PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11593406-2	2001	IL-6 also confers protection against Dexamethasone (Dex)-induced apoptosis via activation of protein tyrosine phosphatase (SHP2).	Dexamethasone	37-50	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	123-127	
19139110-8	2009	INCB20 also abrogated the protective effect of IL-6 against dexamethasone by blocking phosphorylation of SHP-2 and AKT.	Dexamethasone	60-73	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	105-110	
11593406-2	2001	IL-6 also confers protection against Dexamethasone (Dex)-induced apoptosis via activation of protein tyrosine phosphatase (SHP2).	Dexamethasone	37-40	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	123-127	
11593406-7	2001	We demonstrate that Dex-induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9, with resultant caspase-3 cleavage; and conversely, that IL-6 triggers activation of PI3-K and its association with SHP2, inactivates caspase-9, and protects against Dex-induced apoptosis.	Dexamethasone	20-23	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	223-227	
21946312-4	2011	We found that DEX suppressed Shp2 interaction with TrkB, a receptor for BDNF, in cultured cortical neurons.	Dexamethasone	14-17	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	29-33	
10880513-0	2000	SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.	Dexamethasone	61-74	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	0-4	
10880513-4	2000	We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.	Dexamethasone	90-93	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	51-55	
10880513-7	2000	Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.	Dexamethasone	97-100	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	46-50	
32246174-8	2020	In addition, co-treatment of PD-1 + Jurkat cells with prednisone and/or dexamethasone with anti-PD-1 before stimulation significantly reduced SHP-2 phosphorylation, indicative of increased T cell function.	Dexamethasone	72-85	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	142-147	
21946312-5	2011	NSC87877, a Shp2 inhibitor, mimicked DEX, and Shp2 overexpression reversed the effect of DEX, suggesting that GCs suppress ERK signaling through inhibiting the interaction of Shp2 with TrkB.	Dexamethasone	89-92	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	46-50	
21946312-5	2011	NSC87877, a Shp2 inhibitor, mimicked DEX, and Shp2 overexpression reversed the effect of DEX, suggesting that GCs suppress ERK signaling through inhibiting the interaction of Shp2 with TrkB.	Dexamethasone	89-92	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	46-50