PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25466967-4	2015	Affinity of TC to the uptake transporters OATP1A2, -1B1, -1B3, -2B1, OCT1, -2, -3, OCTN2, NTCP, and ASBT and the efflux carriers P-gp, MRP2 and MRP3 transfected in HEK293 and MDCK2 cells was measured.	trospium chloride	12-14	solute carrier organic anion transporter family member 1A2	Homo sapiens	42-49	
25466967-6	2015	TC was shown to be a substrate of OATP1A2 (Km = 6.9 +- 1.3 mumol/L; Vmax = 41.6 +- 1.8 pmol/mg min), OCT1 (Km = 106 +- 16 mumol/L; Vmax = 269 +- 18 pmol/mg min), and P-gp (Km = 34.9 +- 7.5 mumol/L; Vmax = 105 +- 9.1 pmol/mg min, lipovesicle assay).	trospium chloride	0-2	solute carrier organic anion transporter family member 1A2	Homo sapiens	34-41	
25466967-7	2015	The genetic OATP1A2 variants *2 and *3 were loss-of-function transporters for TC.	trospium chloride	78-80	solute carrier organic anion transporter family member 1A2	Homo sapiens	12-19	
25466967-11	2015	TC was taken up into HBU cells (Km = 18.5 +- 4.8 mumol/L; Vmax = 106 +- 11.3 pmol/mg min) by mechanisms that could be synergistically inhibited by naringin (IC50 = 10.8 (8.4; 13.8) mumol/L) and verapamil (IC50 = 4.6 (2.8; 7.5) mumol/L), inhibitors of OATP1A2 and OCT1, respectively.	trospium chloride	0-2	solute carrier organic anion transporter family member 1A2	Homo sapiens	251-258