PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12732287-1 2003 In human prostate cancer cells, the availability of the steroid hormone 1,25-dihydroxyvitamin D(3) for antimitotic action is determined through the activity of the two enzymes CYP24 and CYP27B1, viz. 1,25-dihydroxyvitamin D 72-95 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 186-193 34519274-1 2021 Low serum 1,25-dihydroxyvitamin D (1,25(OH)2D) in end stage renal disease (ESRD) is considered a consequence of elevated fibroblast growth factor 23 (FGF23) and concomitant reduced activity of renal 1alpha-hydroxylase (CYP27B1). 1,25-dihydroxyvitamin D 10-33 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 219-226 12386916-2 2002 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate. 1,25-dihydroxyvitamin D 146-169 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-42 12055341-2 2002 Bioactivation occurs through the sequential actions of cytochromes P450C25 and P450C1, resulting in synthesis of the pleiotropic hormone 1,25-dihydroxyvitamin D (1,25VD), which regulates over 60 genes whose actions include those associated with calcium homeostasis and immune responses as well as cellular growth, differentiation, and apoptosis. 1,25-dihydroxyvitamin D 137-160 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 79-85 11158062-1 2001 The mitochondrial enzyme 25-hydroxyvitamin D(3)-1 alpha-hydroxylase (1 alpha-hydroxylase) plays an important role in calcium homeostasis by catalyzing synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D(3), in the kidney. 1,25-dihydroxyvitamin D 194-217 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 25-67 10320521-1 1999 Pseudovitamin D-defiency rickets (PDDR) is an autosomal recessive disorder characterized by hypocalcemia, rickets (which are resistant to treatment with vitamin D), and low or undetectable serum levels of 1,25-dihydroxyvitamin D (1,25(OH)2D). 1,25-dihydroxyvitamin D 205-228 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 34-38 12899521-1 2003 The 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) is responsible for producing the active form of vitamin D, 1alpha,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D 111-139 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 22-36 12899521-1 2003 The 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) is responsible for producing the active form of vitamin D, 1alpha,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D 111-139 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 24-36 27473561-3 2017 The 1alpha-hydroxylation of 25(OH)D in the kidney by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)2D). 1,25-dihydroxyvitamin D 110-133 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 53-60 31805709-1 2019 The protein 1alpha-hydroxylase (CYP27B1) was expressed in liver and omega-3 fatty acid (FA) elevated 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in dialysis patients. 1,25-dihydroxyvitamin D 101-124 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 32-39 29116467-2 2018 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, is known to inhibit expression of CYP27B1, which is very similar in structure and function to CYP27A1, the synthesizing enzyme of 27HC. 1,25-dihydroxyvitamin D 0-23 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 108-115 35482362-8 2022 The next hydroxylation step occurs in the renal proximal tubule via the 1-alphahydroxylase enzyme (encoded by CYP27B1) thereby generating 1,25-dihydroxyvitamin D, that is, calcitriol. 1,25-dihydroxyvitamin D 138-161 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 110-117 32351560-1 2020 Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. 1,25-dihydroxyvitamin D 188-211 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 100-107 28768705-2 2017 In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1. 1,25-dihydroxyvitamin D 94-117 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 121-128 25716808-2 2015 Various kinds of immune cells-including macrophages, dendritic cells, T cells and B cells- express the vitamin D receptor and 1alpha-hydroxylase (CYP27B1), the enzyme necessary for the conversion of circulating 25-hydroxyvitamin D into its active form, 1,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D 253-276 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 146-153 29074823-4 2017 The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D]. 1,25-dihydroxyvitamin D 189-212 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 129-136 27287609-0 2017 A Case of Vitamin-D-Dependent Rickets Type 1A with Normal 1,25-Dihydroxyvitamin D Caused by Two Novel Mutations of the CYP27B1 Gene. 1,25-dihydroxyvitamin D 58-81 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 119-126 27403416-4 2016 The active form of vitamin D, 1,25-dihydroxyvitamin D (calcitriol), is biosynthesised in the kidney through the hydroxylation of 25-hydroxycholecalciferol by the CYP27B1 enzyme. 1,25-dihydroxyvitamin D 30-53 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 162-169 22989482-1 2013 Human marrow stromal cells (hMSCs) are targets of 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D3] action to promote their differentiation to osteoblasts, but they also participate in vitamin D metabolism by converting 25-dihydroxyvitamin D3 [25(OH)D3] to 1alpha,25(OH)2D3 by 1alpha-hydroxylase (CYP27B1). 1,25-dihydroxyvitamin D 50-78 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 295-302 25060765-2 2015 The CYP27B1 gene, which encodes the 1-alpha-hidroxylase and involved in the 1,25-dihydroxyvitamin D synthesis, was recently associated to type-1 diabetes, autoimmune disorders and treatment response in HCV. 1,25-dihydroxyvitamin D 76-99 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 4-11 24120913-1 2014 The metabolism of 25-hydroxyvitamin D (25D) to active 1alpha,25-dihydroxyvitamin D (1,25D) by endogenous expression of 25D 1-alpha hydroxylase (CYP27B1) in bone cells appears to have functional effects in both osteoclasts and osteoblasts. 1,25-dihydroxyvitamin D 54-82 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 144-151 24471562-7 2014 MAIN OUTCOMES: Protein and mRNA expressions of CYP27B1, CYP24A1, and vitamin D receptor were measured in term placental tissue and related to 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, PTH, serum total calcium, IL-6, leptin, and osteoprotegerin measured in maternal serum at midgestation and delivery and in umbilical cord serum at birth. 1,25-dihydroxyvitamin D 173-196 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 47-54 24471562-9 2014 Maternal serum 1,25-dihydroxyvitamin D concentrations at midgestation were positively correlated with term placental CYP27B1 mRNA expression (n = 49, P = .002). 1,25-dihydroxyvitamin D 15-38 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 117-124 22107948-2 2012 Classically, hormonal 1,25-dihydroxyvitamin D (1,25D), produced in the kidney by CYP27B1-catalyzed 1alpha-hydroxylation from its circulating 25-hydroxy precursor, has been considered to function as a critical endocrine regulator of calcium homeostasis. 1,25-dihydroxyvitamin D 22-45 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 81-88 22446158-2 2012 This expression profile establishes the potential for interaction of the VDR with the product of the CYP27B1, 1,25-dihydroxyvitamin D (1,25-(OH)(2)D), in either an intracrine or paracrine mode. 1,25-dihydroxyvitamin D 110-133 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 101-108 23423976-2 2013 Its chief circulating metabolite, 25-hydroxyvitamin D, is converted into the active hormone 1,25-dihydroxyvitamin D (1,25D) by the cytochrome P450 enzyme CYP27B1 in kidney and other tissues. 1,25-dihydroxyvitamin D 92-115 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 154-161 21845364-2 2012 Vitamin D was originally characterized for its role in calcium homeostasis, and the active form, 1,25-dihydroxyvitamin D (1,25D), can be produced in the kidney by 1alpha-hydroxylation of circulating 25-hydroxyvitamin D catalyzed by the enzyme CYP27B1. 1,25-dihydroxyvitamin D 97-120 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 243-250 22544628-1 2012 All cells comprising the skeleton-chondrocytes, osteoblasts, and osteoclasts-contain both the vitamin D receptor and the enzyme CYP27B1 required for producing the active metabolite of vitamin D, 1,25 dihydroxyvitamin D. 1,25-dihydroxyvitamin D 195-218 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 128-135 21932165-1 2012 1,25-dihydroxyvitamin D (1,25D), through association with the nuclear vitamin D receptor (VDR), exerts control over a novel endocrine axis consisting of the bone-derived hormone FGF23, and the kidney-expressed klotho, CYP27B1, and CYP24A1 genes, which together prevent hyperphosphatemia/ectopic calcification and govern the levels of 1,25D to maintain bone mineral integrity while promoting optimal function of other vital tissues. 1,25-dihydroxyvitamin D 0-23 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 218-225 20605845-2 2010 Vitamin D is modified in the liver and the kidney to its active form (1,25-dihydroxyvitamin D) by the 25-hydroxy vitamin D 1-hydroxylase enzyme (CYP27B1). 1,25-dihydroxyvitamin D 70-93 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 145-152 23171504-1 2012 BACKGROUND: Local production of 1,25-dihydroxyvitamin D (1,25(OH)(2)D) regulated by the CYP27B1 enzyme in monocytes contributes to the immunomodulatory effects of vitamin D. 1,25-dihydroxyvitamin D 32-55 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 88-95 17079137-1 2007 Human placenta synthesizes and metabolizes 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)/calcitriol] through the activity of 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1) and 1,25(OH)(2)D(3)-24-hydroxylase (CYP24A1), the two key enzymes for Vitamin D metabolism. 1,25-dihydroxyvitamin D 43-66 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 123-164 19944755-8 2010 The synergistic effect of 25-hydroxyvitamin D(3) with 1alpha,25-dihydroxyvitamin D(3) in Cyp27b1(-/-) cells further demonstrates the agonistic action of 25-hydroxyvitamin D(3) and suggests that a synergism between 25-hydroxyvitamin D(3) and 1alpha,25-dihydroxyvitamin D(3) might be physiologically important. 1,25-dihydroxyvitamin D 54-82 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 89-96 19966181-2 2010 Extrarenal conversion of 25-hydroxyvitamin D (25OHD) to the biologically active form of vitamin D, 1 alpha,25-dihydroxyvitamin D [1,25(OH)(2)D] is catalyzed in several cell types by the 1 alpha-hydroxylase (CYP27B1), but little is known about the expression or regulation of CYP27B1 in human bones. 1,25-dihydroxyvitamin D 99-128 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 207-214 19966181-2 2010 Extrarenal conversion of 25-hydroxyvitamin D (25OHD) to the biologically active form of vitamin D, 1 alpha,25-dihydroxyvitamin D [1,25(OH)(2)D] is catalyzed in several cell types by the 1 alpha-hydroxylase (CYP27B1), but little is known about the expression or regulation of CYP27B1 in human bones. 1,25-dihydroxyvitamin D 99-128 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 275-282 18767934-1 2009 CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, converts 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D, and is expressed primarily in the kidney but also in nontraditional sites including the parathyroid glands. 1,25-dihydroxyvitamin D 107-130 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 17395559-1 2007 Circulating 1 alpha,25-dihydroxyvitamin D(3) (1,25D) derives from renal conversion of 25-hydroxyvitamin D(3) (25D), by the 25D 1 alpha-hydroxylase (CYP27B1). 1,25-dihydroxyvitamin D 12-41 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 148-155 19524013-1 2009 Synthesis of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is catalysed by the enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1). 1,25-dihydroxyvitamin D 13-36 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 85-126 19524013-1 2009 Synthesis of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is catalysed by the enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1). 1,25-dihydroxyvitamin D 13-36 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 128-135 19667164-3 2009 Vitamin D metabolism poses unique problems for the regulation of 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations in the tissues outside the kidney that possess 25(OH)D-1-hydroxylase [CYP27B1] and the catabolic enzyme, 1,25(OH)2D-24-hydroxylase [CYP24]. 1,25-dihydroxyvitamin D 65-88 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 187-194 18290716-1 2007 Tissue availability of the active vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] is dependent on expression of the activating enzyme 1alpha-hydroxylase (CYP27b1) and its catabolic counterpart 24-hydroxylase (CYP24). 1,25-dihydroxyvitamin D 56-79 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 167-174 17079137-1 2007 Human placenta synthesizes and metabolizes 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)/calcitriol] through the activity of 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1) and 1,25(OH)(2)D(3)-24-hydroxylase (CYP24A1), the two key enzymes for Vitamin D metabolism. 1,25-dihydroxyvitamin D 43-66 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 166-173 12914530-1 2003 Critical to an understanding of the control of 1,25-dihydroxyvitamin D (1,25D) activity is a molecular appreciation of the regulation of three genes, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1), 25-hydroxyvitamin D-24-hydroxylase (CYP24) and vitamin D receptor (VDR). 1,25-dihydroxyvitamin D 47-70 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 190-197 16081282-2 2005 The antimitotic, prodifferentiating and proapoptotic active metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25-(OH)(2)-D(3)) is synthesized also by colonocytes, since these possess Vitamin D synthesizing (CYP27B1) and catabolic (CYP24) hydroxylases similar to the kidney. 1,25-dihydroxyvitamin D 71-99 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 203-210 15691891-1 2005 The enzyme 25-hydroxyvitamin D 1alpha-hydroxylase, or CYP27B1, is the key enzyme in the two-step activation process of vitamin D to 1,25-dihydroxyvitamin D (1,25D). 1,25-dihydroxyvitamin D 132-155 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 54-61 15223133-1 2004 Vitamin D 1alpha-hydroxylase (1alpha(OH)ase), which converts the circulating prohormone 25-hydroxyvitamin-D(3) (25(OH)D(3)) to the active 1alpha-25-dihydroxyvitamin-D(3) (1,25(OH)(2)D(3)), is present in normal prostatic epithelium. 1,25-dihydroxyvitamin D 138-166 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 30-43