PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16176557-8 2005 These results suggest that clodronate and/or dexamethasone may be suitable for preventing or reducing the inflammatory side effects of nitrogen-containing bisphosphonates while preserving their powerful anti-bone-resorptive activities (although in practice the known side effects of dexamethasone may limit its use), and that the anti-bone resorptive activities of nitrogen-containing bisphosphonates are not influenced by IL-1. Dexamethasone 45-58 interleukin 1 complex Mus musculus 423-427 19572781-7 2009 A single intraperitoneal injection of dexamethasone (10 mg/kg body weight) 1 hour after melphalan exposure significantly reduced interleukin (IL)-1 and IL-6 in bronchoalveolar lavage fluid (BALF) and diminished the acute airway inflammation. Dexamethasone 38-51 interleukin 1 complex Mus musculus 129-147 10597915-8 1999 Pre-treatment of C3H/HeJ mice with dexamethasone reduced basal and induced IL-1 levels, but complete inhibition was not achieved. Dexamethasone 35-48 interleukin 1 complex Mus musculus 75-79 14754758-6 2004 Inhalation of dexamethasone, an inhibitor of IL-1 production, blocked the development of AHR, BAL fluid neutrophilia, and decreased levels of IL-1 following O(3) exposure. Dexamethasone 14-27 interleukin 1 complex Mus musculus 45-49 14754758-6 2004 Inhalation of dexamethasone, an inhibitor of IL-1 production, blocked the development of AHR, BAL fluid neutrophilia, and decreased levels of IL-1 following O(3) exposure. Dexamethasone 14-27 interleukin 1 complex Mus musculus 142-146 11158262-0 2001 Dexamethasone up-regulates type II IL-1 receptor in mouse primary activated astrocytes. Dexamethasone 0-13 interleukin 1 complex Mus musculus 35-39 11158262-4 2001 IL-1beta-activated mouse primary astrocytes were treated with 10(-6) M dexamethasone, and IL-1 receptors were studied at the mRNA and protein levels. Dexamethasone 71-84 interleukin 1 complex Mus musculus 0-4 11201166-10 2001 When hepatocytes were pretreated with dexamethasone (Dex) and IL-6, the activation of IRAK was augmented in response to IL-1, indicating that IL-1 signaling is also up-regulated. Dexamethasone 38-51 interleukin 1 complex Mus musculus 120-124 11201166-10 2001 When hepatocytes were pretreated with dexamethasone (Dex) and IL-6, the activation of IRAK was augmented in response to IL-1, indicating that IL-1 signaling is also up-regulated. Dexamethasone 38-51 interleukin 1 complex Mus musculus 142-146 11201166-10 2001 When hepatocytes were pretreated with dexamethasone (Dex) and IL-6, the activation of IRAK was augmented in response to IL-1, indicating that IL-1 signaling is also up-regulated. Dexamethasone 53-56 interleukin 1 complex Mus musculus 120-124 11201166-10 2001 When hepatocytes were pretreated with dexamethasone (Dex) and IL-6, the activation of IRAK was augmented in response to IL-1, indicating that IL-1 signaling is also up-regulated. Dexamethasone 53-56 interleukin 1 complex Mus musculus 142-146 11201166-11 2001 In addition, IL-1 treatment ather combined administration of Dex and IL-6 into mice markedly increased the serum level of serum amyloid A. Dexamethasone 61-64 interleukin 1 complex Mus musculus 13-17 7566437-10 1995 In mice treated with 100 micrograms DEX/mouse, the facilitatory effect of the lower DEX does in IL-1-induced PGE2 production was abolished. Dexamethasone 36-39 interleukin 1 complex Mus musculus 96-100 10201956-5 1999 125I-labeled IL-1 binding experiment showed that the level of binding was also up-regulated by the treatment with Dex and IL-6. Dexamethasone 114-117 interleukin 1 complex Mus musculus 13-17 10201956-8 1999 When hepatocytes were pretreated with Dex and IL-6, the activation of IL-1R-associated kinase was augmented in response to IL-1, indicating that IL-1 signaling was also augmented. Dexamethasone 38-41 interleukin 1 complex Mus musculus 70-74 10201956-8 1999 When hepatocytes were pretreated with Dex and IL-6, the activation of IL-1R-associated kinase was augmented in response to IL-1, indicating that IL-1 signaling was also augmented. Dexamethasone 38-41 interleukin 1 complex Mus musculus 123-127 10201956-9 1999 In addition, IL-1 treatment following administration of the combination of Dex and IL-6 into mice markedly increased the serum level of serum amyloid A. Dexamethasone 75-78 interleukin 1 complex Mus musculus 13-17 8898726-11 1996 Therefore, DEX blocks the induction of LIF mRNA by inhibiting both the production of IL-1 and its action on LIF gene expression. Dexamethasone 11-14 interleukin 1 complex Mus musculus 85-89 7566437-10 1995 In mice treated with 100 micrograms DEX/mouse, the facilitatory effect of the lower DEX does in IL-1-induced PGE2 production was abolished. Dexamethasone 84-87 interleukin 1 complex Mus musculus 96-100 7583520-7 1995 DEX and IX 207-887 dose-dependently decreased the immunoassayable IL-1 alpha level and the IL-1 like bioactivity as well. Dexamethasone 0-3 interleukin 1 complex Mus musculus 66-70 8079830-7 1994 Orally administered dexamethasone induced a dose-dependent reduction in IL-1 alpha, whereas indomethacin and IX 207-887, an IL-1-release inhibitor, failed to reduce the IL-1 alpha content in this model. Dexamethasone 20-33 interleukin 1 complex Mus musculus 72-76 7831195-6 1994 In keeping with these observations, the inhibitory action exerted by dexamethasone, in both IL-1- and IL-8-induced cell infiltration, was abrogated by passive immunisation of mice with specific anti-lipocortin 1 antibodies. Dexamethasone 69-82 interleukin 1 complex Mus musculus 92-106 7927490-5 1994 Both DEX and CPZ inhibited TNF production, whereas induction of IL-1 and IL-6 was inhibited by DEX but not by CPZ. Dexamethasone 95-98 interleukin 1 complex Mus musculus 64-68 8283056-5 1994 However, GM-CSF increased IL-1 binding to BMC both in vivo and in vitro after 8 h. Further studies showed that in vitro GM-CSF and dexamethasone synergistically increased IL-1 binding to BMC in a time- and dose-dependent manner. Dexamethasone 131-144 interleukin 1 complex Mus musculus 26-30 8283056-5 1994 However, GM-CSF increased IL-1 binding to BMC both in vivo and in vitro after 8 h. Further studies showed that in vitro GM-CSF and dexamethasone synergistically increased IL-1 binding to BMC in a time- and dose-dependent manner. Dexamethasone 131-144 interleukin 1 complex Mus musculus 171-175 2180256-5 1990 Furthermore, pretreatment of the M phi with dexamethasone, in order to reduce the release of IL1 and TNF, hardly reduces the effect on granulocyte activation. Dexamethasone 44-57 interleukin 1 complex Mus musculus 93-96 8115027-7 1993 In the anterior pituitary, a significant increase in the density of basal IL-1 receptors was observed 6 h following immobilization stress or after 7 days of DEX treatment while short-term DEX treatments are ineffective. Dexamethasone 157-160 interleukin 1 complex Mus musculus 74-78 8115027-7 1993 In the anterior pituitary, a significant increase in the density of basal IL-1 receptors was observed 6 h following immobilization stress or after 7 days of DEX treatment while short-term DEX treatments are ineffective. Dexamethasone 188-191 interleukin 1 complex Mus musculus 74-78 8482848-7 1993 Northern blot analysis revealed that IL-1 and TNF-alpha stimulated MCP-1 mRNA expression in a dose-dependent manner, whereas dexamethasone blocked MCP-1 expression by cells stimulated with IL-1. Dexamethasone 125-138 interleukin 1 complex Mus musculus 189-193 8423349-0 1993 Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. Dexamethasone 51-64 interleukin 1 complex Mus musculus 14-18 8423349-6 1993 The glucocorticoid dexamethasone (0.015 to 1.5 mg/kg) potently inhibited the elicitation of neutrophils induced by IL-1 when given systemically 2 h before the cytokine. Dexamethasone 19-32 interleukin 1 complex Mus musculus 115-119 1830617-4 1991 Dexamethasone strongly inhibited the PGE2 and IL-1 production by Y4 LPS-stimulated BALB/c mouse calvaria, as well as Y4 LPS-induced bone resorption. Dexamethasone 0-13 interleukin 1 complex Mus musculus 46-50 1830617-5 1991 Dexamethasone inhibited expression of membrane IL-1 on osteoblastic cells stimulated with Y4 LPS, but indomethacin did not. Dexamethasone 0-13 interleukin 1 complex Mus musculus 47-51 2142376-8 1990 Preincubation of cells with IL-1, retinoic acid, transforming growth factor beta (TGF-beta), or phorbol ester caused a reduction in apparent receptor numbers per cell, while preincubation with epidermal growth factor (EGF), dexamethasone, or parathyroid hormone (PTH) increased receptor numbers per cell. Dexamethasone 224-237 interleukin 1 complex Mus musculus 28-32 2788206-4 1989 This factor was inhibited by anti-IL-1 antiserum, and its synthesis, like that of IL-1, was inhibited by dexamethasone (DEX). Dexamethasone 105-118 interleukin 1 complex Mus musculus 82-86 2692568-2 1989 We have tested the effect of dexamethasone (DEX) and chlorpromazine (CPZ) on the lethal effect of IL-1, TNF and endotoxin. Dexamethasone 29-42 interleukin 1 complex Mus musculus 98-121 2692568-2 1989 We have tested the effect of dexamethasone (DEX) and chlorpromazine (CPZ) on the lethal effect of IL-1, TNF and endotoxin. Dexamethasone 44-47 interleukin 1 complex Mus musculus 98-121 2681261-6 1989 Finally, treatment of adrenalectomized mice with corticosterone or dexamethasone could inhibit the induction of serum IL-1 and TNF and modified the pattern of these cytokine-induced deaths. Dexamethasone 67-80 interleukin 1 complex Mus musculus 118-122 2788206-0 1989 Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron. Dexamethasone 0-13 interleukin 1 complex Mus musculus 85-98 2801312-5 1989 Dexamethasone reduced mIL-1 activity induced in vivo by C. parvum and also that induced by adherence in vitro. Dexamethasone 0-13 interleukin 1 complex Mus musculus 22-27 2788206-4 1989 This factor was inhibited by anti-IL-1 antiserum, and its synthesis, like that of IL-1, was inhibited by dexamethasone (DEX). Dexamethasone 120-123 interleukin 1 complex Mus musculus 34-38 2788206-4 1989 This factor was inhibited by anti-IL-1 antiserum, and its synthesis, like that of IL-1, was inhibited by dexamethasone (DEX). Dexamethasone 120-123 interleukin 1 complex Mus musculus 82-86 2788206-5 1989 Pretreatment of mice with DEX protected against the depression of liver cytochrome P-450 by LPS or TNF but not by IL-1, suggesting that IL-1 directly depresses cytochrome P-450 and that DEX acts by inhibiting IL-1 synthesis in vivo induced by LPS or TNF. Dexamethasone 26-29 interleukin 1 complex Mus musculus 136-140 2788206-5 1989 Pretreatment of mice with DEX protected against the depression of liver cytochrome P-450 by LPS or TNF but not by IL-1, suggesting that IL-1 directly depresses cytochrome P-450 and that DEX acts by inhibiting IL-1 synthesis in vivo induced by LPS or TNF. Dexamethasone 26-29 interleukin 1 complex Mus musculus 136-140 2784766-8 1989 In contrast with the transient increase in TNF, serum IL 1 was maximal 4 h post LPS injection and remained elevated at 24 h. In vitro studies with primary cultures of human peripheral blood monocytes and human umbilical cord vein endothelial cells demonstrated that LPS-induced monocyte IL 1 levels were reduced approximately 5-fold by 10(-7) M dexamethasone while dexamethasone had only minimal effects on endothelial cell IL 1. Dexamethasone 345-358 interleukin 1 complex Mus musculus 54-58 2784766-8 1989 In contrast with the transient increase in TNF, serum IL 1 was maximal 4 h post LPS injection and remained elevated at 24 h. In vitro studies with primary cultures of human peripheral blood monocytes and human umbilical cord vein endothelial cells demonstrated that LPS-induced monocyte IL 1 levels were reduced approximately 5-fold by 10(-7) M dexamethasone while dexamethasone had only minimal effects on endothelial cell IL 1. Dexamethasone 365-378 interleukin 1 complex Mus musculus 54-58 3259257-3 1988 The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg). Dexamethasone 84-97 interleukin 1 complex Mus musculus 36-40 3500955-4 1987 This IL-1-mediated antagonism of dexamethasone activity is not due to a down-regulation of glucocorticoid receptors in the cell line used, because the number of receptors and their affinity for dexamethasone is unchanged in IL-1-treated cells. Dexamethasone 194-207 interleukin 1 complex Mus musculus 5-9 3871468-6 1985 1) The reduced activity was not due to the presence of proliferation inhibitors since mixing the serum from dexamethasone-treated mice with purified IL-1 or adding the equivalent amount of steroid directly to thymocyte cultures did not reduce the degree of proliferation. Dexamethasone 121-134 interleukin 1 complex Mus musculus 162-166 33966129-9 2021 Adding the corticosteroid dexamethasone significantly reduced the response to IL1-ss stimulation. Dexamethasone 26-39 interleukin 1 complex Mus musculus 78-81 3261378-0 1988 Dexamethasone modulation of LPS, IL-1, and TNF stimulated serum amyloid A synthesis in mice. Dexamethasone 0-13 interleukin 1 complex Mus musculus 33-37 3261378-4 1988 Dexamethasone (DEX), a potent inhibitor of macrophage IL-1, TNF and IL-6 synthesis, was utilized to analyze the endogenous mediators of SAA synthesis in mice injected with lipopolysaccharide (LPS). Dexamethasone 0-13 interleukin 1 complex Mus musculus 54-58 3261378-4 1988 Dexamethasone (DEX), a potent inhibitor of macrophage IL-1, TNF and IL-6 synthesis, was utilized to analyze the endogenous mediators of SAA synthesis in mice injected with lipopolysaccharide (LPS). Dexamethasone 15-18 interleukin 1 complex Mus musculus 54-58 3500955-2 1987 This report examines the effects of IL-1 on the induction by dexamethasone of alkaline phosphatase in LEII murine endothelial cells. Dexamethasone 61-74 interleukin 1 complex Mus musculus 36-40 3500955-4 1987 This IL-1-mediated antagonism of dexamethasone activity is not due to a down-regulation of glucocorticoid receptors in the cell line used, because the number of receptors and their affinity for dexamethasone is unchanged in IL-1-treated cells. Dexamethasone 33-46 interleukin 1 complex Mus musculus 5-9