PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9169415-9 1997 Interestingly, whereas receptor-activated STAT3 also enhances stimulation of the haptoglobin promoter by dexamethasone through the glucocorticoid receptor, activated STAT3Delta55C reduces the regulation below the level achieved by the glucocorticoid receptor alone. Dexamethasone 105-118 signal transducer and activator of transcription 3 Mus musculus 42-47 20881248-5 2010 Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. Dexamethasone 51-64 signal transducer and activator of transcription 3 Mus musculus 92-97 34175886-0 2021 Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways. Dexamethasone 0-13 signal transducer and activator of transcription 3 Mus musculus 55-60 34175886-12 2021 Mechanism study shows dexamethasone mediated transcriptional suppression of PD-L1 and IDO1 depends on the nuclear translocation of GR/STAT3 complex. Dexamethasone 22-35 signal transducer and activator of transcription 3 Mus musculus 134-139 34175886-13 2021 These findings demonstrate dexamethasone can suppress immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways. Dexamethasone 27-40 signal transducer and activator of transcription 3 Mus musculus 84-89 23871159-0 2013 Interleukin-6 and JAK2/STAT3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7TD1 multiple myeloma cells. Dexamethasone 64-77 signal transducer and activator of transcription 3 Mus musculus 23-28 23871159-0 2013 Interleukin-6 and JAK2/STAT3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7TD1 multiple myeloma cells. Dexamethasone 95-108 signal transducer and activator of transcription 3 Mus musculus 23-28 23871159-4 2013 Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon. Dexamethasone 66-69 signal transducer and activator of transcription 3 Mus musculus 110-115 23871159-4 2013 Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon. Dexamethasone 66-69 signal transducer and activator of transcription 3 Mus musculus 110-115 35255002-9 2022 As a mechanism of Dex-induced SOX2 upregulation in preosteoblasts, we found that the STAT3 pathway or GC receptor (GR) is involved using a GR antagonist, STAT3 regulators, and chromatin immunoprecipitation assays. Dexamethasone 18-21 signal transducer and activator of transcription 3 Mus musculus 85-90 25563207-5 2015 Pre-treatment of DEX or SB203580 inhibited lipopolysaccharide (LPS)-stimulated IL-10, TNF-alpha secretion, and STAT3 phosphorylation. Dexamethasone 17-20 signal transducer and activator of transcription 3 Mus musculus 111-116 25563207-7 2015 Combining DEX and SB203580 showed strong inhibition on the LPS-induced IL-10 secretion and STAT3 phosphorylation, which might reflect a very important drawback from the combined use of both anti-inflammatory agents. Dexamethasone 10-13 signal transducer and activator of transcription 3 Mus musculus 91-96 24992071-11 2014 Collectively, our results demonstrate potent anti-angiogenic, and selective JAK3/STAT3 down-regulating anticancer characteristics of DX8, a new dexamethasone-based antitumor molecule. Dexamethasone 144-157 signal transducer and activator of transcription 3 Mus musculus 81-86 23688998-0 2013 [Effect of dexamethasone on expression of interleukin-21 and phospho-STAT3 in a murine model of chronic asthma]. Dexamethasone 11-24 signal transducer and activator of transcription 3 Mus musculus 69-74 23688998-1 2013 OBJECTIVE: To investigate the effects of dexamethasone on the expression of interleukin-21 (IL-21) and phospho- STAT3 (p-STAT3) in a murine model of chronic asthma. Dexamethasone 41-54 signal transducer and activator of transcription 3 Mus musculus 112-117 23688998-1 2013 OBJECTIVE: To investigate the effects of dexamethasone on the expression of interleukin-21 (IL-21) and phospho- STAT3 (p-STAT3) in a murine model of chronic asthma. Dexamethasone 41-54 signal transducer and activator of transcription 3 Mus musculus 121-126 23688998-7 2013 Compared with the control group, the asthmatic group showed significantly increased protein expressions of IL-21 and p-STAT3 (P<0.05), which were reduced by dexamethasone intervention (P/0.05). Dexamethasone 160-173 signal transducer and activator of transcription 3 Mus musculus 119-124 23688998-8 2013 CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma. Dexamethasone 12-25 signal transducer and activator of transcription 3 Mus musculus 68-73 23688998-8 2013 CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma. Dexamethasone 12-25 signal transducer and activator of transcription 3 Mus musculus 148-153 23688998-8 2013 CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma. Dexamethasone 205-218 signal transducer and activator of transcription 3 Mus musculus 68-73 23688998-8 2013 CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma. Dexamethasone 205-218 signal transducer and activator of transcription 3 Mus musculus 148-153 20881248-5 2010 Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling. Dexamethasone 66-69 signal transducer and activator of transcription 3 Mus musculus 92-97 20881248-8 2010 Moreover, DEX administration delayed STAT3 activation and translocation into epithelial cells nuclei. Dexamethasone 10-13 signal transducer and activator of transcription 3 Mus musculus 37-42 20881248-9 2010 In particular, DEX treatment impaired the increment in gene expression of signal transducer subunit gp130, normally up-regulated from lactation to involution and responsible for STAT3 activation. Dexamethasone 15-18 signal transducer and activator of transcription 3 Mus musculus 178-183 17204554-4 2007 Here we determined that the adipocyte differentiation cocktail containing isobutylmethylxanthine, dexamethasone, and insulin (MDI) induced STAT3 tyrosine phosphorylation indirectly through the synthesis of an autocrine/paracrine factor. Dexamethasone 98-111 signal transducer and activator of transcription 3 Mus musculus 139-144 21073728-9 2010 STAT3 activation followed paw swelling and cytokine levels in both models and correlates of disease could be ablated upon treatment with dexamethasone. Dexamethasone 137-150 signal transducer and activator of transcription 3 Mus musculus 0-5 20039267-0 2010 Bone morphogenetic protein 2 and dexamethasone synergistically increase alkaline phosphatase levels through JAK/STAT signaling in C3H10T1/2 cells. Dexamethasone 33-46 signal transducer and activator of transcription 3 Mus musculus 112-116 20039267-7 2010 A luciferase assay using ALP promoter deletion constructs showed that a region of the promoter containing a putative signal transducer and activator of transcription 3 (STAT3) response element (SRE) responds to treatment with a combination of BMP-2 and Dex. Dexamethasone 253-256 signal transducer and activator of transcription 3 Mus musculus 117-167 20039267-7 2010 A luciferase assay using ALP promoter deletion constructs showed that a region of the promoter containing a putative signal transducer and activator of transcription 3 (STAT3) response element (SRE) responds to treatment with a combination of BMP-2 and Dex. Dexamethasone 253-256 signal transducer and activator of transcription 3 Mus musculus 169-174 20039267-9 2010 In addition, a STAT3 siRNA suppressed the synergistic effect of BMP-2 and Dex on ALP levels. Dexamethasone 74-77 signal transducer and activator of transcription 3 Mus musculus 15-20 20039267-11 2010 To our knowledge, this is the first time that STAT3 has been implicated in the regulation of ALP expression by BMP-2 and Dex. Dexamethasone 121-124 signal transducer and activator of transcription 3 Mus musculus 46-51 18819004-6 2008 Our results suggest a role of entities downstream of IL6-mediated JAK/STAT3 signaling in development of dexamethasone resistance by 7TD1-Dxm cells. Dexamethasone 104-117 signal transducer and activator of transcription 3 Mus musculus 70-75 18819004-6 2008 Our results suggest a role of entities downstream of IL6-mediated JAK/STAT3 signaling in development of dexamethasone resistance by 7TD1-Dxm cells. Dexamethasone 137-140 signal transducer and activator of transcription 3 Mus musculus 70-75 14697342-7 2004 The combined treatment of dexamethasone and oncostatin M (OSM) enhanced the expression of the acute phase proteins in B13 cells and the mechanism of the up-regulation by the cytokine is probably mediated by phosphorylation of STAT3 and STAT1. Dexamethasone 26-39 signal transducer and activator of transcription 3 Mus musculus 226-231