PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30719927-0 2019 Heptachlor-induced epithelial to mesenchymal transition in HK-2 cells mediated via TGF-beta1/Smad signalling. Heptachlor 0-10 transforming growth factor beta 1 Homo sapiens 83-92 30719927-1 2019 This study investigated the effect of heptachlor-induced oxidative stress (OS) on transforming growth factor (TGF)-beta1-mediated epithelial to mesenchymal transition (EMT) in human renal proximal tubular epithelial (HK-2) cells. Heptachlor 38-48 transforming growth factor beta 1 Homo sapiens 82-120 30719927-4 2019 In this study, we have shown that heptachlor-induced OS regulates the mRNA expression of TGF-beta1-mediated Smad signalling genes accompanied by increased nuclear localization of phosphorylated Smad-2 and phosphorylated Smad-3. Heptachlor 34-44 transforming growth factor beta 1 Homo sapiens 89-98 30719927-6 2019 In conclusion, heptachlor-induced OS might be responsible for the activation of TGF-beta1/Smad signalling which ultimately leads to renal damage by means of EMT. Heptachlor 15-25 transforming growth factor beta 1 Homo sapiens 80-89