PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33658385-2	2021	Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B4 (LTB4).	Dexamethasone	0-13	leukotriene A4 hydrolase	Homo sapiens	62-86	
25799317-1	2015	Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient"s LTA4H genotype.	Dexamethasone	11-24	leukotriene A4 hydrolase	Homo sapiens	129-134	
33658385-2	2021	Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B4 (LTB4).	Dexamethasone	0-13	leukotriene A4 hydrolase	Homo sapiens	88-93	
33658385-3	2021	TT homozygotes, with increased expression of LTA4H, have the highest survival when treated with dexamethasone and the lowest survival without.	Dexamethasone	96-109	leukotriene A4 hydrolase	Homo sapiens	45-50	
30169607-2	2019	We analyzed cerebrospinal fluid (CSF) cytokine concentrations from participants over the first week of treatment to investigate mechanisms of harm and test 2 hypotheses: (1) dexamethasone reduced proinflammatory cytokine concentrations, leading to poorer outcomes and (2) leukotriene A4 hydrolase (LTA4H) genotype influenced the clinical impact of dexamethasone, as observed in tuberculous meningitis.	Dexamethasone	174-187	leukotriene A4 hydrolase	Homo sapiens	272-296	
30169607-2	2019	We analyzed cerebrospinal fluid (CSF) cytokine concentrations from participants over the first week of treatment to investigate mechanisms of harm and test 2 hypotheses: (1) dexamethasone reduced proinflammatory cytokine concentrations, leading to poorer outcomes and (2) leukotriene A4 hydrolase (LTA4H) genotype influenced the clinical impact of dexamethasone, as observed in tuberculous meningitis.	Dexamethasone	174-187	leukotriene A4 hydrolase	Homo sapiens	298-303	
30363837-2	2018	In tuberculous meningitis (TBM), a common functional promoter variant (C/T transition) in the gene encoding leukotriene A4 hydrolase (LTA4H), predicts pre-treatment inflammatory phenotype and response to dexamethasone in HIV-uninfected individuals.	Dexamethasone	204-217	leukotriene A4 hydrolase	Homo sapiens	108-132	
30363837-2	2018	In tuberculous meningitis (TBM), a common functional promoter variant (C/T transition) in the gene encoding leukotriene A4 hydrolase (LTA4H), predicts pre-treatment inflammatory phenotype and response to dexamethasone in HIV-uninfected individuals.	Dexamethasone	204-217	leukotriene A4 hydrolase	Homo sapiens	134-139	
30363837-12	2018	We will stratify dexamethasone therapy according to LTA4H genotype in HIV-uninfected adults, which may indicate a role for targeted anti-inflammatory therapy according to variation in LTA4H C/T transition.	Dexamethasone	17-30	leukotriene A4 hydrolase	Homo sapiens	52-57