatives to bisphenol A (BPA), can induce proliferation through the nuclear estrogen receptor ERalpha (estrogen receptor alpha) pathway in human breast cancer MCF-7 cells. bisphenol A 59-62 estrogen receptor 1 Homo sapiens 137-160 29428396-3 2018 BPA has a weak affinity for ERalpha/beta but interaction with extranuclearly located pathways activated by estrogens such as ERRgamma and GPER reveals how BPA can act at low doses. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 28-40 29428396-3 2018 BPA has a weak affinity for ERalpha/beta but interaction with extranuclearly located pathways activated by estrogens such as ERRgamma and GPER reveals how BPA can act at low doses. bisphenol A 155-158 estrogen receptor 1 Homo sapiens 28-40 29964091-8 2018 These findings support that BPA induces oxidative stress and activates inflammatory signals in cultured ESCs via ER-alpha. bisphenol A 28-31 estrogen receptor 1 Homo sapiens 113-121 30206973-6 2018 We found that: (1) BPA increased StAR protein levels in a dose-dependent manner; (2) both estrogen receptor alpha (ERalpha)- and ERbeta-specific agonists mimicked while the ER antagonist ICI abrogated the stimulatory effects of BPA on StAR protein levels; and (3) BPA did not alter StAR messenger RNA, 37kDa preprotein or protein half-life. bisphenol A 19-22 estrogen receptor 1 Homo sapiens 90-113 30206973-6 2018 We found that: (1) BPA increased StAR protein levels in a dose-dependent manner; (2) both estrogen receptor alpha (ERalpha)- and ERbeta-specific agonists mimicked while the ER antagonist ICI abrogated the stimulatory effects of BPA on StAR protein levels; and (3) BPA did not alter StAR messenger RNA, 37kDa preprotein or protein half-life. bisphenol A 19-22 estrogen receptor 1 Homo sapiens 115-122 29737547-0 2018 Bisphenol A (BPA) binding on full-length architectures of estrogen receptor. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 58-75 29737547-0 2018 Bisphenol A (BPA) binding on full-length architectures of estrogen receptor. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 58-75 29737547-1 2018 Previous research has shown that the major toxicity mechanism for many environment chemicals is binding with estrogen receptor (ER) and blocking endogenous estrogen access, including bisphenol A (BPA). bisphenol A 183-194 estrogen receptor 1 Homo sapiens 109-126 29737547-1 2018 Previous research has shown that the major toxicity mechanism for many environment chemicals is binding with estrogen receptor (ER) and blocking endogenous estrogen access, including bisphenol A (BPA). bisphenol A 196-199 estrogen receptor 1 Homo sapiens 109-126 29737547-1 2018 Previous research has shown that the major toxicity mechanism for many environment chemicals is binding with estrogen receptor (ER) and blocking endogenous estrogen access, including bisphenol A (BPA). bisphenol A 196-199 estrogen receptor 1 Homo sapiens 128-130 29737547-2 2018 However, the molecular level understanding the global consequence of BPA binding on the full-length architectures of ER is largely unknown, which is a necessary stage to evaluate estrogen-like toxicity of BPA. bisphenol A 69-72 estrogen receptor 1 Homo sapiens 117-119 29737547-3 2018 In the present work, the consequence of BPA on full-length architectures of ER was firstly modeled based on molecular dynamics, focusing on the cross communication between multi-domains including ligand binding domain (LBD) and DNA binding domain (DBD). bisphenol A 40-43 estrogen receptor 1 Homo sapiens 76-78 29737547-7 2018 It might provide detailed insight into the knowledge about the structural characteristics of ER and its role in gene regulation, which eventually helped us evaluate the estrogen-like toxicity upon BPA binding with full-length ER. bisphenol A 197-200 estrogen receptor 1 Homo sapiens 93-95 29737547-7 2018 It might provide detailed insight into the knowledge about the structural characteristics of ER and its role in gene regulation, which eventually helped us evaluate the estrogen-like toxicity upon BPA binding with full-length ER. bisphenol A 197-200 estrogen receptor 1 Homo sapiens 226-228 29961922-0 2018 Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study. bisphenol A 100-111 estrogen receptor 1 Homo sapiens 72-76 29961922-3 2018 Considering that free BPA binds to estrogen receptors causing harmful effects to health, the present in vivo study aimed to evaluate the association between genetic polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted BPA levels in orthodontic patients. bisphenol A 22-25 estrogen receptor 1 Homo sapiens 217-221 29961922-3 2018 Considering that free BPA binds to estrogen receptors causing harmful effects to health, the present in vivo study aimed to evaluate the association between genetic polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted BPA levels in orthodontic patients. bisphenol A 245-248 estrogen receptor 1 Homo sapiens 217-221 29945225-10 2018 The metabolites promoted significant ER-dependent transcriptional activity of an ERE-luciferase reporter construct at 10 and 20 microM for 2OH and 10 microM for 3OH. bisphenol A 139-142 estrogen receptor 1 Homo sapiens 37-39 29808400-2 2018 The endocrine system interfered by BPA has been inventoried as it has the same function as the natural hormone 17beta-estradiol and binds mainly to the estrogen receptor (ER) to exhibit estrogenic activities. bisphenol A 35-38 estrogen receptor 1 Homo sapiens 152-169 29808400-2 2018 The endocrine system interfered by BPA has been inventoried as it has the same function as the natural hormone 17beta-estradiol and binds mainly to the estrogen receptor (ER) to exhibit estrogenic activities. bisphenol A 35-38 estrogen receptor 1 Homo sapiens 171-173 29970676-0 2018 The effect of TGF-beta signaling on regulating proliferation of uterine leiomyoma cell via ERalpha signaling activated by bisphenol A, octylphenol and nonylphenol in vitro. bisphenol A 122-133 estrogen receptor 1 Homo sapiens 91-98 29152682-1 2018 The binding interactions of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to human estrogen receptor alpha ligand binding domain (hERalpha-LBD) was investigated using a combined in vitro and in silico approach. bisphenol A 28-39 estrogen receptor 1 Homo sapiens 106-129 29152682-1 2018 The binding interactions of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to human estrogen receptor alpha ligand binding domain (hERalpha-LBD) was investigated using a combined in vitro and in silico approach. bisphenol A 41-44 estrogen receptor 1 Homo sapiens 106-129 29330934-0 2018 Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. bisphenol A 71-82 estrogen receptor 1 Homo sapiens 97-114 29330934-4 2018 In this study, we intended to reveal the effects of melatonin on BPA-induced proliferation of estrogen receptor-positive BC cells. bisphenol A 65-68 estrogen receptor 1 Homo sapiens 94-111 29389661-7 2018 RESULTS: We demonstrated that BPA and BPAF have agonistic activity for both ERalpha and ERbeta, but BPS has ERalpha-selective specificity. bisphenol A 30-33 estrogen receptor 1 Homo sapiens 76-83 29389661-11 2018 In addition, the binding surface of coregulator interactions on ERalpha was characterized for the BPA, BPAF, and BPS complexes. bisphenol A 98-101 estrogen receptor 1 Homo sapiens 64-71 28709040-0 2017 Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-alpha pathway. bisphenol A 22-33 estrogen receptor 1 Homo sapiens 126-149 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 130-133 estrogen receptor 1 Homo sapiens 39-62 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 130-133 estrogen receptor 1 Homo sapiens 64-71 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 130-133 estrogen receptor 1 Homo sapiens 102-109 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 130-133 estrogen receptor 1 Homo sapiens 102-109 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 220-223 estrogen receptor 1 Homo sapiens 39-62 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 220-223 estrogen receptor 1 Homo sapiens 64-71 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 220-223 estrogen receptor 1 Homo sapiens 102-109 28709040-6 2017 Importantly, all of these effects were estrogen receptor alpha (ERalpha) dependent, as siRNA-mediated ERalpha silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERalpha-conducted signaling in BPA-induced biological effects. bisphenol A 220-223 estrogen receptor 1 Homo sapiens 102-109 28591870-0 2017 Editor"s Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells. bisphenol A 52-63 estrogen receptor 1 Homo sapiens 86-109 28591870-9 2017 The comparison of transcriptome profile alterations resulting from BPA alternatives with an ERalpha gene expression biomarker further indicates that all BPA alternatives act as ERalpha agonists in MCF-7 cells. bisphenol A 153-156 estrogen receptor 1 Homo sapiens 177-184 28704378-4 2017 As expected, BPA induced 70-80% of the estrogen-like activity via ERalpha and ERbeta compared to E2 in the HeLa prolactin array cell line. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 66-73 28466560-8 2017 Targeted inhibition of G protein-coupled estrogen receptor, while not estrogen receptor (ERalpha), abolished BPA-induced IL-6 expression, proliferation, and migration of LSCC cells. bisphenol A 109-112 estrogen receptor 1 Homo sapiens 41-58 28426875-0 2017 Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 130-147 27273787-0 2017 Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERalpha) and Med25. bisphenol A 43-54 estrogen receptor 1 Homo sapiens 84-91 27273787-7 2017 Moreover, we demonstrate that Med25, a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha that interacts with ERalpha through its C-terminal LXXLL motif after BPA exposure, and is functionally involved in BPA-induced transcriptional regulation of CYP2C9 expression and enzyme activity. bisphenol A 194-197 estrogen receptor 1 Homo sapiens 117-124 27273787-7 2017 Moreover, we demonstrate that Med25, a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha that interacts with ERalpha through its C-terminal LXXLL motif after BPA exposure, and is functionally involved in BPA-induced transcriptional regulation of CYP2C9 expression and enzyme activity. bisphenol A 194-197 estrogen receptor 1 Homo sapiens 145-152 27273787-7 2017 Moreover, we demonstrate that Med25, a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha that interacts with ERalpha through its C-terminal LXXLL motif after BPA exposure, and is functionally involved in BPA-induced transcriptional regulation of CYP2C9 expression and enzyme activity. bisphenol A 240-243 estrogen receptor 1 Homo sapiens 117-124 27273787-7 2017 Moreover, we demonstrate that Med25, a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha that interacts with ERalpha through its C-terminal LXXLL motif after BPA exposure, and is functionally involved in BPA-induced transcriptional regulation of CYP2C9 expression and enzyme activity. bisphenol A 240-243 estrogen receptor 1 Homo sapiens 145-152 27880919-1 2017 Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERalpha) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation. bisphenol A 57-68 estrogen receptor 1 Homo sapiens 106-160 27880919-1 2017 Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERalpha) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation. bisphenol A 70-73 estrogen receptor 1 Homo sapiens 106-160 27998958-8 2017 Using specific antagonists for estrogen/androgen receptors, CA in the presence of BPA or its analogues was likely to be mediated via ESR1 signaling. bisphenol A 82-85 estrogen receptor 1 Homo sapiens 133-137 28263540-7 2016 All tested substances were identified as agonists for human estrogen receptor alpha by methods in silico and in vitro, four substances showed a potentially higher estrogenic activity comparing to bisphenol A, two substances were identified as very weak antagonists of human androgen receptor and one compound showed a potential of agonistic activity to human androgen receptor. bisphenol A 196-207 estrogen receptor 1 Homo sapiens 60-83 27745655-1 2016 Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 69-86 27745655-1 2016 Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 88-90 27745655-1 2016 Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 106-108 27745655-1 2016 Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 69-86 27745655-1 2016 Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 88-90 27745655-1 2016 Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 106-108 27156127-4 2016 Through these approaches, we revealed differential binding affinity of bisphenol-A (BPA) and genistein (GEN) to the human ERalpha (ESR1) and ligand-dependent recruitment of SRC-1 and SRC-3 peptides. bisphenol A 71-82 estrogen receptor 1 Homo sapiens 122-129 27156127-4 2016 Through these approaches, we revealed differential binding affinity of bisphenol-A (BPA) and genistein (GEN) to the human ERalpha (ESR1) and ligand-dependent recruitment of SRC-1 and SRC-3 peptides. bisphenol A 71-82 estrogen receptor 1 Homo sapiens 131-135 27156127-4 2016 Through these approaches, we revealed differential binding affinity of bisphenol-A (BPA) and genistein (GEN) to the human ERalpha (ESR1) and ligand-dependent recruitment of SRC-1 and SRC-3 peptides. bisphenol A 84-87 estrogen receptor 1 Homo sapiens 122-129 27156127-4 2016 Through these approaches, we revealed differential binding affinity of bisphenol-A (BPA) and genistein (GEN) to the human ERalpha (ESR1) and ligand-dependent recruitment of SRC-1 and SRC-3 peptides. bisphenol A 84-87 estrogen receptor 1 Homo sapiens 131-135 27480627-6 2016 Both estrogen receptor alpha (ERalpha) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERalpha and GPER. bisphenol A 127-130 estrogen receptor 1 Homo sapiens 5-28 27480627-6 2016 Both estrogen receptor alpha (ERalpha) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERalpha and GPER. bisphenol A 127-130 estrogen receptor 1 Homo sapiens 30-37 27480627-6 2016 Both estrogen receptor alpha (ERalpha) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERalpha and GPER. bisphenol A 127-130 estrogen receptor 1 Homo sapiens 177-184 27480627-7 2016 However, only the inhibitor of ERalpha (ICI 182, 780), and not GPER (G15), can abolish BPA-induced upregulation of Snail. bisphenol A 87-90 estrogen receptor 1 Homo sapiens 31-38 27480627-8 2016 It suggested that ERalpha is involved in BPA-induced EMT of HA cells. bisphenol A 41-44 estrogen receptor 1 Homo sapiens 18-25 27480627-9 2016 Collectively, our data suggested that BPA can trigger the EMT of HA cells via ERalpha/Snail signals. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 78-85 25534675-0 2016 Bisphenol a exposure promotes the migration of NCM460 cells via estrogen receptor-mediated integrin beta1/MMP-9 pathway. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 64-81 27366082-0 2016 Transcription factor activity of estrogen receptor alpha activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells. bisphenol A 88-99 estrogen receptor 1 Homo sapiens 33-56 27366082-1 2016 Many kinds of endocrine-disrupting chemicals (EDCs), for example, the environmental estrogens bisphenol A and nonylphenol, may regulate the activity of estrogen receptor alpha (ERalpha) and therefore induce potential disruption of normal endocrine function. bisphenol A 94-105 estrogen receptor 1 Homo sapiens 152-175 27366082-1 2016 Many kinds of endocrine-disrupting chemicals (EDCs), for example, the environmental estrogens bisphenol A and nonylphenol, may regulate the activity of estrogen receptor alpha (ERalpha) and therefore induce potential disruption of normal endocrine function. bisphenol A 94-105 estrogen receptor 1 Homo sapiens 177-184 27366082-3 2016 In this work, results showed that upon bisphenol A or nonylphenol treatment, the transcription factor activity of ERalpha was significantly increased in neuroblastoma cell line SH-SY5Y. bisphenol A 39-50 estrogen receptor 1 Homo sapiens 114-121 27366082-4 2016 Bisphenol A and nonylphenol could enhance ERalpha activity via recruiting it to the target gene promoter. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 42-49 26363202-2 2015 The present study revealed that nanomolar BPA significantly promoted the proliferation of both estrogen receptor (ER) positive (MCF-7) and negative (SkBr3) breast cancer cells, which was confirmed by up regulation of proliferating cell nuclear antigen (PCNA) and Bcl-2. bisphenol A 42-45 estrogen receptor 1 Homo sapiens 95-112 26363202-2 2015 The present study revealed that nanomolar BPA significantly promoted the proliferation of both estrogen receptor (ER) positive (MCF-7) and negative (SkBr3) breast cancer cells, which was confirmed by up regulation of proliferating cell nuclear antigen (PCNA) and Bcl-2. bisphenol A 42-45 estrogen receptor 1 Homo sapiens 114-116 25933419-7 2015 RESULTS: Low-dose BPA significantly promoted DNA damage, up-regulated c-Myc and other cell-cycle regulatory proteins, and induced proliferation in parallel in estrogen receptor-alpha (ERalpha)-negative mammary cells. bisphenol A 18-21 estrogen receptor 1 Homo sapiens 159-182 25933419-7 2015 RESULTS: Low-dose BPA significantly promoted DNA damage, up-regulated c-Myc and other cell-cycle regulatory proteins, and induced proliferation in parallel in estrogen receptor-alpha (ERalpha)-negative mammary cells. bisphenol A 18-21 estrogen receptor 1 Homo sapiens 184-191 25933419-9 2015 CONCLUSIONS: Low-dose BPA exerted c-Myc-dependent genotoxic and mitogenic effects on ERalpha-negative mammary cells. bisphenol A 22-25 estrogen receptor 1 Homo sapiens 85-92 26529182-4 2015 However, the exposure to BPA alters the immunolabeling pattern of AR, ERalpha, and PCNA. bisphenol A 25-28 estrogen receptor 1 Homo sapiens 70-77 26277401-4 2015 We found that treatment of murine bone marrow-derived cells (BMCs) and human peripheral blood mononuclear cells with BPA induced the expression of ERalpha and IFN-beta, activated the IFN-signaling, and stimulated the expression of the p202 and IFI16 proteins. bisphenol A 117-120 estrogen receptor 1 Homo sapiens 147-154 26445054-6 2015 Interestingly, ERalpha, ERbeta, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. bisphenol A 87-90 estrogen receptor 1 Homo sapiens 15-22 26021997-7 2015 At the non-toxic concentrations used, BPA perturbed the expression of ERalpha, ERbeta, PRA, PRB, and hCG/LH-R (P<0.05). bisphenol A 38-41 estrogen receptor 1 Homo sapiens 70-77 26133781-6 2015 Lastly, as treatments by an estrogen receptor antagonist suppressed the negative effects on ERK 1/2 phosphorylation observed in cells treated either alone with BPA, DEHP, 4-OP or with the combined treatment of BPA and DEHP, we suggested that estrogen receptor-dependent pathway is involved in mediating the effects of EDCs on human immune system. bisphenol A 160-163 estrogen receptor 1 Homo sapiens 28-45 26133781-6 2015 Lastly, as treatments by an estrogen receptor antagonist suppressed the negative effects on ERK 1/2 phosphorylation observed in cells treated either alone with BPA, DEHP, 4-OP or with the combined treatment of BPA and DEHP, we suggested that estrogen receptor-dependent pathway is involved in mediating the effects of EDCs on human immune system. bisphenol A 210-213 estrogen receptor 1 Homo sapiens 28-45 26133781-6 2015 Lastly, as treatments by an estrogen receptor antagonist suppressed the negative effects on ERK 1/2 phosphorylation observed in cells treated either alone with BPA, DEHP, 4-OP or with the combined treatment of BPA and DEHP, we suggested that estrogen receptor-dependent pathway is involved in mediating the effects of EDCs on human immune system. bisphenol A 210-213 estrogen receptor 1 Homo sapiens 242-259 25690832-0 2015 A new bisphenol A derivative for estrogen receptor binding studies with surface plasmon resonance. bisphenol A 6-17 estrogen receptor 1 Homo sapiens 33-50 26098999-0 2015 Prepubertal exposure to bisphenol-A induces ERalpha upregulation and hyperplasia in adult gerbil female prostate. bisphenol A 24-35 estrogen receptor 1 Homo sapiens 44-51 26098999-4 2015 Morphological, stereological and chemical analyses revealed that long-term BPA exposure, even in environmental dosages, increases the proliferative status of the prostate, increases the number of ERalpha-positive stromal cells and elicits the development of prostatic hyperplasia in adult female gerbils. bisphenol A 75-78 estrogen receptor 1 Homo sapiens 196-203 26855429-2 2015 Their function is regulated by estrogens and estrogen receptors (ERs), but the effect of estrogenic compounds such as bisphenol A (BPA; an agonist of ER-beta and agonist and antagonist of ER-alpha) and (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol (THC; an agonist of ER-alpha and antagonist of ER-beta) on human EPCs is unknown. bisphenol A 118-129 estrogen receptor 1 Homo sapiens 279-287 26855429-7 2015 Moreover, both 10(-5) M THC and 10(-8) M BPA blocked migration in female EPCs, allowing us to hypothesize that the effect is mediated by ER-alpha. bisphenol A 41-44 estrogen receptor 1 Homo sapiens 137-145 25813067-7 2015 Due to its phenolic structure BPA has been shown to interact with estrogen receptors and to act as agonist or antagonist via estrogen receptor (ER) dependent signalling pathways. bisphenol A 30-33 estrogen receptor 1 Homo sapiens 66-83 25813067-7 2015 Due to its phenolic structure BPA has been shown to interact with estrogen receptors and to act as agonist or antagonist via estrogen receptor (ER) dependent signalling pathways. bisphenol A 30-33 estrogen receptor 1 Homo sapiens 144-146 25143472-7 2014 Additionally, we found that BPA increased transcription of the estrogen receptor (ER (ESR1)) and that treatment with the ER antagonist ICI 182 780, blocked the effects of BPA, indicating that BPA may act via an ER-mediated pathway. bisphenol A 28-31 estrogen receptor 1 Homo sapiens 82-84 25143472-7 2014 Additionally, we found that BPA increased transcription of the estrogen receptor (ER (ESR1)) and that treatment with the ER antagonist ICI 182 780, blocked the effects of BPA, indicating that BPA may act via an ER-mediated pathway. bisphenol A 28-31 estrogen receptor 1 Homo sapiens 86-90 25143472-7 2014 Additionally, we found that BPA increased transcription of the estrogen receptor (ER (ESR1)) and that treatment with the ER antagonist ICI 182 780, blocked the effects of BPA, indicating that BPA may act via an ER-mediated pathway. bisphenol A 171-174 estrogen receptor 1 Homo sapiens 121-123 25143472-7 2014 Additionally, we found that BPA increased transcription of the estrogen receptor (ER (ESR1)) and that treatment with the ER antagonist ICI 182 780, blocked the effects of BPA, indicating that BPA may act via an ER-mediated pathway. bisphenol A 171-174 estrogen receptor 1 Homo sapiens 121-123 25371027-3 2014 In this study, the estrogenic potency induced by the binding of 17-beta-estradiol (E2), BPA, BPS, PES and their metabolites formed by the rat liver S9 fraction to the human estrogen receptor (ER) was estimated. bisphenol A 88-91 estrogen receptor 1 Homo sapiens 173-190 25371027-3 2014 In this study, the estrogenic potency induced by the binding of 17-beta-estradiol (E2), BPA, BPS, PES and their metabolites formed by the rat liver S9 fraction to the human estrogen receptor (ER) was estimated. bisphenol A 88-91 estrogen receptor 1 Homo sapiens 192-194 25233466-0 2014 Atomic insights into distinct hormonal activities of Bisphenol A analogues toward PPARgamma and ERalpha receptors. bisphenol A 53-64 estrogen receptor 1 Homo sapiens 96-103 25180905-14 2014 As a result, a 10 min surge of BPA from pM to nM could drive the fraction of BPA-activated ERalpha to a potent 0.1%. bisphenol A 31-34 estrogen receptor 1 Homo sapiens 91-98 25180905-14 2014 As a result, a 10 min surge of BPA from pM to nM could drive the fraction of BPA-activated ERalpha to a potent 0.1%. bisphenol A 77-80 estrogen receptor 1 Homo sapiens 91-98 25128825-4 2014 BPA effected cytokines expression through estrogen receptor alpha/beta (ERalpha/beta)-dependent mechanism with the evidence of ERalpha/beta antagonist reversed the expression of cytokines. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 42-65 25128825-4 2014 BPA effected cytokines expression through estrogen receptor alpha/beta (ERalpha/beta)-dependent mechanism with the evidence of ERalpha/beta antagonist reversed the expression of cytokines. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 66-84 25128825-4 2014 BPA effected cytokines expression through estrogen receptor alpha/beta (ERalpha/beta)-dependent mechanism with the evidence of ERalpha/beta antagonist reversed the expression of cytokines. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 72-84 24793927-5 2014 RESULTS: BPA promoted the growth of UL cells and the expressions of ERalpha, IGF-1 and VEGF, which had positive correlation with the concentration and action time of BPA treatment. bisphenol A 9-12 estrogen receptor 1 Homo sapiens 68-75 24793927-5 2014 RESULTS: BPA promoted the growth of UL cells and the expressions of ERalpha, IGF-1 and VEGF, which had positive correlation with the concentration and action time of BPA treatment. bisphenol A 166-169 estrogen receptor 1 Homo sapiens 68-75 24856822-3 2014 Here, we describe the use of multiparametric, HT microscopy-based platforms to examine how a prototypical EDC, bisphenol A (BPA), and 18 poorly studied BPA analogs (BPXs), affect estrogen receptor (ER). bisphenol A 111-122 estrogen receptor 1 Homo sapiens 179-196 24856822-3 2014 Here, we describe the use of multiparametric, HT microscopy-based platforms to examine how a prototypical EDC, bisphenol A (BPA), and 18 poorly studied BPA analogs (BPXs), affect estrogen receptor (ER). bisphenol A 124-127 estrogen receptor 1 Homo sapiens 179-196 24856822-3 2014 Here, we describe the use of multiparametric, HT microscopy-based platforms to examine how a prototypical EDC, bisphenol A (BPA), and 18 poorly studied BPA analogs (BPXs), affect estrogen receptor (ER). bisphenol A 152-155 estrogen receptor 1 Homo sapiens 179-196 24856822-4 2014 We show that short exposure to BPA and most BPXs induces ERalpha and/or ERbeta loading to DNA changing target gene transcription. bisphenol A 31-34 estrogen receptor 1 Homo sapiens 57-64 24496634-9 2014 The assay suggested that bisphenol A (BPA) functions mainly as an ER agonist. bisphenol A 25-36 estrogen receptor 1 Homo sapiens 66-68 24496634-9 2014 The assay suggested that bisphenol A (BPA) functions mainly as an ER agonist. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 66-68 24201004-3 2014 Thiol-labeled long chain hydrocarbon with bisphenol A (BPA) as head group was synthesized and self-assembled on the Au nanoparticle surface as the sensing probes, which showed a linear response upon the binding of estrogen receptor (ER-alpha) ranging from 1 to 30 nM. bisphenol A 42-53 estrogen receptor 1 Homo sapiens 214-231 24201004-3 2014 Thiol-labeled long chain hydrocarbon with bisphenol A (BPA) as head group was synthesized and self-assembled on the Au nanoparticle surface as the sensing probes, which showed a linear response upon the binding of estrogen receptor (ER-alpha) ranging from 1 to 30 nM. bisphenol A 42-53 estrogen receptor 1 Homo sapiens 233-241 24201004-3 2014 Thiol-labeled long chain hydrocarbon with bisphenol A (BPA) as head group was synthesized and self-assembled on the Au nanoparticle surface as the sensing probes, which showed a linear response upon the binding of estrogen receptor (ER-alpha) ranging from 1 to 30 nM. bisphenol A 55-58 estrogen receptor 1 Homo sapiens 214-231 24201004-3 2014 Thiol-labeled long chain hydrocarbon with bisphenol A (BPA) as head group was synthesized and self-assembled on the Au nanoparticle surface as the sensing probes, which showed a linear response upon the binding of estrogen receptor (ER-alpha) ranging from 1 to 30 nM. bisphenol A 55-58 estrogen receptor 1 Homo sapiens 233-241 24284790-2 2014 A number of EDCs, including bisphenol A (BPA) can bind to the estrogen receptors (ER), ERalpha and ERbeta, and may contribute to estrogen-linked diseases such as breast cancer. bisphenol A 28-39 estrogen receptor 1 Homo sapiens 87-94 24284790-2 2014 A number of EDCs, including bisphenol A (BPA) can bind to the estrogen receptors (ER), ERalpha and ERbeta, and may contribute to estrogen-linked diseases such as breast cancer. bisphenol A 41-44 estrogen receptor 1 Homo sapiens 87-94 24586459-4 2014 Here, the effects of bisphenol A (BPA) and naringenin (Nar), prototypes of synthetic and plant-derived ERalpha ligands, have been evaluated on ERalpha levels in MCF-7 cells. bisphenol A 21-32 estrogen receptor 1 Homo sapiens 143-150 25130739-2 2014 Here, we have shown that BPA binds both estrogen receptor (ER)-alpha and ER-beta (ER-beta) using a fluorescence polarization competitive binding assay. bisphenol A 25-28 estrogen receptor 1 Homo sapiens 40-68 23959105-7 2013 Typical serum BPA concentrations are orders of magnitude lower than levels measurable by modern analytical methods and below concentrations required to occupy more than 0.0009% of Type II Estrogen Binding Sites, GPR30, ERalpha or ERbeta receptors. bisphenol A 14-17 estrogen receptor 1 Homo sapiens 219-226 23973438-3 2013 Although most of the effects related to BPA exposure have been linked to the activation of the estrogen receptor (ER), the mechanisms of the interaction of BPA with protein targets different from ER are still unknown. bisphenol A 40-43 estrogen receptor 1 Homo sapiens 95-112 23973438-3 2013 Although most of the effects related to BPA exposure have been linked to the activation of the estrogen receptor (ER), the mechanisms of the interaction of BPA with protein targets different from ER are still unknown. bisphenol A 40-43 estrogen receptor 1 Homo sapiens 114-116 24156707-7 2013 RESULTS: Estrogenic effect of BPA was confirmed in the following checkpoints: mRNA expression of estrogen receptor alpha, expression of cyclin D1 and A2 proteins and CCNA2 gene, Bax and Bcl2 protein levels. bisphenol A 30-33 estrogen receptor 1 Homo sapiens 97-120 23810794-4 2013 BPA induced a significant increase in BG-1 cell growth and up-regulated mRNA levels of ERalpha and IGF-1R. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 87-94 23682706-6 2013 A linear growth response was observed in response to prototypical estrogen receptor agonists (17beta-estradiol, genistein, bisphenol A, nonylphenol, and 4-tert-octylphenol). bisphenol A 123-134 estrogen receptor 1 Homo sapiens 66-83 23768907-0 2013 Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERalpha-selective antagonist. bisphenol A 36-47 estrogen receptor 1 Homo sapiens 101-108 23373633-3 2013 This study determined the molecular mechanism of oestrogen-agonistic/antagonistic action of structurally similar ligands, bisphenol (BP) and bisphenol A (BPA) on cell proliferation and apoptosis of ERalpha + ve breast cancer cells. bisphenol A 141-152 estrogen receptor 1 Homo sapiens 198-205 23373633-3 2013 This study determined the molecular mechanism of oestrogen-agonistic/antagonistic action of structurally similar ligands, bisphenol (BP) and bisphenol A (BPA) on cell proliferation and apoptosis of ERalpha + ve breast cancer cells. bisphenol A 154-157 estrogen receptor 1 Homo sapiens 198-205 23384675-9 2013 Bisphenol A, bisphenol AF, and 2-2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (group 1) strongly activated ERalpha estrogen responsive element (ERE)-mediated responses. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 107-114 23222814-7 2013 BPA exposure induced an increase in the ERalpha (Estrogen Receptor): ERbeta ratio--an effect also reversed by curcumin (analysis of variance, P < 0.02 for all test proteins). bisphenol A 0-3 estrogen receptor 1 Homo sapiens 40-47 23222814-7 2013 BPA exposure induced an increase in the ERalpha (Estrogen Receptor): ERbeta ratio--an effect also reversed by curcumin (analysis of variance, P < 0.02 for all test proteins). bisphenol A 0-3 estrogen receptor 1 Homo sapiens 49-66 23710174-7 2013 In infertile women, a positive association was found between BPA and MEHP levels and ER alpha , ER beta , AR, AhR, and PXR expression. bisphenol A 61-64 estrogen receptor 1 Homo sapiens 85-93 23019147-0 2012 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. bisphenol A 14-25 estrogen receptor 1 Homo sapiens 41-60 23019147-5 2012 GEN and BPA treatment induces thousands of ESR1 binding sites and >50 gene expression changes, representing a subset of E2-induced gene regulation changes. bisphenol A 8-11 estrogen receptor 1 Homo sapiens 43-47 23019147-7 2012 Treatment-dependent changes in gene expression were associated with treatment-dependent ESR1 binding sites, with the exception that many genes up-regulated by E2 harbored a BPA-induced ESR1 binding site but failed to show any expression change after BPA treatment. bisphenol A 173-176 estrogen receptor 1 Homo sapiens 185-189 22552965-2 2012 BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ERalpha and ERbeta) and through the G protein-coupled receptor (GPR30/GPER). bisphenol A 0-3 estrogen receptor 1 Homo sapiens 88-95 22692793-5 2012 Although both Nar and BPA bind to ERalpha, they induce opposite effects on breast cancer cell growth. bisphenol A 22-25 estrogen receptor 1 Homo sapiens 34-41 22912978-4 2012 The results showed that BPA possessed various activities on ER, AR and TR. bisphenol A 24-27 estrogen receptor 1 Homo sapiens 60-62 22494775-7 2012 At lower concentrations, BPA acted as an antagonist for ERalpha in Ishikawa cells and BPAF acted as an antagonist for ERbeta in HeLa cells, whereas Zea was only a partial antagonist for ERalpha. bisphenol A 25-28 estrogen receptor 1 Homo sapiens 56-63 22494775-8 2012 ERE-mediated activation by BPA and BPAF was via the AF-2 function of ERalpha, but Zea activated via both the AF-1 and AF-2 functions. bisphenol A 27-30 estrogen receptor 1 Homo sapiens 69-76 22494775-10 2012 CONCLUSION: BPA and BPAF can function as EDCs by acting as cell type-specific agonists (>= 10 nM) or antagonists (<= 10 nM) for ERalpha and ERbeta. bisphenol A 12-15 estrogen receptor 1 Homo sapiens 134-141 22561550-12 2012 Pre-treatment with an Eralpha antagonist (tamoxifen) blocked the BPA-induced decrease in CAP parameters. bisphenol A 65-68 estrogen receptor 1 Homo sapiens 22-29 22504913-4 2012 Whereas both genistein and bisphenol A induce genomic estrogen receptor (ER) signaling in the developing uterus, only genistein induced phosphoinositide 3-kinase (PI3K)/AKT nongenomic ER signaling to the histone methyltransferase enhancer of zeste homolog 2 (EZH2). bisphenol A 27-38 estrogen receptor 1 Homo sapiens 54-71 22504913-4 2012 Whereas both genistein and bisphenol A induce genomic estrogen receptor (ER) signaling in the developing uterus, only genistein induced phosphoinositide 3-kinase (PI3K)/AKT nongenomic ER signaling to the histone methyltransferase enhancer of zeste homolog 2 (EZH2). bisphenol A 27-38 estrogen receptor 1 Homo sapiens 73-75 23056236-0 2012 3D models of MBP, a biologically active metabolite of bisphenol A, in human estrogen receptor alpha and estrogen receptor beta. bisphenol A 54-65 estrogen receptor 1 Homo sapiens 76-99 23056236-1 2012 Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor alpha [ERalpha] and ERbeta in cell culture. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 156-179 23056236-1 2012 Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor alpha [ERalpha] and ERbeta in cell culture. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 181-188 23056236-1 2012 Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor alpha [ERalpha] and ERbeta in cell culture. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 156-179 23056236-1 2012 Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor alpha [ERalpha] and ERbeta in cell culture. bisphenol A 13-16 estrogen receptor 1 Homo sapiens 181-188 23056236-1 2012 Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor alpha [ERalpha] and ERbeta in cell culture. bisphenol A 99-102 estrogen receptor 1 Homo sapiens 156-179 23056236-1 2012 Bisphenol A [BPA] is a widely dispersed environmental chemical that is of much concern because the BPA monomer is a weak transcriptional activator of human estrogen receptor alpha [ERalpha] and ERbeta in cell culture. bisphenol A 99-102 estrogen receptor 1 Homo sapiens 181-188 23056236-3 2012 To investigate the structural basis for the activity of MBP at nM concentrations and the lower activity of BPA for human ERalpha and ERbeta, we constructed 3D models of human ERalpha and ERbeta with MBP and BPA for comparison with estradiol in these ERs. bisphenol A 107-110 estrogen receptor 1 Homo sapiens 121-128 23056236-5 2012 Metabolism of BPA to MBP increases the spacing between two phenolic rings, resulting in contacts between MBP and ERalpha and ERbeta that mimic those of estradiol with these ERs. bisphenol A 14-17 estrogen receptor 1 Homo sapiens 113-120 21618468-0 2011 Developing a compound-specific receptor for bisphenol A by directed evolution of human estrogen receptor alpha. bisphenol A 44-55 estrogen receptor 1 Homo sapiens 87-110 21618468-2 2011 In this study, directed evolution was used to generate a mutant human estrogen receptor alpha library, which was then used to screen for receptors having enhanced responses to the known endocrine-disrupting chemical, bisphenol A (BPA). bisphenol A 217-228 estrogen receptor 1 Homo sapiens 70-93 21618468-2 2011 In this study, directed evolution was used to generate a mutant human estrogen receptor alpha library, which was then used to screen for receptors having enhanced responses to the known endocrine-disrupting chemical, bisphenol A (BPA). bisphenol A 230-233 estrogen receptor 1 Homo sapiens 70-93 21771643-6 2011 ARNT2 expression was downregulated by BPA, BBP, and o,p"-DDT in a dose-dependent manner in estrogen receptor 1 (ESR1)-positive MCF-7 and BG1Luc4E2 cells, but not in estrogen receptor-negative LNCaP cells. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 91-110 21771643-6 2011 ARNT2 expression was downregulated by BPA, BBP, and o,p"-DDT in a dose-dependent manner in estrogen receptor 1 (ESR1)-positive MCF-7 and BG1Luc4E2 cells, but not in estrogen receptor-negative LNCaP cells. bisphenol A 38-41 estrogen receptor 1 Homo sapiens 112-116 21561829-10 2011 We also found evidence that activation of ERalpha, ERbeta, and PPARgamma depends on the degree of halogenation in BPA analogs. bisphenol A 114-117 estrogen receptor 1 Homo sapiens 42-49 21622942-0 2011 Characterization of novel ligands of ERalpha, Erbeta, and PPARgamma: the case of halogenated bisphenol A and their conjugated metabolites. bisphenol A 93-104 estrogen receptor 1 Homo sapiens 37-44 21826169-1 2011 Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels of altered genes in estrogen receptor (ER)-positive BG-1 ovarian cancer cells by microarray and real-time polymerase-chain reaction. bisphenol A 156-167 estrogen receptor 1 Homo sapiens 224-241 21826169-1 2011 Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels of altered genes in estrogen receptor (ER)-positive BG-1 ovarian cancer cells by microarray and real-time polymerase-chain reaction. bisphenol A 156-167 estrogen receptor 1 Homo sapiens 243-245 21826169-1 2011 Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels of altered genes in estrogen receptor (ER)-positive BG-1 ovarian cancer cells by microarray and real-time polymerase-chain reaction. bisphenol A 169-172 estrogen receptor 1 Homo sapiens 224-241 21826169-1 2011 Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels of altered genes in estrogen receptor (ER)-positive BG-1 ovarian cancer cells by microarray and real-time polymerase-chain reaction. bisphenol A 169-172 estrogen receptor 1 Homo sapiens 243-245 21826169-4 2011 These results indicate that BPA in parallel with E(2) induced the transcriptional levels of E(2)-responsive genes in an estrogen receptor (ER)-positive BG-1 cells. bisphenol A 28-31 estrogen receptor 1 Homo sapiens 120-137 21826169-4 2011 These results indicate that BPA in parallel with E(2) induced the transcriptional levels of E(2)-responsive genes in an estrogen receptor (ER)-positive BG-1 cells. bisphenol A 28-31 estrogen receptor 1 Homo sapiens 139-141 21826169-5 2011 In conclusion, these microarray and real-time polymerase-chain reaction results indicate that BPA, a potential weak estrogen, may have estrogenic effect by regulating E(2)-responsive genes in ER-positive BG-1 cells and BG-1 cells would be the best in vitro model to detect these estrogenic EDCs. bisphenol A 94-97 estrogen receptor 1 Homo sapiens 192-194 21163906-8 2011 PFOA, PFNA, PFDA, and PFOS all efficiently docked with ERalpha from different species and formed a hydrogen bond at residue Arg394/398/407 (human/mouse/trout) in a manner similar to the environmental estrogens bisphenol A and nonylphenol. bisphenol A 210-221 estrogen receptor 1 Homo sapiens 55-62 20875696-4 2011 BPA induced a rapid activation of Erk1/2 in both ERalpha/beta-positive and negative breast cancer cells, and this effect was not blocked with an ER antagonist, ICI 182,780. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 49-56 20858508-0 2010 Bisphenol-A rapidly promotes dynamic changes in hippocampal dendritic morphology through estrogen receptor-mediated pathway by concomitant phosphorylation of NMDA receptor subunit NR2B. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 89-106 20678512-5 2010 We also investigated the effect of BPA on the ERalpha signaling pathway and global gene expression profiles. bisphenol A 35-38 estrogen receptor 1 Homo sapiens 46-53 20678512-6 2010 Compared to control cells, nuclear internalization of ERalpha was observed in epithelial cells preexposed to BPA. bisphenol A 109-112 estrogen receptor 1 Homo sapiens 54-61 20427257-3 2010 OBJECTIVES: We aimed to determine the relative preference of bisphenol AF for the human nuclear estrogenic receptors ERalpha and ERbeta and the bisphenol A-specific estrogen-related receptor ERRgamma, and to clarify structural characteristics of receptors that influence bisphenol AF binding. bisphenol A 61-72 estrogen receptor 1 Homo sapiens 117-124 20836126-1 2010 Bisphenol A (BPA), a prototype of endocrine disruptors, mimics 17beta-estradiol (E2)-induced proliferation in several cancer cells by binding to estrogen receptor alpha (ERalpha). bisphenol A 0-11 estrogen receptor 1 Homo sapiens 145-168 20836126-1 2010 Bisphenol A (BPA), a prototype of endocrine disruptors, mimics 17beta-estradiol (E2)-induced proliferation in several cancer cells by binding to estrogen receptor alpha (ERalpha). bisphenol A 0-11 estrogen receptor 1 Homo sapiens 170-177 20836126-1 2010 Bisphenol A (BPA), a prototype of endocrine disruptors, mimics 17beta-estradiol (E2)-induced proliferation in several cancer cells by binding to estrogen receptor alpha (ERalpha). bisphenol A 13-16 estrogen receptor 1 Homo sapiens 145-168 20836126-1 2010 Bisphenol A (BPA), a prototype of endocrine disruptors, mimics 17beta-estradiol (E2)-induced proliferation in several cancer cells by binding to estrogen receptor alpha (ERalpha). bisphenol A 13-16 estrogen receptor 1 Homo sapiens 170-177 19765641-3 2010 It was found that 4-t-OP, 3,4-DCP, PCP, BPA, TBBPA, TCBPA and 4-phenylphenol were ERalpha agonists, while 4-t-OP, PCP and 4-phenylphenol showed ERalpha antagonistic activities. bisphenol A 40-43 estrogen receptor 1 Homo sapiens 82-89 19269315-0 2009 Increase in the levels of chaperone proteins by exposure to beta-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor alpha cDNA. bisphenol A 76-87 estrogen receptor 1 Homo sapiens 140-163 19433249-5 2009 Activation of ERalpha by 17beta-estradiol (E2) and the environmental estrogen bisphenol-A (BPA) promotes an increase of insulin biosynthesis through a non-classical estrogen-activated pathway that involves phosphorylation of ERK1/2. bisphenol A 78-89 estrogen receptor 1 Homo sapiens 14-21 19433249-5 2009 Activation of ERalpha by 17beta-estradiol (E2) and the environmental estrogen bisphenol-A (BPA) promotes an increase of insulin biosynthesis through a non-classical estrogen-activated pathway that involves phosphorylation of ERK1/2. bisphenol A 91-94 estrogen receptor 1 Homo sapiens 14-21 19433249-7 2009 However, if ERalpha is over stimulated by an excess of E2 or the action of an environmental estrogen such as BPA, it will produce an excessive insulin signaling. bisphenol A 109-112 estrogen receptor 1 Homo sapiens 12-19 19303279-0 2009 Fast picomolar selective detection of bisphenol A in water using a carbon nanotube field effect transistor functionalized with estrogen receptor-alpha. bisphenol A 38-49 estrogen receptor 1 Homo sapiens 127-150 19492024-5 2009 In the present study, to test whether ERalpha is essential to the BPA-induced proliferation on MCF-7 cells, we suppressed the ERalpha expression of MCF-7 cells by RNA interference (RNAi). bisphenol A 66-69 estrogen receptor 1 Homo sapiens 38-45 19270784-0 2009 Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 62-85 19270784-5 2009 OBJECTIVE: The objective of our study was to determine whether BPA at low nanomolar concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in the estrogen receptor-alpha (ERalpha)-positive T47D and the ERalpha-negative MDA-MB-468 breast cancer cells. bisphenol A 63-66 estrogen receptor 1 Homo sapiens 168-191 19270784-5 2009 OBJECTIVE: The objective of our study was to determine whether BPA at low nanomolar concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in the estrogen receptor-alpha (ERalpha)-positive T47D and the ERalpha-negative MDA-MB-468 breast cancer cells. bisphenol A 63-66 estrogen receptor 1 Homo sapiens 193-200 19270784-5 2009 OBJECTIVE: The objective of our study was to determine whether BPA at low nanomolar concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in the estrogen receptor-alpha (ERalpha)-positive T47D and the ERalpha-negative MDA-MB-468 breast cancer cells. bisphenol A 63-66 estrogen receptor 1 Homo sapiens 224-231 19270784-9 2009 RESULTS: BPA antagonizes the cytotoxicity of multiple chemotherapeutic agents in both ERalpha-positive and -negative breast cancer cells independent of the classical ERs. bisphenol A 9-12 estrogen receptor 1 Homo sapiens 86-93 18767177-0 2008 Laccase treatment impairs bisphenol A-induced cancer cell proliferation affecting estrogen receptor alpha-dependent rapid signals. bisphenol A 26-37 estrogen receptor 1 Homo sapiens 82-105 18767177-3 2008 BPA, highly present in natural world and considered as a model of environmental estrogen action complexity, promotes human cancer cell proliferation via ERalpha-dependent signal transduction pathways. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 153-160 18767177-6 2008 Notably, high BPA concentrations (i.e., 0.1 and 1 mM) are cytotoxic even in ERalpha-devoid cancer cells, indicating that an ERalpha-independent mechanism participates to BPA-induced cytotoxicity. bisphenol A 14-17 estrogen receptor 1 Homo sapiens 76-83 18767177-6 2008 Notably, high BPA concentrations (i.e., 0.1 and 1 mM) are cytotoxic even in ERalpha-devoid cancer cells, indicating that an ERalpha-independent mechanism participates to BPA-induced cytotoxicity. bisphenol A 14-17 estrogen receptor 1 Homo sapiens 124-131 18767177-6 2008 Notably, high BPA concentrations (i.e., 0.1 and 1 mM) are cytotoxic even in ERalpha-devoid cancer cells, indicating that an ERalpha-independent mechanism participates to BPA-induced cytotoxicity. bisphenol A 170-173 estrogen receptor 1 Homo sapiens 124-131 18767177-7 2008 On the other hand, BPA oxidation by laccase impairs the binding of this environmental estrogen to ERalpha loosing at all ERalpha-dependent effect on cancer cell proliferation. bisphenol A 19-22 estrogen receptor 1 Homo sapiens 98-105 18767177-7 2008 On the other hand, BPA oxidation by laccase impairs the binding of this environmental estrogen to ERalpha loosing at all ERalpha-dependent effect on cancer cell proliferation. bisphenol A 19-22 estrogen receptor 1 Homo sapiens 121-128 18544561-1 2008 Reports of the ability of estrogenic agents such as 17beta-estradiol (E2), estriol (E3) and bisphenol A (BPA) to induce micronuclei (MN) in MCF-7 breast cancer cells have prompted us to investigate whether these effects are linked to activation of the estrogen receptor (ER) alpha. bisphenol A 92-103 estrogen receptor 1 Homo sapiens 252-280 18544561-1 2008 Reports of the ability of estrogenic agents such as 17beta-estradiol (E2), estriol (E3) and bisphenol A (BPA) to induce micronuclei (MN) in MCF-7 breast cancer cells have prompted us to investigate whether these effects are linked to activation of the estrogen receptor (ER) alpha. bisphenol A 105-108 estrogen receptor 1 Homo sapiens 252-280 18005256-2 2007 Bisphenol A, 2,2-bis(4-hydroxyphenyl)propane, is an estrogenic endocrine disruptor that influences various physiological functions at very low doses, even though bisphenol A itself is ineffectual as a ligand for the estrogen receptor. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 216-233 17941731-5 2007 Bisphenol A (compound 3) and 2-naphthol (compound 1) exhibited activity in the assays of both hERalpha and medERalpha without the S9 mix. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 94-117 17031755-5 2007 Estrogenic activities of the degradation pathways of the BPA in water were assessed by using a constructed yeast two-hybrid assay system for human estrogen receptor alpha (hERalpha) and Japanese medaka fish (Oryzias latipes) estrogen receptor alpha (medERalpha). bisphenol A 57-60 estrogen receptor 1 Homo sapiens 147-170 17031755-5 2007 Estrogenic activities of the degradation pathways of the BPA in water were assessed by using a constructed yeast two-hybrid assay system for human estrogen receptor alpha (hERalpha) and Japanese medaka fish (Oryzias latipes) estrogen receptor alpha (medERalpha). bisphenol A 57-60 estrogen receptor 1 Homo sapiens 172-180 17031755-5 2007 Estrogenic activities of the degradation pathways of the BPA in water were assessed by using a constructed yeast two-hybrid assay system for human estrogen receptor alpha (hERalpha) and Japanese medaka fish (Oryzias latipes) estrogen receptor alpha (medERalpha). bisphenol A 57-60 estrogen receptor 1 Homo sapiens 225-248 17031755-6 2007 Estrogenic activity for hERalpha and medERalpha was reduced to less than 20% of the initial activity for BPA after 240 min of UV irradiation. bisphenol A 105-108 estrogen receptor 1 Homo sapiens 24-47 16328721-3 2006 We examined the effect of two prevalent xenoestrogens (bisphenol A and coumestrol) on ER activation and ER-dependent mitogenesis in breast cancer cells. bisphenol A 55-66 estrogen receptor 1 Homo sapiens 104-106 16328721-3 2006 We examined the effect of two prevalent xenoestrogens (bisphenol A and coumestrol) on ER activation and ER-dependent mitogenesis in breast cancer cells. bisphenol A 55-66 estrogen receptor 1 Homo sapiens 86-88 16328721-8 2006 Although the xenoestrogens failed to alter ER-Y537S function, the ER-D351Y mutant demonstrated an enhanced response to bisphenol A. bisphenol A 119-130 estrogen receptor 1 Homo sapiens 66-68 16328721-11 2006 Bisphenol A and coumestrol exhibited differential responses to co-activators with regard to ER activation. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 92-94 16328721-13 2006 Combined, these data demonstrate that bisphenol A and coumestrol can impact ER activity and ER-dependent proliferation in breast cancer cells, but the influence of these agents is restricted to conditions of estrogen depletion, selective mutation of the ER, and expression of specific co-activators. bisphenol A 38-49 estrogen receptor 1 Homo sapiens 76-78 16328721-13 2006 Combined, these data demonstrate that bisphenol A and coumestrol can impact ER activity and ER-dependent proliferation in breast cancer cells, but the influence of these agents is restricted to conditions of estrogen depletion, selective mutation of the ER, and expression of specific co-activators. bisphenol A 38-49 estrogen receptor 1 Homo sapiens 92-94 16328721-13 2006 Combined, these data demonstrate that bisphenol A and coumestrol can impact ER activity and ER-dependent proliferation in breast cancer cells, but the influence of these agents is restricted to conditions of estrogen depletion, selective mutation of the ER, and expression of specific co-activators. bisphenol A 38-49 estrogen receptor 1 Homo sapiens 92-94 16029874-0 2006 Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. bisphenol A 54-65 estrogen receptor 1 Homo sapiens 69-92 16029874-4 2006 Using a yeast strain incorporating a vitellogenin A2 ERE-LacZ reporter gene into the genome, we found that BPA induced expression of the reporter in colonies transformed with the ERalpha expression plasmid, illustrating BPA-mediated regulation within a chromatin context. bisphenol A 107-110 estrogen receptor 1 Homo sapiens 179-186 16029874-4 2006 Using a yeast strain incorporating a vitellogenin A2 ERE-LacZ reporter gene into the genome, we found that BPA induced expression of the reporter in colonies transformed with the ERalpha expression plasmid, illustrating BPA-mediated regulation within a chromatin context. bisphenol A 220-223 estrogen receptor 1 Homo sapiens 179-186 15596252-2 2005 BPA and its chlorinated derivatives were active in competing with [3H]17beta-estradiol for their binding to the human ERalpha and ERbeta proteins. bisphenol A 0-3 estrogen receptor 1 Homo sapiens 118-125 15116845-5 2004 For the xeno-estrogenic activity of BPA and the metabolites, their ability to bind to recombinant human estrogen receptor alpha in competition with fluorescence-labeled 17beta-estradiol was measured. bisphenol A 36-39 estrogen receptor 1 Homo sapiens 104-127 14691209-9 2004 It is noteworthy that the estrogenic activity of MBP, the active metabolite of BPA, is much more potent than that of the parent BPA in several assays, including two reporter assays using a recombinant yeast expressing human estrogen receptor alpha and an MCF-7-transfected firefly luciferase plasmid. bisphenol A 79-82 estrogen receptor 1 Homo sapiens 224-247 15750583-0 2004 Transient inhibition of synergistically insulin-like growth factor-1- and bisphenol A-induced poliferation of estrogen receptor alpha (ERalpha)-positive human breast cancer MCF-7 cells by melatonin. bisphenol A 74-85 estrogen receptor 1 Homo sapiens 110-133 15750583-0 2004 Transient inhibition of synergistically insulin-like growth factor-1- and bisphenol A-induced poliferation of estrogen receptor alpha (ERalpha)-positive human breast cancer MCF-7 cells by melatonin. bisphenol A 74-85 estrogen receptor 1 Homo sapiens 135-142 15750583-6 2004 Thus, melatonin caused a transient inhibition of cell growth of estrogen receptor alpha (ERalpha)-positive MCF-7-EMF cells induced synergistically by both IGF-1 and bisphenol A. bisphenol A 165-176 estrogen receptor 1 Homo sapiens 64-87 15750583-6 2004 Thus, melatonin caused a transient inhibition of cell growth of estrogen receptor alpha (ERalpha)-positive MCF-7-EMF cells induced synergistically by both IGF-1 and bisphenol A. bisphenol A 165-176 estrogen receptor 1 Homo sapiens 89-96 14709801-0 2003 The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells. bisphenol A 22-33 estrogen receptor 1 Homo sapiens 72-95 14664715-3 2003 We present evidence that the EDCs bisphenol A and phthalate activate ER-mediated transcription through interaction with TRAP220. bisphenol A 34-45 estrogen receptor 1 Homo sapiens 69-71 12818366-7 2003 4OHPB as well as diethylstilbestrol (DES) and bisphenol A (BPA), which are known xenoestrogenic compounds, competitively displaced 17beta-estradiol bound to the estrogen receptor alpha in a concentration-dependent manner; IC(50) values of these compounds were approximately 1 x 10(-5), 1 x 10(-8) and 5 x 10(-5)M, respectively. bisphenol A 46-57 estrogen receptor 1 Homo sapiens 161-184 12818366-7 2003 4OHPB as well as diethylstilbestrol (DES) and bisphenol A (BPA), which are known xenoestrogenic compounds, competitively displaced 17beta-estradiol bound to the estrogen receptor alpha in a concentration-dependent manner; IC(50) values of these compounds were approximately 1 x 10(-5), 1 x 10(-8) and 5 x 10(-5)M, respectively. bisphenol A 59-62 estrogen receptor 1 Homo sapiens 161-184 12634121-1 2002 Estrogenic industrial compounds such as bisphenol A (BPA) and nonylphenol typically bind estrogen receptor (ER) alpha and ERBeta and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually greater than or equal to 1,000-fold lower than observed for 17Beta-estradiol. bisphenol A 40-51 estrogen receptor 1 Homo sapiens 89-117 12634121-1 2002 Estrogenic industrial compounds such as bisphenol A (BPA) and nonylphenol typically bind estrogen receptor (ER) alpha and ERBeta and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually greater than or equal to 1,000-fold lower than observed for 17Beta-estradiol. bisphenol A 53-56 estrogen receptor 1 Homo sapiens 89-117 12402979-3 2002 The estrogenic activities of BPA were detectable in all cell lines via both ERalpha and ERbeta. bisphenol A 29-32 estrogen receptor 1 Homo sapiens 76-83 12402979-4 2002 In 293T cells and Hec-1 cells, the estrogenic activities were significantly decreased when cells expressing ERalpha were incubated with 10(-6) M BPA in the presence of 10(-8) M 17beta-estradiol (E2) while the activities via ERbeta were essentially unchanged in the same conditions. bisphenol A 145-148 estrogen receptor 1 Homo sapiens 108-115 12402979-6 2002 Our results indicate that BPA only acts as an agonist of estrogen via ERbeta whereas it has dual actions as an agonist and antagonist in some types of cells via ERalpha. bisphenol A 26-29 estrogen receptor 1 Homo sapiens 161-168 11823001-5 2002 In another experiment, DHB and THB displaced competitively 17beta-estradiol bound to the recombinant human estrogen receptor alpha in a concentration-dependent manner: IC(50) of diethylstilbestrol and bisphenol A, which are known xenoestorogenic compounds, and DHB and THB was approximately 1 x 10(-8), 1 x 10(-5), 5 x 10(-5) and 5 x 10(-4) M, respectively. bisphenol A 201-212 estrogen receptor 1 Homo sapiens 107-130 11771854-0 2001 Bisphenol A enhances cadmium toxicity through estrogen receptor. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 46-63 11771854-6 2001 These findings suggest that BPA reduced hepatic MT synthesis after Cd injection via the estrogen receptor which resulted in increased damage to the liver. bisphenol A 28-31 estrogen receptor 1 Homo sapiens 88-105 11414046-4 2001 All of the peaks finally disappeared after 20 h. For the treated water, the transcriptional estrogenic activity in response to human estrogen receptor in a yeast hybrid assay decreased drastically to less than 1% of the initial BPA"s activity within 4 h. On the basis of these results, we conclude that TiO2 photocatalysis could be a useful technology for the purification of water containing BPA without generating any serious secondary pollution. bisphenol A 228-231 estrogen receptor 1 Homo sapiens 133-150 11414046-4 2001 All of the peaks finally disappeared after 20 h. For the treated water, the transcriptional estrogenic activity in response to human estrogen receptor in a yeast hybrid assay decreased drastically to less than 1% of the initial BPA"s activity within 4 h. On the basis of these results, we conclude that TiO2 photocatalysis could be a useful technology for the purification of water containing BPA without generating any serious secondary pollution. bisphenol A 393-396 estrogen receptor 1 Homo sapiens 133-150 11354909-2 2001 p-Hydroxybenzophenone as well as diethylstilbestrol and bisphenol A, known xeno-estrogenic compounds, competed with fluorescein-labeled 17 beta-estradiol to bind human recombinant ER alpha in a concentration-dependent manner. bisphenol A 56-67 estrogen receptor 1 Homo sapiens 180-188 11335189-9 2001 These results indicate that several pure PBDE congeners, but especially HO-PBDEs and brominated bisphenol A-analogs, are agonists of both ER alpha and ER beta receptors, thus stimulating ER-mediated luciferase induction in vitro. bisphenol A 96-107 estrogen receptor 1 Homo sapiens 138-146 11689155-8 2001 A comparison of the relative binding affinities of BPA for rat uterine estrogen receptor alpha to that of the Type II EBS implies that BPA preferentially binds to the Type II EBS. bisphenol A 51-54 estrogen receptor 1 Homo sapiens 71-94 11689155-8 2001 A comparison of the relative binding affinities of BPA for rat uterine estrogen receptor alpha to that of the Type II EBS implies that BPA preferentially binds to the Type II EBS. bisphenol A 135-138 estrogen receptor 1 Homo sapiens 71-94 11258963-9 2001 These results demonstrate that BPA competes more effectively for binding to ERbeta, but induces ERalpha- and ERbeta-mediated gene expression with comparable efficacy. bisphenol A 31-34 estrogen receptor 1 Homo sapiens 96-104 11800169-3 2001 Most estrogenic industrial compounds, such as bisphenol A (BPA) and nonylphenol, typically bind estrogen receptors alpha (ERalpha) and beta (ERbeta) and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually > or = 1,000-fold lower than observed for 17beta-estradiol (E2). bisphenol A 46-57 estrogen receptor 1 Homo sapiens 122-129 11800169-3 2001 Most estrogenic industrial compounds, such as bisphenol A (BPA) and nonylphenol, typically bind estrogen receptors alpha (ERalpha) and beta (ERbeta) and induce transactivation of estrogen-responsive genes/reporter genes, but their potencies are usually > or = 1,000-fold lower than observed for 17beta-estradiol (E2). bisphenol A 59-62 estrogen receptor 1 Homo sapiens 122-129 10854714-7 2000 In HepG2 cells cotreated with E2 plus the estrogenic compounds, only BPA and resveratrol exhibited ER(alpha) antagonist activity. bisphenol A 69-72 estrogen receptor 1 Homo sapiens 99-108 10724352-0 1999 Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. bisphenol A 29-40 estrogen receptor 1 Homo sapiens 67-90 10724352-0 1999 Differential interactions of bisphenol A and 17beta-estradiol with estrogen receptor alpha (ERalpha) and ERbeta. bisphenol A 29-40 estrogen receptor 1 Homo sapiens 92-99 10724352-3 1999 Estrogenic activity of BPA was detectable at a concentration of 10(-9) M and the activity increased in a dose dependent manner between concentrations of 10(-9) M and 10(-6) M of BPA for both ERalpha and ERbeta. bisphenol A 23-26 estrogen receptor 1 Homo sapiens 191-198 10724352-3 1999 Estrogenic activity of BPA was detectable at a concentration of 10(-9) M and the activity increased in a dose dependent manner between concentrations of 10(-9) M and 10(-6) M of BPA for both ERalpha and ERbeta. bisphenol A 178-181 estrogen receptor 1 Homo sapiens 191-198 10724352-4 1999 The estrogenic activity of 17beta-estradiol at a concentration of 10(-8) M was almost compatible with that of BPA at the concentration of 10(-6) M of BPA for ERalpha as well as ERbeta. bisphenol A 110-113 estrogen receptor 1 Homo sapiens 158-165 10724352-4 1999 The estrogenic activity of 17beta-estradiol at a concentration of 10(-8) M was almost compatible with that of BPA at the concentration of 10(-6) M of BPA for ERalpha as well as ERbeta. bisphenol A 150-153 estrogen receptor 1 Homo sapiens 158-165 10724352-5 1999 CAT activity was significantly decreased when cells expressing ERalpha were incubated with 10(-6) M of BPA and 10(-8) M of 17beta-estradiol while the activity was essentially the same for ERbeta in the same condition, indicating that BPA exhibits only agonistic action for ERbeta whereas it has dual actions as an agonist and antagonist of estrogen for ERalpha. bisphenol A 103-106 estrogen receptor 1 Homo sapiens 63-70 10724352-5 1999 CAT activity was significantly decreased when cells expressing ERalpha were incubated with 10(-6) M of BPA and 10(-8) M of 17beta-estradiol while the activity was essentially the same for ERbeta in the same condition, indicating that BPA exhibits only agonistic action for ERbeta whereas it has dual actions as an agonist and antagonist of estrogen for ERalpha. bisphenol A 103-106 estrogen receptor 1 Homo sapiens 353-360 10724352-5 1999 CAT activity was significantly decreased when cells expressing ERalpha were incubated with 10(-6) M of BPA and 10(-8) M of 17beta-estradiol while the activity was essentially the same for ERbeta in the same condition, indicating that BPA exhibits only agonistic action for ERbeta whereas it has dual actions as an agonist and antagonist of estrogen for ERalpha. bisphenol A 234-237 estrogen receptor 1 Homo sapiens 63-70 9783916-0 1998 Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 31-54 9783916-1 1998 We investigated the interaction of bisphenol A (BPA, an estrogenic environmental contaminant used in the manufacture of plastics) with the estrogen receptor alpha (ERalpha) transfected into the human HepG2 hepatoma cell line and expanded the study in vivo to examine the effect of BPA on the immature rat uterus. bisphenol A 35-46 estrogen receptor 1 Homo sapiens 139-162 9783916-1 1998 We investigated the interaction of bisphenol A (BPA, an estrogenic environmental contaminant used in the manufacture of plastics) with the estrogen receptor alpha (ERalpha) transfected into the human HepG2 hepatoma cell line and expanded the study in vivo to examine the effect of BPA on the immature rat uterus. bisphenol A 35-46 estrogen receptor 1 Homo sapiens 164-171 9783916-1 1998 We investigated the interaction of bisphenol A (BPA, an estrogenic environmental contaminant used in the manufacture of plastics) with the estrogen receptor alpha (ERalpha) transfected into the human HepG2 hepatoma cell line and expanded the study in vivo to examine the effect of BPA on the immature rat uterus. bisphenol A 48-51 estrogen receptor 1 Homo sapiens 139-162 9783916-1 1998 We investigated the interaction of bisphenol A (BPA, an estrogenic environmental contaminant used in the manufacture of plastics) with the estrogen receptor alpha (ERalpha) transfected into the human HepG2 hepatoma cell line and expanded the study in vivo to examine the effect of BPA on the immature rat uterus. bisphenol A 48-51 estrogen receptor 1 Homo sapiens 164-171 9783916-2 1998 Bisphenol A was 26-fold less potent in activating ER-WT and was a partial agonist with the ERalpha compared to E2. bisphenol A 0-11 estrogen receptor 1 Homo sapiens 91-98 9783916-8 1998 These results demonstrate that BPA is not merely a weak estrogen mimic but exhibits a distinct mechanism of action at the ERalpha. bisphenol A 31-34 estrogen receptor 1 Homo sapiens 122-129