PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22120415-3 2013 METHODS: Trospium chloride at 1 mg/kg was intravenously administered to adult, middle-aged, and aged mice at 6, 12, and 24 months of age, respectively, and the absolute drug concentrations in the brain were analysed after 2 h. Furthermore, mRNA expression levels of relevant markers of blood-brain barrier integrity (occludin, claudin-5, and the drug efflux carrier P-glycoprotein) were analysed in brain samples from adult and aged mice. trospium chloride 9-26 claudin 5 Mus musculus 327-336