PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9309381-2	1997	IL6 is another cytokine important in the mechanisms of bone resorption and could be a target for the actions of SK&F 86002.	amicloral	112-118	interleukin 6	Homo sapiens	0-3	
9309381-4	1997	Both indomethacin (5 x 10(-8)-5 x 10(-6) M) and SK&F 86002 (5 x 10(-7)-10(-5) M) markedly inhibited the IL6 release and totally inhibited resorption at all concentrations tested.	amicloral	48-54	interleukin 6	Homo sapiens	108-111	
9309381-6	1997	In human osteoblastic cells (SaOS2) both basal and TNF alpha-stimulated IL6 production were inhibited in a concentration-related manner by SK&F 86002 but not by indomethacin.	amicloral	139-145	interleukin 6	Homo sapiens	72-75	
9309381-7	1997	The effect of SK&F 86002 was greatest in 6 h cultures where relatively low levels of IL6 are produced and progressively less in 24 and 48 h cultures which produce higher levels of IL6.	amicloral	14-20	interleukin 6	Homo sapiens	89-92	
9309381-7	1997	The effect of SK&F 86002 was greatest in 6 h cultures where relatively low levels of IL6 are produced and progressively less in 24 and 48 h cultures which produce higher levels of IL6.	amicloral	14-20	interleukin 6	Homo sapiens	184-187	
9309381-9	1997	Therefore, SK&F 86002 may inhibit IL6 production in osteoblastic cells via a more direct mechanism, possibly involving inhibition of the p38 MAP kinase, the mechanism proposed for its inhibition of IL 1 beta and TNF alpha release.	amicloral	11-17	interleukin 6	Homo sapiens	38-41