PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10561081-0 2000 Modulation of CPP32 activity and induction of apoptosis in Human CEM X 174 lymphocytes by heptachlor, a chlorinated hydrocarbon insecticide. Heptachlor 90-100 caspase 3 Homo sapiens 14-19 10561081-4 2000 In this article, we describe the effect of heptachlor on the activity of the apoptosis protease CPP32. Heptachlor 43-53 caspase 3 Homo sapiens 96-101 10561081-5 2000 We show that heptachlor by itself was able to stimulate CPP32 activity at relatively high concentrations. Heptachlor 13-23 caspase 3 Homo sapiens 56-61 10561081-7 2000 Low concentrations of heptachlor (5 microM-10 microM) suppressed doxorubicin-induced CPP32 activity, and high concentrations of heptachlor (80 microM-120 microM) augmented it. Heptachlor 22-32 caspase 3 Homo sapiens 85-90