PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22156377-8 2011 Based on these results, THC may regulate the aging process via an evolutionarily conserved signaling pathway that includes both foxo and Sir2. tetrahydrocurcumin 24-27 Sirtuin 1 Drosophila melanogaster 137-141 23325575-8 2013 In addition, THC extended lifespan in Drosophila and inhibited the oxidative stress response by regulating FOXO and Sir2. tetrahydrocurcumin 13-16 Sirtuin 1 Drosophila melanogaster 116-120