PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12706339-6	2003	In taurine-supplemented rats bile flow was 30% higher than that in untreated rats and the expression of Mrp2 and Bsep protein was increased two- to threefold.	Taurine	3-10	ATP binding cassette subfamily B member 4	Rattus norvegicus	104-108	
12706339-0	2003	Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis.	Taurine	0-7	ATP binding cassette subfamily B member 4	Rattus norvegicus	32-62	
12706339-8	2003	This protective effect of taurine was due to higher Mrp2 and Bsep protein levels compared to nonsupplemented LPS-treated rats, whereas relative Mrp2 retrieval from the canalicular membrane induced by LPS was not significantly different.	Taurine	26-33	ATP binding cassette subfamily B member 4	Rattus norvegicus	52-56	
12706339-9	2003	LPS-induced tumor necrosis factor alpha and interleukin-1beta release were lower in taurine-fed rats; however, downregulation of Mrp2 and Bsep expression by LPS was delayed but not prevented.	Taurine	84-91	ATP binding cassette subfamily B member 4	Rattus norvegicus	129-133	
12706339-10	2003	The data show that oral supplementation of taurine induces Mrp2 and Bsep expression and may prevent LPS-induced cholestasis.	Taurine	43-50	ATP binding cassette subfamily B member 4	Rattus norvegicus	59-63	
11546558-4	2001	In our previous study, the contribution of multidrug resistance protein 2 for biliary excretion of taurine-conjugated bile acid sulfates depended on the numbers of hydroxyl residue.	Taurine	99-106	ATP binding cassette subfamily B member 4	Rattus norvegicus	43-73	
11546558-5	2001	Therefore, to further examine the effect of hydrophobicity on the substrate specificity of multidrug resistance protein 2, we examined the effect of bile acid conjugates and organic anions on biliary excretion of tauroursodeoxycholate-3-sulfate, taurine and sulfonate-conjugated ursodeoxycholic acid, in rats.	Taurine	246-253	ATP binding cassette subfamily B member 4	Rattus norvegicus	91-121	
10577837-3	1999	Therefore, to examine the effect of hydrophobicity on the substrate specificity of canalicular multispecific organic anion transporter/multidrug resistance protein 2, we examined the effect of organic anions and bile acid conjugates on biliary excretion of three taurine-conjugated bile acid sulfates with different hydrophobicity, taurolithocholate-3-sulfate, taurochenodeoxycholate3-sulfate, and taurocholate-3-sulfate in rats.	Taurine	263-270	ATP binding cassette subfamily B member 4	Rattus norvegicus	135-165	
10915741-5	2000	Under optimal culture conditions, taurine-conjugated bile acids (50 micromol/L) increased mdr2 messenger RNA (mRNA) levels in the following order: taurocholate (TCA) (288 +/- 36%, P <.	Taurine	34-41	ATP binding cassette subfamily B member 4	Rattus norvegicus	90-94