PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28087840-3	2017	In this study, we demonstrate cytotoxicity of Cholix on human hepatocytes in the presence of tumor necrosis factor alpha (TNF-alpha), which has been reported to play a fatal role in PEA administered to mice.	cholix	46-52	tumor necrosis factor	Homo sapiens	93-120	
33374361-9	2020	Cholix-induced apoptosis was regulated by mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) signaling pathways, which dramatically enhanced tumor necrosis factor-alpha (TNF-alpha) production in human liver, as well as the amount of epithelial-like HepG2 cancer cells.	cholix	0-6	tumor necrosis factor	Homo sapiens	157-184	
33374361-9	2020	Cholix-induced apoptosis was regulated by mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) signaling pathways, which dramatically enhanced tumor necrosis factor-alpha (TNF-alpha) production in human liver, as well as the amount of epithelial-like HepG2 cancer cells.	cholix	0-6	tumor necrosis factor	Homo sapiens	186-195	
28087840-9	2017	Reactive oxygen species (ROS) inhibitor, N-acetyl cysteine (NAC), suppressed TNF-alpha/Cholix-induced JNK and ERK phosphorylation, resulting in inhibition of PARP cleavage.	cholix	87-93	tumor necrosis factor	Homo sapiens	77-86	
28087840-10	2017	These data suggest that ROS and JNK pathways are important mediators of TNF-alpha/Cholix-induced HepG2 cell death.	cholix	82-88	tumor necrosis factor	Homo sapiens	72-81	
28087840-3	2017	In this study, we demonstrate cytotoxicity of Cholix on human hepatocytes in the presence of tumor necrosis factor alpha (TNF-alpha), which has been reported to play a fatal role in PEA administered to mice.	cholix	46-52	tumor necrosis factor	Homo sapiens	122-131	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	42-48	tumor necrosis factor	Homo sapiens	74-83	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	42-48	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	42-48	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	42-48	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-4	2017	Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not.	cholix	88-94	tumor necrosis factor	Homo sapiens	96-105	
28087840-5	2017	In the early stage of cell death, Cholix increased phosphorylation of mitogen-activated protein kinases (e.g., p38, ERK, JNK) and Akt, which was not affected by TNF-alpha alone.	cholix	34-40	tumor necrosis factor	Homo sapiens	161-170