PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30628712-0 2019 Dexamethasone protects against arsanilic acid-induced rat vestibular dysfunction through the BDNF and JNK 1/2 signaling pathways. Dexamethasone 0-13 mitogen-activated protein kinase 8 Rattus norvegicus 102-105 33190410-5 2021 Dexamethasone (Dex) was used to induce apoptosis in osteoblasts, and this resulted in a significant increase in levels of p-JNK, p-c-Jun, Bax, caspase-3, caspase-9, cytochrome C, Beclin-1, and LC3, and a decrease in levels of P62 and Bcl-2. Dexamethasone 0-13 mitogen-activated protein kinase 8 Rattus norvegicus 124-127 30628712-9 2019 In conclusion, DXMS was identified as a therapeutic agent targeting the BDNF and JNK singling pathways for AA-induced rat vestibular dysfunction. Dexamethasone 15-19 mitogen-activated protein kinase 8 Rattus norvegicus 81-84 17621647-4 2007 Similarly, the age-related increases in activation of the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), as well as caspase-3 and PARP were all attenuated in hippocampal tissue prepared from rats that received dexamethasone and vitamin D3. Dexamethasone 227-240 mitogen-activated protein kinase 8 Rattus norvegicus 116-119 25268311-12 2015 CONCLUSION: The insulin-resistant status of rats induced by dexamethasone administration have PKB and IRS-1 activity attenuated in epididymal fat without increases in the phosphorylation of the proinflammatory signals JNK and IKKbeta. Dexamethasone 60-73 mitogen-activated protein kinase 8 Rattus norvegicus 218-221 17621647-6 2007 In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the IL-1beta-induced increases in activation of JNK and caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3. Dexamethasone 119-132 mitogen-activated protein kinase 8 Rattus norvegicus 282-285 17621647-4 2007 Similarly, the age-related increases in activation of the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), as well as caspase-3 and PARP were all attenuated in hippocampal tissue prepared from rats that received dexamethasone and vitamin D3. Dexamethasone 227-240 mitogen-activated protein kinase 8 Rattus norvegicus 91-114 17403137-0 2007 Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia. Dexamethasone 0-13 mitogen-activated protein kinase 8 Rattus norvegicus 146-167 17403137-5 2007 It has been demonstrated that Dex inhibited the phosphorylation of Jun N-terminal kinase (JNK) and p38 MAP kinases as well as c-jun, the JNK substrate in microglia treated with LPS. Dexamethasone 30-33 mitogen-activated protein kinase 8 Rattus norvegicus 67-88 17403137-5 2007 It has been demonstrated that Dex inhibited the phosphorylation of Jun N-terminal kinase (JNK) and p38 MAP kinases as well as c-jun, the JNK substrate in microglia treated with LPS. Dexamethasone 30-33 mitogen-activated protein kinase 8 Rattus norvegicus 90-93 17403137-5 2007 It has been demonstrated that Dex inhibited the phosphorylation of Jun N-terminal kinase (JNK) and p38 MAP kinases as well as c-jun, the JNK substrate in microglia treated with LPS. Dexamethasone 30-33 mitogen-activated protein kinase 8 Rattus norvegicus 137-140 17403137-7 2007 In addition, Dex induced the expression of MAP kinase phosphatase-1 (MKP-1), the negative regulator of JNK and p38 MAP kinases in microglial cells exposed to LPS. Dexamethasone 13-16 mitogen-activated protein kinase 8 Rattus norvegicus 103-106 17403137-9 2007 In summary, Dex inhibits the MCP-1 production and subsequent microglial cells migration to the inflammatory site by regulating MKP-1 expression and the p38 and JNK MAPK pathways. Dexamethasone 12-15 mitogen-activated protein kinase 8 Rattus norvegicus 160-163 10702272-8 2000 Interestingly, the counterpart of Raf-1 in the c-Jun N-terminal kinase (JNK) cascade, MEKK-1 (mitogen-activated protein kinase/ERK kinase), is similarly associated with Hsp90, and this association as well as the activation of MEKK-1 are disrupted by dexamethasone treatment. Dexamethasone 250-263 mitogen-activated protein kinase 8 Rattus norvegicus 72-75 10702272-9 2000 Disruption of the ERK and JNK cascades at the level of Raf-1 and MEKK-1 could account for the inhibitory action of dexamethasone on the generation of inflammatory mediators in stimulated mast cells. Dexamethasone 115-128 mitogen-activated protein kinase 8 Rattus norvegicus 26-29 10051489-1 1999 The effect of dexamethasone on Jun N-terminal kinase (JNK) activity was assayed by using fetal hepatocytes in primary culture. Dexamethasone 14-27 mitogen-activated protein kinase 8 Rattus norvegicus 31-52 10051489-1 1999 The effect of dexamethasone on Jun N-terminal kinase (JNK) activity was assayed by using fetal hepatocytes in primary culture. Dexamethasone 14-27 mitogen-activated protein kinase 8 Rattus norvegicus 54-57 10051489-3 1999 We show that activation of JNK by this extracellular signal is inhibited by dexamethasone in a dose-dependent fashion. Dexamethasone 76-89 mitogen-activated protein kinase 8 Rattus norvegicus 27-30 10051489-7 1999 In addition, dexamethasone inhibits JNK phosphorylation induced by TNF-alpha. Dexamethasone 13-26 mitogen-activated protein kinase 8 Rattus norvegicus 36-39 14623117-3 2003 In a cell-free system, the phosphorylation of glutathione S-transferase-fused c-Jun by recombinant JNK was not inhibited by dexamethasone but was inhibited by the addition of recombinant glucocorticoid receptor (GR). Dexamethasone 124-137 mitogen-activated protein kinase 8 Rattus norvegicus 99-102 14623117-4 2003 These findings suggest that the inhibition of antigen-induced IL-13 production by dexamethasone is due to the GR-mediated inhibition of c-Jun phosphorylation induced by JNK. Dexamethasone 82-95 mitogen-activated protein kinase 8 Rattus norvegicus 169-172 9794429-0 1998 Inhibition by dexamethasone of antigen-induced c-Jun N-terminal kinase activation in rat basophilic leukemia cells. Dexamethasone 14-27 mitogen-activated protein kinase 8 Rattus norvegicus 47-70 9794429-4 1998 Pretreatment with dexamethasone (10 and 100 nM) for 18 h inhibited the Ag-induced increase in JNK activity in a concentration-dependent manner. Dexamethasone 18-31 mitogen-activated protein kinase 8 Rattus norvegicus 94-97 9794429-5 1998 At least 6 h of preincubation with dexamethasone was necessary to inhibit the Ag-induced JNK activation. Dexamethasone 35-48 mitogen-activated protein kinase 8 Rattus norvegicus 89-92 9794429-7 1998 The Ag-induced activation of the JNK kinase kinase mitogen-activated protein kinase-extracellular signal-regulated kinase kinase-1 was also inhibited by pretreatment with dexamethasone at 10 and 100 nM. Dexamethasone 171-184 mitogen-activated protein kinase 8 Rattus norvegicus 33-36 9794429-8 1998 These findings indicate that dexamethasone reduces JNK protein level and inhibits the Ag-induced activation of JNK resulting in the inhibition of c-Jun phosphorylation. Dexamethasone 29-42 mitogen-activated protein kinase 8 Rattus norvegicus 51-54 9794429-8 1998 These findings indicate that dexamethasone reduces JNK protein level and inhibits the Ag-induced activation of JNK resulting in the inhibition of c-Jun phosphorylation. Dexamethasone 29-42 mitogen-activated protein kinase 8 Rattus norvegicus 111-114